[Term]
id: PR:000064772
name: interleukin-1 receptor-associated kinase 1 phosphorylated and ubiquitinated 1 (human)
def: "An interleukin-1 receptor-associated kinase 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-209, Ser-376 and Thr-387, and ubiquitinated on the residues at the positions equivalent to Lys-134 and Lys-180 of the amino acid sequence represented by UniProtKB:P51617-1 and that includes at least 1 additional phosphorylated threonine and at least 2 additional phosphorylated serines. Example: UniProtKB:P51617-1, Lys-134/Lys-180, MOD:01148|Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047." [PRO:DNx, Reactome:R-HSA-975112]
comment: Category=organism-modification.
synonym: "hIRAK1/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "K63polyUb-hp-IRAK1" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-975112]
synonym: "UniProtKB:P51617, Lys-134/Lys-180, MOD:01148|Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P51617-1, Lys-134/Lys-180, MOD:01148|Thr-209/Thr-387, MOD:00047|Ser-376, MOD:00046|MOD:00046(2+)|MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-975112 "PR:000064772 located_in GO:0010008"
is_a: PR:P51617 ! interleukin-1 receptor-associated kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens