[Term]
id: PR:000064744
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, initiator methionine removed ubiquitinated 1 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human) that has had the initiator methionine removed and that has been ubiquitinated on the residue at the position equivalent to Lys-289 of the amino acid sequence represented by UniProtKB:P60484-1. Example: UniProtKB:P60484-1, 2-403, Lys-289, MOD:01148." [PRO:DNx, Reactome:R-HSA-8948777]
comment: Category=organism-modification.
synonym: "hPTEN/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "K48polyUb-K289-PTEN" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-8948777]
synonym: "UniProtKB:P60484, 2-403, Lys-289, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P60484-1, 2-403, Lys-289, MOD:01148" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-8948777 "PR:000064744 located_in GO:0005829"
is_a: PR:P60484 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens