[Term]
id: PR:000064637
name: histone H2AX, initiator methionine removed phosphorylated and ubiquitinated 1 (human)
def: "A histone H2AX (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-140 and ubiquitinated on the residues at the positions equivalent to Lys-14 and Lys-16 of the amino acid sequence represented by UniProtKB:P16104. UniProtKB:P16104, 2-143, Lys-14/Lys-16, MOD:01148|Ser-140, MOD:00046." [PRO:DNx, Reactome:R-HSA-5682847]
comment: Category=organism-modification.
synonym: "hH2AFX/InitMet-/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "K63PolyUb-K14,K16,p-S140-H2AFX" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-5682847]
synonym: "UniProtKB:P16104, 2-143, Lys-14/Lys-16, MOD:01148|Ser-140, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5682847 "PR:000064637 located_in GO:0005654"
is_a: PR:P16104 ! histone H2AX (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens