[Term]
id: PR:000064797
name: receptor-type tyrosine-protein kinase FLT3, signal peptide removed phosphorylated and ubiquitinated 1 (human)
def: "A receptor-type tyrosine-protein kinase FLT3 (human) that has had the signal peptide removed, that has been phosphorylated on the residues at the positions equivalent to Tyr-589, Tyr-591, Tyr-599, Tyr-768, Tyr-955, and Tyr-969 of the amino acid sequence represented by UniProtKB:P36888-1, and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|MOD:01148." [PRO:DNx, Reactome:R-HSA-9706171, Reactome:R-HSA-9706174]
comment: Category=organism-modification.
synonym: "hFLT3/SigPep-/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Ub-pY FLT3" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9706171, Reactome:R-HSA-9706174]
synonym: "UniProtKB:P36888, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P36888-1, 27-993, Tyr-589/Tyr-591/Tyr-599/Tyr-768/Tyr-955/Tyr-969, MOD:00048|MOD:01148" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9706171 "PR:000064797 located_in GO:0005886"
xref: Reactome:R-HSA-9706174 "PR:000064797 located_in GO:0010008"
is_a: PR:P36888 ! receptor-type tyrosine-protein kinase FLT3 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens