[Term]
id: PR:000064065
name: RAF proto-oncogene serine/threonine-protein kinase sequence variant T260R phosphorylated 2 (human)
def: "A RAF proto-oncogene serine/threonine-protein kinase (human) that has an Arg residue at the position equivalent to Thr-260 of the amino acid sequence represented by UniProtKB:P04049-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-338, Tyr-341, Thr-491, Ser-494, and Ser-621. Example: UniProtKB:P04049-1, Thr-260, CHEBI:29952|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047." [PRO:DNx, Reactome:R-HSA-9656077]
comment: Category=organism-modification.
synonym: "hRAF1/var:T260R/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p-S338,Y341,T492,S494,S621 RAF1 T260R" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9656077]
synonym: "UniProtKB:P04049, Thr-260, CHEBI:29952|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P04049-1, Thr-260, CHEBI:29952|Ser-338/Ser-494/Ser-621, MOD:00046|Tyr-341, MOD:00048|Thr-491, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9656077 "PR:000064065 located_in GO:0005829"
is_a: PR:P04049 ! RAF proto-oncogene serine/threonine-protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens