[Term]
id: PR:000064846
name: mixed lineage kinase domain-like protein phosphorylated and ubiquitinated 1 (human)
def: "A mixed lineage kinase domain-like protein (human) that has been phosphorylated on the residues at the positions equivalent to Thr-357 and Ser-358 and ubiquitinated on the residue at the position equivalent to Lys-50 of the amino acid sequence represented by UniProtKB:Q8NB16-1. Example: UniProtKB:Q8NB16-1, Lys-50, MOD:01148|Thr-357, MOD:00047|Ser-358, MOD:00046." [PRO:DNx, Reactome:R-HSA-9793468]
comment: Category=organism-modification.
synonym: "hMLKL/PhosUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "K63PolyUb-K50,p-T357,S358-MLKL" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9793468]
synonym: "UniProtKB:Q8NB16, Lys-50, MOD:01148|Thr-357, MOD:00047|Ser-358, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:Q8NB16-1, Lys-50, MOD:01148|Thr-357, MOD:00047|Ser-358, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9793468 "PR:000064846 located_in GO:0005829"
is_a: PR:Q8NB16 ! mixed lineage kinase domain-like protein (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens