[Term]
id: PR:000060366
name: mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]
comment: Category=organism-modification.
synonym: "hMAPK1/var:D321V/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P28482, 2-360, Thr-185/Tyr-187, MOD:00048|Asp-321, CHEBI:30015" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Asp-321, CHEBI:30015" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "p-T185,Y187 MAPK1 D321V" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9652791]
xref: Reactome:R-HSA-9652791 "PR:000060366 located_in GO:0005829"
is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine