[Term]
id: PR:000064163
name: serine/threonine-protein kinase B-raf sequence variant E586K, initiator methionine removed phosphorylated 2 (human)
def: "A serine/threonine-protein kinase B-raf (human) that has a Lys residue at the position equivalent to Glu-586 of the amino acid sequence represented by UniProtKB:P15056, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-446, Thr-599, Ser-602, and Ser-729. UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Glu-586, CHEBI:29967|Thr-599, MOD:00047." [PRO:DNx, Reactome:R-HSA-8936639]
comment: Category=organism-modification.
synonym: "hBRAF/var:E586K/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "p-BRAF E586K" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-8936639]
synonym: "UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Glu-586, CHEBI:29967|Thr-599, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8936639 "PR:000064163 located_in GO:0005886"
is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens