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Protein Ontology report - TGF-beta superfamily receptor type-2 with activin receptor domain
PR:000000007 - http://purl.obolibrary.org/obo/PR_000000007
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000007   
  PRO nameTGF-beta superfamily receptor type-2 with activin receptor domain 
  Definition"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an extracellular Activin types I and II receptor domain (Pfam:PF01064), a transmembrane domain, and a Protein kinase domain (Pfam:PF00069). The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type-1, and type-2 receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 11                                        
         Sequence7                                                  Organism-Sequence 29                                        
         Modification4                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000627
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
TGFBR2
Yes
gene


PR:000000037 BMP receptor type-2
BMPR2
Yes
organism-gene


PR:O35607 bone morphogenetic protein receptor type-2 (mouse)
mBMPR2

organism-sequence


PR:O35607-1 bone morphogenetic protein receptor type-2 isoform 1 (mouse)
mBMPR2/iso:1
Yes
organism-gene


PR:Q13873 bone morphogenetic protein receptor type-2 (human)
hBMPR2

organism-sequence


PR:000000149 BMP receptor type-2 sequence variant C60Y (human)
hBMPR2/var:C60Y
Yes
organism-sequence


PR:000000150 BMP receptor type-2 sequence variant D485G (human)
hBMPR2/var:D485G
Yes
organism-sequence


PR:000000151 BMP receptor type-2 sequence variant R491Q (human)
hBMPR2/var:R491Q
Yes
organism-sequence


PR:000000152 BMP receptor type-2 sequence variant R491W (human)
hBMPR2/var:R491W
Yes
organism-sequence


PR:000000153 BMP receptor type-2 sequence variant K512T (human)
hBMPR2/var:K512T
Yes
organism-sequence


PR:000000154 BMP receptor type-2 sequence variant N519K (human)
hBMPR2/var:N519K
Yes
organism-sequence


PR:000000155 BMP receptor type-2 sequence variant C117Y (human)
hBMPR2/var:C117Y
Yes
organism-sequence


PR:000000156 BMP receptor type-2 sequence variant C118W (human)
hBMPR2/var:C118W
Yes
organism-sequence


PR:000000157 BMP receptor type-2 sequence variant C123R (human)
hBMPR2/var:C123R
Yes
organism-sequence


PR:000000158 BMP receptor type-2 sequence variant C123S (human)
hBMPR2/var:C123S
Yes
organism-sequence


PR:000000159 BMP receptor type-2 sequence variant E224D (human)
hBMPR2/var:E224D
Yes
organism-sequence


PR:000000160 BMP receptor type-2 sequence variant C347Y (human)
hBMPR2/var:C347Y
Yes
organism-sequence


PR:000000161 BMP receptor type-2 sequence variant C420R (human)
hBMPR2/var:C420R
Yes
organism-sequence


PR:000000162 BMP receptor type-2 sequence variant C483R (human)
hBMPR2/var:C483R
Yes
organism-sequence


PR:Q13873-1 bone morphogenetic protein receptor type-2 isoform 1 (human)
hBMPR2/iso:1
Yes
organism-sequence


PR:Q13873-2 bone morphogenetic protein receptor type-2 isoform h2 (human)
hBMPR2/iso:h2

organism-modification


PR:000046497 bone morphogenetic protein receptor type-2, signal peptide removed form (human)
hBMPR2/SigPep-

organism-modification


PR:000057061 bone morphogenetic protein receptor type-2 N-glycosylated 1 (human)
hBMPR2/NGlyco:1

organism-modification


PR:000057062 bone morphogenetic protein receptor type-2 O-glycosylated 1 (human)
hBMPR2/OGlyco:1

organism-modification


PR:000065377 bone morphogenetic protein receptor type-2 methylated 1 (human)
hBMPR2/Me:1

organism-modification


PR:000065967 bone morphogenetic protein receptor type-2 deaminated 1 (human)
hBMPR2/Deam:1

organism-modification


PR:000073289 bone morphogenetic protein receptor type-2 deaminated 2 (human)
hBMPR2/Deam:2

organism-modification


PR:000081621 bone morphogenetic protein receptor type-2 deaminated 3 (human)
hBMPR2/Deam:3

sequence


PR:000000148 BMP receptor type-2 isoform 1
BMPR2/iso:1

organism-sequence


PR:O35607-1 bone morphogenetic protein receptor type-2 isoform 1 (mouse)
mBMPR2/iso:1
Yes
organism-sequence


PR:Q13873-1 bone morphogenetic protein receptor type-2 isoform 1 (human)
hBMPR2/iso:1
Yes
gene


PR:000000070 activin receptor type-2A
ACVR2A
Yes
organism-gene


PR:P27037 activin receptor type-2A (human)
hACVR2A

organism-sequence


PR:P27037-1 activin receptor type-2A isoform 1 (human)
hACVR2A/iso:1

organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
organism-sequence


PR:P27037-2 activin receptor type-2A isoform h2 (human)
hACVR2A/iso:h2

organism-modification


PR:000046258 activin receptor type-2A, signal peptide removed form (human)
hACVR2A/SigPep-

organism-gene


PR:P27038 activin receptor type-2A (mouse)
mACVR2A

organism-sequence


PR:P27038-1 activin receptor type-2A isoform 1 (mouse)
mACVR2A/iso:1
Yes
organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
organism-gene


PR:P38444 activin receptor type-2A (rat)
rACVR2A

organism-gene


PR:Q90669 activin receptor type-2A (chicken)
chick-ACVR2A

sequence


PR:000000208 activin receptor type-2A isoform 1
ACVR2A/iso:1

organism-sequence


PR:P27037-1 activin receptor type-2A isoform 1 (human)
hACVR2A/iso:1

organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
organism-sequence


PR:P27038-1 activin receptor type-2A isoform 1 (mouse)
mACVR2A/iso:1
Yes
organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
modification


PR:000000414 activin receptor type-2A isoform 1 glycosylated and phosphorylated form
ACVR2A/iso:1/GlycoPhos+

modification


PR:000000528 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1
ACVR2A/iso:1/GlycoPhos:1

organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
gene


PR:000000071 activin receptor type-2B
ACVR2B
Yes
organism-gene


PR:P27040 activin receptor type-2B (mouse)
mACVR2B

organism-sequence


PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse)
mACVR2B/iso:ActR-IIB1
Yes
organism-sequence


PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse)
mACVR2B/iso:ActR-IIB2

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse)
mACVR2B/iso:ActR-IIB3
Yes
organism-sequence


PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse)
mACVR2B/iso:ActR-IIB4
Yes
organism-gene


PR:P38445 activin receptor type-2B (rat)
rACVR2B

organism-gene


PR:Q13705 activin receptor type-2B (human)
hACVR2B

organism-sequence


PR:000000214 activin receptor type-2B sequence variant R40H (human)
hACVR2B/var:R40H
Yes
organism-sequence


PR:000000215 activin receptor type-2B sequence variant V494I (human)
hACVR2B/var:V494I
Yes
organism-sequence


PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
Yes
organism-modification


PR:000046259 activin receptor type-2B, signal peptide removed form (human)
hACVR2B/SigPep-

organism-modification


PR:000076998 activin receptor type-2B phosphorylated 1 (human)
hACVR2B/Phos:1

organism-gene


PR:Q90670 activin receptor type-2B (chicken)
chick-ACVR2B

organism-sequence


PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken)
chick-ACVR2B/iso:ActR-IIB2

sequence


PR:000000209 activin receptor type-2B isoform ActR-IIB2
ACVR2B/iso:ActR-IIB2

organism-sequence


PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse)
mACVR2B/iso:ActR-IIB2

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human)
hACVR2B/iso:ActR-IIB2
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-sequence


PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken)
chick-ACVR2B/iso:ActR-IIB2

modification


PR:000000415 activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form
ACVR2B/iso:ActR-IIB2/GlycoPhos+

modification


PR:000000529 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
ACVR2B/iso:ActR-IIB2/NGlycoPhos:1

organism-modification


PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
organism-modification


PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
Yes
sequence


PR:000000210 activin receptor type-2B isoform ActR-IIBtrunc
ACVR2B/iso:ActR-IIBtrunc

organism-sequence


PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human)
hACVR2B/iso:ActR-IIB1
Yes
sequence


PR:000000211 activin receptor type-2B isoform ActR-IIB1
ACVR2B/iso:ActR-IIB1

organism-sequence


PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse)
mACVR2B/iso:ActR-IIB1
Yes
sequence


PR:000000212 activin receptor type-2B isoform ActR-IIB3
ACVR2B/iso:ActR-IIB3

organism-sequence


PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse)
mACVR2B/iso:ActR-IIB3
Yes
sequence


PR:000000213 activin receptor type-2B isoform ActR-IIB4
ACVR2B/iso:ActR-IIB4

organism-sequence


PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse)
mACVR2B/iso:ActR-IIB4
Yes
organism-gene


PR:A0A0G2KN81 serine/threonine-protein kinase receptor (zebrafish)
z-ACVR2B

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000007 TGFBR2
These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PIRSF:PIRSF000627
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PIRSF:PIRSF000627
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PIRSF:PIRSF000627
GO:0005515 protein binding PIRSF:PIRSF000627
PR:000000037 BMPR2
Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PIRSF:PIRSF500434
PR:000000070 ACVR2A acts_upstream_of_or_withinGO:0032924 activin receptor signaling pathway PIRSF:PIRSF500457
enablesGO:0048185 activin binding PIRSF:PIRSF500457
PR:000000071 ACVR2B acts_upstream_of_or_withinGO:0032924 activin receptor signaling pathway PIRSF:PIRSF500456
enablesGO:0048185 activin binding PIRSF:PIRSF500456
PR:000000149 hBMPR2/var:C60Y
Example: UniProtKB:Q13873-1, Cys-60, CHEBI:46858		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450
PR:000000150 hBMPR2/var:D485G
Example: UniProtKB:Q13873-1, Asp-485, CHEBI:29947		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000151 hBMPR2/var:R491Q
Example: UniProtKB:Q13873-1, Arg-491, CHEBI:30011		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10903931
PR:000000152 hBMPR2/var:R491W
Example: UniProtKB:Q13873-1, Arg-491, CHEBI:29954		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10903931
PR:000000153 hBMPR2/var:K512T
Example: UniProtKB:Q13873-1, Lys-512, CHEBI:30013		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000154 hBMPR2/var:N519K
Example: UniProtKB:Q13873-1, Asn-519, CHEBI:29967		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension UniProtKB_VAR:VAR_013683
PR:000000155 hBMPR2/var:C117Y
Example: UniProtKB:Q13873-1, Cys-117, CHEBI:46858		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450
PR:000000156 hBMPR2/var:C118W
Example: UniProtKB:Q13873-1, Cys-118, CHEBI:29954		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000157 hBMPR2/var:C123R
Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29952		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000158 hBMPR2/var:C123S
Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29999		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000159 hBMPR2/var:E224D
Example: UniProtKB:Q13873-1, Glu-224, CHEBI:29958		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000160 hBMPR2/var:C347Y
Example: UniProtKB:Q13873-1, Cys-347, CHEBI:46858		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000161 hBMPR2/var:C420R
Example: UniProtKB:Q13873-1, Cys-420, CHEBI:29952		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000162 hBMPR2/var:C483R
Example: UniProtKB:Q13873-1, Cys-483, CHEBI:29952		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450; PMID:12358323
PR:000000214 hACVR2B/var:R40H
Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000000215 hACVR2B/var:V494I
Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009		 associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000036440 mACVR2A/iso:1/GlycoPhos:1 acts_upstream_of_or_withinGO:0008584 male gonad development PMID:7885474
GO:0009952 anterior/posterior pattern specification PMID:10452853; PMID:16991118
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8395525
GO:0016362 activin receptor activity, type II PMID:8395525
GO:0019838 growth factor binding PMID:11459935; PMID:12414726
GO:0042803 protein homodimerization activity PMID:8612709
located_inGO:0048179 activin receptor complex PMID:8395525
PR:000036441 hACVR2A/iso:1/GlycoPhos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:1314589
enablesGO:0016362 activin receptor activity, type II PMID:12665502
located_inGO:0005886 plasma membrane PMID:1314589
GO:0048179 activin receptor complex PMID:8622651
PR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8721982
GO:0009952 anterior/posterior pattern specification PMID:10452853; PMID:16991118
GO:0032925 regulation of activin receptor signaling pathway PMID:8721982
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:1326537
GO:0019838 growth factor binding PMID:11459935; PMID:12414726
NOT GO:0050431 transforming growth factor beta binding PMID:1326537
PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8622651
GO:0005515 protein binding PMID:11279102; PMID:9872992
GO:0016362 activin receptor activity, type II PMID:8622651
located_inGO:0005886 plasma membrane PMID:8161782
GO:0048179 activin receptor complex PMID:8622651
PR:O35607-1 mBMPR2/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:12117821
located_inGO:0009986 cell surface PMID:12117821
PR:P27038-1 mACVR2A/iso:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8395525
PR:P27040-1 mACVR2B/iso:ActR-IIB1 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:Q13705-1 hACVR2B/iso:ActR-IIB2 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8161782
PR:Q13705-2 hACVR2B/iso:ActR-IIB1 enablesNOT GO:0016362 activin receptor activity, type II PMID:9916847
located_inSO:0001587 stop_gained PMID:9916847
PR:Q13873-1 hBMPR2/iso:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:7644468
enablesGO:0005515 protein binding with PR:P12643 BMP-2 (human) PMID:7791754
GO:0005515 protein binding with PR:P18075 BMP-7 (human) PMID:7791754
located_inGO:0005886 plasma membrane PMID:7791754
GO:0009986 cell surface PMID:10712517
GO:0043235 receptor complex PMID:7791754