[Term]
id: PR:000062000
name: receptor-type tyrosine-protein kinase FLT3 sequence variant D835H, signal peptide removed phosphorylated 1 (human)
def: "A receptor-type tyrosine-protein kinase FLT3 (human) that has a His residue at the position equivalent to Asp-835 of the amino acid sequence represented by UniProtKB:P36888-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-589, Tyr-591, Tyr-599, Tyr-768, Tyr-955, and Tyr-969. Example: UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Asp-835, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9682372]
comment: Category=organism-modification.
synonym: "hFLT3/var:D835H/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-6Y FLT3 D835H" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9682372]
synonym: "UniProtKB:P36888, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Asp-835, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Asp-835, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9682372 "PR:000062000 located_in GO:0005886"
is_a: PR:P36888 ! receptor-type tyrosine-protein kinase FLT3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens