[Term]
id: PR:000062848
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, initiator methionine removed phosphorylated 2 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Ser-370, Ser-380, Thr-382, Thr-383, and Ser-385 of the amino acid sequence represented by UniProtKB:P60484-1. Example: UniProtKB:P60484-1, 2-403, Ser-370/Ser-380/Ser-385, MOD:00046|Thr-382/Thr-383, MOD:00047." [PRO:DNx, Reactome:R-HSA-8850936]
comment: Category=organism-modification.
synonym: "hPTEN/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p-3S,2T-PTEN" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-8850936]
synonym: "UniProtKB:P60484, 2-403, Ser-370/Ser-380/Ser-385, MOD:00046|Thr-382/Thr-383, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P60484-1, 2-403, Ser-370/Ser-380/Ser-385, MOD:00046|Thr-382/Thr-383, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8850936 "PR:000062848 located_in GO:0005829"
is_a: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens