[Term]
id: PR:000063115
name: coagulation factor VIII, signal peptide removed sulfated 1 (human)
def: "A coagulation factor VIII (human) that has had the signal peptide removed and that has been sulfated on the residues at the positions equivalent to Tyr-365, Tyr-737, Tyr-738, Tyr-742, Tyr-1683, and Tyr-1699 of the amino acid sequence represented by UniProtKB:P00451-1. Example: UniProtKB:P00451-1, 20-2351, Tyr-365/Tyr-737/Tyr-738/Tyr-742/Tyr-1683/Tyr-1699, MOD:00181." [PRO:DNx, Reactome:R-HSA-9668036]
comment: Category=organism-modification.
synonym: "hF8/SigPep-/Sulf:1" EXACT PRO-short-label [PRO:DNx]
synonym: "OSulf-6Y-FVIII precursor" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9668036]
synonym: "UniProtKB:P00451, 20-2351, Tyr-365/Tyr-737/Tyr-738/Tyr-742/Tyr-1683/Tyr-1699, MOD:00181" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P00451-1, 20-2351, Tyr-365/Tyr-737/Tyr-738/Tyr-742/Tyr-1683/Tyr-1699, MOD:00181" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9668036 "PR:000063115 located_in GO:0005796"
is_a: PR:P00451 ! coagulation factor VIII (human)
relationship: has_part MOD:00181 ! O4'-sulfo-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens