[Term]
id: PR:000035428
name: mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
def: "A mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form in human that has had Thr-620 phosphorylated by CDK1, and Ser-676 and/or Thr-680 phosphorylated by PLK1. Additionally, Thr-792 and/or Thr-1008 may be phosphorylated based on in vitro experiments. Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PRO:KER, PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PMID:23079597]
comment: Category=organism-modification. Note: This phosphorylated form is observed during pro metaphase, spindle depolymerization (nocodazole), and lack of kinetochore tension (taxol). Kinase=("CDK1"; PR:000003271; Thr-620). Kinase=("PLK1"; PR:P53350; Ser-676/Thr-680).
synonym: "hBUB1B/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "BUBR1 phosphorylated (human)" RELATED []
synonym: "hBUBR1 phosphorylated" RELATED []
synonym: "UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000035427 ! mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens