[Term]
id: PR:000063974
name: RAF proto-oncogene serine/threonine-protein kinase sequence variant T491I phosphorylated 2 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Ile residue at the position equivalent to Thr-491 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residue at the position equivalent to Ser-621. Example: UniProtKB:P04049-1, Thr-491, CHEBI:30009|Ser-621, MOD:00046." [PRO:DNx, Reactome:R-HSA-9656143]
comment: Category=organism-modification.
synonym: "hRAF1/var:T491I/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p-S621-RAF1 T491I" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9656143]
synonym: "UniProtKB:P04049, Thr-491, CHEBI:30009|Ser-621, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P04049-1, Thr-491, CHEBI:30009|Ser-621, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9656143 "PR:000063974 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens