[Term]
id: PR:000050167
name: secretory polymeric IgA1 immunoglobulin complex (human)
def: "A polymeric IgA1 immunoglobulin complex (human) that is complexed with one chain of secretory component (SC). Polymeric IgA1 is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [PRO:ADD, PMID:16362985, GOC:add, ISBN:0781765196]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.
synonym: "h(IgA1/secretory)polymeric" EXACT PRO-short-label [PRO:DAN]
synonym: "secretory IgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
synonym: "sIgA1 antibody (human)" EXACT [PRO:ADD, GOC:add]
synonym: "secretory IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "sIgA antibody (human)" BROAD [PRO:ADD, GOC:add]
intersection_of: PR:000050165 ! polymeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050163 {maxCardinality="4"} ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050163 {minCardinality="2"} ! monomeric IgA1 immunoglobulin complex (human)
intersection_of: has_component PR:000050169 ! polymeric immunoglobulin receptor secretory component (human)
intersection_of: has_component PR:P01591 {cardinality="1"} ! immunoglobulin J chain (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens