[Term]
id: PR:000064768
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated and ubiquitinated 1 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-166 and Ser-188 of the amino acid sequence represented by UniProtKB:Q00987-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:Q00987-1, Ser-166/Ser-188, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-6795669]
comment: Category=organism-modification.
synonym: "hMDM2/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PolyUb,p-S166,S188-MDM2" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-6795669]
synonym: "UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q00987-1, Ser-166/Ser-188, MOD:00046|MOD:01148" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6795669 "PR:000064768 located_in GO:0005654"
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens