[Term]
id: PR:000062809
name: RAF proto-oncogene serine/threonine-protein kinase sequence variant T491R phosphorylated 1 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9656017]
comment: Category=organism-modification.
synonym: "hRAF1/var:T491R/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-S338,Y341,S494,S621 RAF1 T491R" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9656017]
synonym: "UniProtKB:P04049, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P04049-1, Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9656017 "PR:000062809 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens