[Term]
id: PR:000000628
name: TGF-beta 1 sequence variant R218H cleaved 2 (human)
def: "A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PRO:CNA, PRO:DAN, PMID:11278244]
comment: Category=organism-modification.
synonym: "hTGFB1/var:R218H/Clv:2" EXACT PRO-short-label [PRO:DAN]
synonym: "TGF-beta 1 sequence variant 4 cleaved 2 (human)" EXACT [PRO:DAN]
synonym: "UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN]
is_a: PR:000021907 ! TGF-beta 1 sequence variant R218H, signal peptide removed form (human)
relationship: output_of GO:0016485 ! protein processing
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens