[Term]
id: PR:000064784
name: mediator of DNA damage checkpoint protein 1 phosphorylated, sumoylated, and ubiquitinated 1 (human)
def: "A mediator of DNA damage checkpoint protein 1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-4, Thr-699, Thr-719, Thr-752 and Thr-765, and sumoylated on the residue at the position equivalent to Lys-1840 of the amino acid sequence represented by UniProtKB:Q14676-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:Q14676-1, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047|Lys-1840, MOD:01149|MOD:01148." [PRO:DNx, Reactome:R-HSA-5684074]
comment: Category=organism-modification.
synonym: "hMDC1/PhosSumoUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "K48PolyUb,SUMO2-K1840,p-5T-MDC1" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-5684074]
synonym: "UniProtKB:Q14676, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047|Lys-1840, MOD:01149|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q14676-1, Thr-4/Thr-699/Thr-719/Thr-752/Thr-765, MOD:00047|Lys-1840, MOD:01149|MOD:01148" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5684074 "PR:000064784 located_in GO:0005654"
is_a: PR:Q14676 ! mediator of DNA damage checkpoint protein 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens