[Term]
id: PR:000064543
name: interferon-induced, double-stranded RNA-activated protein kinase, initiator methionine removed phosphorylated 1 (human)
def: "An interferon-induced, double-stranded RNA-activated protein kinase (human) that has had the initiator methionine removed and that has been phosphorylated on the residues at the positions equivalent to Thr-88, Thr-89, Thr-90, Tyr-101, Tyr-162, Ser-242, Thr-255, Thr-258, Tyr-293, Thr-446, and Thr-451 of the amino acid sequence represented by UniProtKB:P19525-1. Example: UniProtKB:P19525-1, 2-551, Thr-88/Thr-89/Thr-90/Thr-255/Thr-258/Thr-446/Thr-451, MOD:00047|Tyr-101/Tyr-162/Tyr-293, MOD:00048|Ser-242, MOD:00046." [PRO:DNx, Reactome:R-HSA-9833834, Reactome:R-HSA-9836332]
comment: Category=organism-modification.
synonym: "hEIF2AK2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-EIF2AK2" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9833834, Reactome:R-HSA-9836332]
synonym: "UniProtKB:P19525, 2-551, Thr-88/Thr-89/Thr-90/Thr-255/Thr-258/Thr-446/Thr-451, MOD:00047|Tyr-101/Tyr-162/Tyr-293, MOD:00048|Ser-242, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P19525-1, 2-551, Thr-88/Thr-89/Thr-90/Thr-255/Thr-258/Thr-446/Thr-451, MOD:00047|Tyr-101/Tyr-162/Tyr-293, MOD:00048|Ser-242, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9833834 "PR:000064543 located_in GO:0005829"
xref: Reactome:R-HSA-9836332 "PR:000064543 located_in GO:0005654"
is_a: PR:P19525 ! interferon-induced, double-stranded RNA-activated protein kinase (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens