[Term]
id: PR:000063224
name: receptor-type tyrosine-protein kinase FLT3 sequence variant K663R, signal peptide removed phosphorylated 1 (human)
def: "A receptor-type tyrosine-protein kinase FLT3 (human) that has an Arg residue at the position equivalent to Lys-663 of the amino acid sequence represented by UniProtKB:P36888-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-589, Tyr-591, Tyr-599, Tyr-768, Tyr-955, and Tyr-969. Example: UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Lys-663, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9691940]
comment: Category=organism-modification.
synonym: "hFLT3/var:K663R/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-6Y FLT3 K633R" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9691940]
synonym: "UniProtKB:P36888, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Lys-663, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|Lys-663, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9691940 "PR:000063224 located_in GO:0005886"
is_a: PR:P36888 ! receptor-type tyrosine-protein kinase FLT3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens