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Protein Ontology report - cullin

PR:000000013 - http://purl.obolibrary.org/obo/PR_000000013

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000013

PRO name

cullin

Definition

"A protein that has a core domain composition consisting of a cullin domain that functions as a molecular scaffold responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases." [PIRSF:PIRSF017874]

PRO Category

family

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Family	1	Organism-Family	0
Gene	11	Organism-Gene	33
Sequence	5	Organism-Sequence	25
Modification	3	Organism-Modification	29

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF017874

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

family

PR:000000013 cullin

CHRD

Yes

gene

PR:000000092 fungal/metazoan cullin-1

CUL1

Yes

organism-gene

PR:O13790 cullin-1 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL1

organism-gene

PR:O60999 cullin-1 (Dictyostelium discoideum)

Dicty-CUL1

organism-gene

PR:Q12018 cell division control protein 53 (yeast)

yCUL1

organism-gene

PR:Q13616 cullin-1 (human)

hCUL1

Yes

organism-sequence

PR:Q13616-1 cullin-1 isoform 1 (human)

hCUL1/iso:1

Yes

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

organism-modification

PR:000064861 cullin-1 neddylated 1 (human)

hCUL1/Nedd:1

organism-modification

PR:000071994 cullin-1 methylated 1 (human)

hCUL1/Me:1

organism-modification

PR:000075174 cullin-1 cysteinylated 1 (human)

hCUL1/Cyst:1

organism-gene

PR:Q17389 cullin-1 (worm)

CUL1 (worm)

organism-gene

PR:Q24311 cullin homolog 1 (fruit fly)

fly-CUL1

organism-gene

PR:Q9WTX6 cullin-1 (mouse)

mCUL1

organism-sequence

PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)

mCUL1/iso:1

sequence

PR:000000267 fungal/metazoan cullin-1 isoform 1

CUL1/iso:1

organism-sequence

PR:Q13616-1 cullin-1 isoform 1 (human)

hCUL1/iso:1

Yes

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

organism-sequence

PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)

mCUL1/iso:1

modification

PR:000000427 fungal/metazoan cullin-1 isoform 1 neddylated form

CUL1/iso:1/NeddLys+

modification

PR:000000542 fungal/metazoan cullin-1 isoform 1 neddylated 1

CUL1/iso:1/Nedd:1

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

gene

PR:000006047 cullin-2

CUL2

organism-gene

PR:P0CH31 putative cullin-like protein 1 (Arabidopsis thaliana)

At-CUL2

organism-gene

PR:Q13617 cullin-2 (human)

hCUL2

organism-sequence

PR:Q13617-1 cullin-2 isoform 1 (human)

hCUL2/iso:1

organism-sequence

PR:Q13617-2 cullin-2 isoform h2 (human)

hCUL2/iso:h2

organism-modification

PR:000064774 cullin-2 neddylated 1 (human)

hCUL2/Nedd:1

organism-modification

PR:000068780 cullin-2 cysteinylated 1 (human)

hCUL2/Cyst:1

organism-modification

PR:000077772 cullin-2 deaminated 1 (human)

hCUL2/Deam:1

organism-gene

PR:Q17390 cullin-2 (worm)

CUL2 (worm)

organism-sequence

PR:Q17390-1 cullin-2 isoform c (worm)

CUL2/iso:c (worm)

organism-sequence

PR:Q17390-2 cullin-2 isoform b (worm)

CUL2/iso:b (worm)

organism-sequence

PR:Q17390-3 cullin-2 isoform d (worm)

CUL2/iso:d (worm)

organism-gene

PR:Q9D4H8 cullin-2 (mouse)

mCUL2

organism-sequence

PR:Q9D4H8-1 cullin-2 isoform 1 (mouse)

mCUL2/iso:1

organism-sequence

PR:Q9D4H8-2 cullin-2 isoform m2 (mouse)

mCUL2/iso:m2

organism-gene

PR:Q9XZJ3 cullin-2 (Dictyostelium discoideum)

Dicty-CUL2

sequence

PR:000040461 cullin-2 isoform 1

CUL2/iso:1

organism-sequence

PR:Q13617-1 cullin-2 isoform 1 (human)

hCUL2/iso:1

organism-sequence

PR:Q9D4H8-1 cullin-2 isoform 1 (mouse)

mCUL2/iso:1

gene

PR:000006048 cullin-3

CUL3

organism-gene

PR:B5DF89 cullin-3 (rat)

rCUL3

organism-sequence

PR:B5DF89-1 cullin-3 isoform 1 (rat)

rCUL3/iso:1

organism-gene

PR:Q09760 cullin-3 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL3

organism-gene

PR:Q13618 cullin-3 (human)

hCUL3

organism-sequence

PR:Q13618-1 cullin-3 isoform 1 (human)

hCUL3/iso:1

organism-sequence

PR:Q13618-2 cullin-3 isoform h2 (human)

hCUL3/iso:h2

organism-sequence

PR:Q13618-3 cullin-3 isoform h3 (human)

hCUL3/iso:h3

organism-modification

PR:000064684 cullin-3 neddylated 1 (human)

hCUL3/Nedd:1

organism-modification

PR:000067292 cullin-3 methylated 1 (human)

hCUL3/Me:1

organism-modification

PR:000085248 cullin-3 phosphorylated 1 (human)

hCUL3/Phos:1

organism-gene

PR:Q17391 cullin-3 (worm)

CUL3 (worm)

organism-gene

PR:Q54NZ5 cullin-3 (Dictyostelium discoideum)

Dicty-CUL3

organism-gene

PR:Q9JLV5 cullin-3 (mouse)

mCUL3

organism-sequence

PR:Q9JLV5-1 cullin-3 isoform 1 (mouse)

mCUL3/iso:1

organism-modification

PR:000078698 cullin-3 glutathionylated 1 (mouse)

mCUL3/SGlt:1

sequence

PR:000040462 cullin-3 isoform 1

CUL3/iso:1

organism-sequence

PR:B5DF89-1 cullin-3 isoform 1 (rat)

rCUL3/iso:1

organism-sequence

PR:Q13618-1 cullin-3 isoform 1 (human)

hCUL3/iso:1

organism-sequence

PR:Q9JLV5-1 cullin-3 isoform 1 (mouse)

mCUL3/iso:1

gene

PR:000006049 cullin-4A

CUL4A

organism-gene

PR:Q13619 cullin-4A (human)

hCUL4A

organism-sequence

PR:Q13619-1 cullin-4A isoform 1 (human)

hCUL4A/iso:1

organism-sequence

PR:Q13619-2 cullin-4A isoform h2 (human)

hCUL4A/iso:h2

organism-modification

PR:000064856 cullin-4A neddylated 1 (human)

hCUL4A/Nedd:1

organism-modification

PR:000067428 cullin-4A deaminated 1 (human)

hCUL4A/Deam:1

organism-modification

PR:000068427 cullin-4A deaminated 2 (human)

hCUL4A/Deam:2

organism-modification

PR:000075755 cullin-4A cysteinylated 1 (human)

hCUL4A/Cyst:1

organism-modification

PR:000077321 cullin-4A methylated 1 (human)

hCUL4A/Me:1

organism-modification

PR:000080495 cullin-4A methylated 2 (human)

hCUL4A/Me:2

organism-modification

PR:000083127 cullin-4A methylated 3 (human)

hCUL4A/Me:3

organism-gene

PR:Q17392 cullin-4 (worm)

CUL4A (worm)

organism-gene

PR:Q3TCH7 cullin-4A (mouse)

mCUL4A

organism-sequence

PR:Q3TCH7-1 cullin-4A isoform 1 (mouse)

mCUL4A/iso:1

organism-gene

PR:Q54CS2 cullin-4 (Dictyostelium discoideum)

Dicty-CUL4A

sequence

PR:000040463 cullin-4A isoform 1

CUL4A/iso:1

organism-sequence

PR:Q13619-1 cullin-4A isoform 1 (human)

hCUL4A/iso:1

organism-sequence

PR:Q3TCH7-1 cullin-4A isoform 1 (mouse)

mCUL4A/iso:1

gene

PR:000006050 cullin-4B

CUL4B

organism-gene

PR:A2A432 cullin-4B (mouse)

mCUL4B

organism-sequence

PR:A2A432-1 cullin-4B isoform m1 (mouse)

mCUL4B/iso:m1

organism-sequence

PR:A2A432-2 cullin-4B isoform m2 (mouse)

mCUL4B/iso:m2

organism-gene

PR:Q13620 cullin-4B (human)

hCUL4B

organism-sequence

PR:Q13620-1 cullin-4B isoform h2 (human)

hCUL4B/iso:h2

organism-sequence

PR:Q13620-2 cullin-4B isoform h1 (human)

hCUL4B/iso:h1

organism-sequence

PR:Q13620-3 cullin-4B isoform h3 (human)

hCUL4B/iso:h3

organism-modification

PR:000064654 cullin-4B neddylated 1 (human)

hCUL4B/Nedd:1

organism-modification

PR:000071773 cullin-4B methylated 1 (human)

hCUL4B/Me:1

organism-modification

PR:000078291 cullin-4B methylated 2 (human)

hCUL4B/Me:2

organism-modification

PR:000085504 cullin-4B cysteinylated 1 (human)

hCUL4B/Cyst:1

gene

PR:000006051 cullin-5

CUL5

organism-gene

PR:Q23639 cullin-5 (worm)

CUL5 (worm)

organism-gene

PR:Q93034 cullin-5 (human)

hCUL5

organism-sequence

PR:Q93034-1 cullin-5 isoform 1 (human)

hCUL5/iso:1

organism-modification

PR:000046016 cullin-5 phosphorylated 1 (human)

hCUL5/Phos:1

organism-modification

PR:000047101 cullin-5, initiator methionine removed form (human)

hCUL5/InitMet-

organism-modification

PR:000064753 cullin-5, initiator methionine removed neddylated 1 (human)

hCUL5/InitMet-/Nedd:1

organism-modification

PR:000066894 cullin-5 phosphorylated 2 (human)

hCUL5/Phos:2

organism-modification

PR:000072994 cullin-5 deaminated 1 (human)

hCUL5/Deam:1

organism-modification

PR:000075222 cullin-5 hydroxylated 1 (human)

hCUL5/Hy:1

organism-gene

PR:Q9D5V5 cullin-5 (mouse)

mCUL5

organism-sequence

PR:Q9D5V5-1 cullin-5 isoform 1 (mouse)

mCUL5/iso:1

organism-gene

PR:Q9JJ31 cullin-5 (rat)

rCUL5

organism-sequence

PR:Q9JJ31-1 cullin-5 isoform 1 (rat)

rCUL5/iso:1

sequence

PR:000042373 cullin-5 isoform 1

CUL5/iso:1

organism-sequence

PR:Q93034-1 cullin-5 isoform 1 (human)

hCUL5/iso:1

organism-sequence

PR:Q9D5V5-1 cullin-5 isoform 1 (mouse)

mCUL5/iso:1

organism-sequence

PR:Q9JJ31-1 cullin-5 isoform 1 (rat)

rCUL5/iso:1

gene

PR:000027962 plant cullin-1

plantCUL1

organism-gene

PR:Q94AH6 cullin-1 (Arabidopsis thaliana)

At-CUL1

organism-modification

PR:000027977 cullin-1 rubylated 1 (Arabidopsis thaliana)

At-plantCUL1/Ruby:1

Yes

modification

PR:000027976 plant cullin-1 rubylated 1

plantCUL1/Ruby:1

organism-modification

PR:000027977 cullin-1 rubylated 1 (Arabidopsis thaliana)

At-plantCUL1/Ruby:1

Yes

gene

PR:000028495 plant cullin-3A

CUL3A

organism-gene

PR:Q9ZVH4 cullin-3A (Arabidopsis thaliana)

At-CUL3A

gene

PR:000028497 plant cullin-3B

CUL3B

organism-gene

PR:Q9C9L0 cullin-3B (Arabidopsis thaliana)

At-CUL3B

gene

PR:000028499 plant cullin-4

CUL4

organism-gene

PR:Q8LGH4 cullin-4 (Arabidopsis thaliana)

At-CUL4

Yes

gene

PR:000028501 plant cullin-2

plantCUL2

organism-gene

PR:Q9SRZ0 cullin-2 (Arabidopsis thaliana)

At-plantCUL2

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CHRD forms found in complexes

CHRD Component	Complexes
PR:000027977 At-plantCUL1/Ruby:1	PR:000028458 SCF(TIR1) complex (Arabidopsis thaliana)
PR:000027977 At-plantCUL1/Ruby:1	PR:000028465 SCF(COI1) complex (Arabidopsis thaliana)
PR:Q13616 hCUL1	PR:000026771 SCF beta-TrCP complex (human)
	PR:000026772 SCF(Skp2) complex (human)
	PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
PR:Q8LGH4 At-CUL4	PR:000037419 ABD1:DDB1B:CUL4 (Arabidopsis thaliana)

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000013 CHRD	located_in	GO:0031461 cullin-RING ubiquitin ligase complex	PIRSF:PIRSF017874
PR:000000092 CUL1	acts_upstream_of_or_within	GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PANTHER:PTHR11932
PR:000000092 CUL1	located_in	GO:0019005 SCF ubiquitin ligase complex	PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 UniProtKB:Q13616-1, Lys-720, MOD:01150	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:8681378
		GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:10713156; PMID:10921923
		GO:0051726 regulation of cell cycle	PMID:8681378
		GO:0097193 intrinsic apoptotic signaling pathway	PMID:8681378
	located_in	GO:0019005 SCF ubiquitin ligase complex	PMID:10713156; PMID:10921923; PMID:17098746
PR:Q13616-1 hCUL1/iso:1	enables	GO:0005515 protein binding with PR:P62877-1	PMID:12504026; PMID:15537541
	enables	GO:0005515 protein binding with PR:Q86VP6-1	PMID:12504026; PMID:15537541
	located_in	NOT GO:0019005 SCF ubiquitin ligase complex	PMID:10713156; PMID:10921923; PMID:12504026