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Protein Ontology report - cullin
PR:000000013 - http://purl.obolibrary.org/obo/PR_000000013
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000013   
  PRO namecullin 
  Definition"A protein that has a core domain composition consisting of a cullin domain that functions as a molecular scaffold responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases." [PIRSF:PIRSF017874
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene11                                                  Organism-Gene 33                                        
         Sequence5                                                  Organism-Sequence 25                                        
         Modification3                                                  Organism-Modification 29                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF017874
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000000013

cullin

CHRD


"A protein that has a core domain composition consisting of a cullin domain that functions as a molecular scaffold responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases." [PIRSF:PIRSF017874]

Yes

gene



PR:000000092

fungal/metazoan cullin-1

CUL1


"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA]

Yes

organism-gene



PR:O13790

cullin-1 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O13790, PRO:DNx]


organism-gene



PR:O60999

cullin-1 (Dictyostelium discoideum)

Dicty-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of Dictyostelium discoideum." [OMA:O60999, PRO:DNx]


organism-gene



PR:Q12018

cell division control protein 53 (yeast)

yCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of yeast." [OMA:Q12018, PRO:DNx]


organism-gene



PR:Q13616

cullin-1 (human)

hCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:Q13616-1

cullin-1 isoform 1 (human)

hCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

organism-modification



PR:000064861

cullin-1 neddylated 1 (human)

hCUL1/Nedd:1


"A cullin-1 (human) that has been neddylated on the residue at the position equivalent to Lys-720 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Lys-720, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952519]


organism-modification



PR:000071994

cullin-1 methylated 1 (human)

hCUL1/Me:1


"A cullin-1 (human) that has been methylated on the residue at the position equivalent to Cys-355 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-355, MOD:00660." [IEDB_epitope:1020279, PRO:DNx]


organism-modification



PR:000075174

cullin-1 cysteinylated 1 (human)

hCUL1/Cyst:1


"A cullin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-551 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-551, MOD:00765." [IEDB_epitope:1583373, IEDB_epitope:1593153, PRO:DNx]


organism-gene



PR:Q17389

cullin-1 (worm)

CUL1 (worm)


"A fungal/metazoan cullin-1 that is encoded in the genome of worm." [OMA:Q17389, PRO:DNx]


organism-gene



PR:Q24311

cullin homolog 1 (fruit fly)

fly-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of fruit fly." [OMA:Q24311, PRO:DNx]


organism-gene



PR:Q9WTX6

cullin-1 (mouse)

mCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of mouse." [OMA:Q9WTX6, PRO:DNx]


organism-sequence



PR:Q9WTX6-1

cullin-1 isoform 1 (mouse)

mCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000267

fungal/metazoan cullin-1 isoform 1

CUL1/iso:1


"A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13616-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q13616-1

cullin-1 isoform 1 (human)

hCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

organism-sequence



PR:Q9WTX6-1

cullin-1 isoform 1 (mouse)

mCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000427

fungal/metazoan cullin-1 isoform 1 neddylated form

CUL1/iso:1/NeddLys+


"A fungal/metazoan cullin-1 isoform 1 that includes at least one neddylated lysine." [PRO:CNA]


modification



PR:000000542

fungal/metazoan cullin-1 isoform 1 neddylated 1

CUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated form that has been neddylated in the conserved Lys residue within the IVR[ILV]MKxR[RK] motif. Example: UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156]


organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

gene



PR:000006047

cullin-2

CUL2


"A cullin that is a translation product of the human CUL2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P0CH31

putative cullin-like protein 1 (Arabidopsis thaliana)

At-CUL2


"A cullin-2 that is encoded in the genome of Arabidopsis thaliana." [PRO:DNx]


organism-gene



PR:Q13617

cullin-2 (human)

hCUL2


"A cullin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13617]


organism-sequence



PR:Q13617-1

cullin-2 isoform 1 (human)

hCUL2/iso:1


"A cullin-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q13617-2

cullin-2 isoform h2 (human)

hCUL2/iso:h2


"A cullin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13617-2." [PRO:DNx, UniProtKB:Q13617]


organism-modification



PR:000064774

cullin-2 neddylated 1 (human)

hCUL2/Nedd:1


"A cullin-2 (human) that has been neddylated on the residue at the position equivalent to Lys-689 of the amino acid sequence represented by UniProtKB:Q13617-1. Example: UniProtKB:Q13617-1, Lys-689, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952511]


organism-modification



PR:000068780

cullin-2 cysteinylated 1 (human)

hCUL2/Cyst:1


"A cullin-2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-46 of the amino acid sequence represented by UniProtKB:Q13617-1. Example: UniProtKB:Q13617-1, Cys-46, MOD:00765." [IEDB_epitope:1564209, PRO:DNx]


organism-modification



PR:000077772

cullin-2 deaminated 1 (human)

hCUL2/Deam:1


"A cullin-2 (human) that has been deaminated on the residue at the position equivalent to Gln-156 of the amino acid sequence represented by UniProtKB:Q13617-1. Example: UniProtKB:Q13617-1, Gln-156, MOD:00685." [IEDB_epitope:1854126, PRO:DNx]


organism-gene



PR:Q17390

cullin-2 (worm)

CUL2 (worm)


"A cullin-2 that is encoded in the genome of worm." [OMA:Q17390, PRO:DNx]


organism-sequence



PR:Q17390-1

cullin-2 isoform c (worm)

CUL2/iso:c (worm)


"A cullin-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17390-1." [PRO:DNx, UniProtKB:Q17390]


organism-sequence



PR:Q17390-2

cullin-2 isoform b (worm)

CUL2/iso:b (worm)


"A cullin-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17390-2." [PRO:DNx, UniProtKB:Q17390]


organism-sequence



PR:Q17390-3

cullin-2 isoform d (worm)

CUL2/iso:d (worm)


"A cullin-2 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17390-3." [PRO:DNx, UniProtKB:Q17390]


organism-gene



PR:Q9D4H8

cullin-2 (mouse)

mCUL2


"A cullin-2 that is encoded in the genome of mouse." [OMA:Q9D4H8, PRO:DNx]


organism-sequence



PR:Q9D4H8-1

cullin-2 isoform 1 (mouse)

mCUL2/iso:1


"A cullin-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9D4H8-2

cullin-2 isoform m2 (mouse)

mCUL2/iso:m2


"A cullin-2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9D4H8-2." [PRO:DNx, UniProtKB:Q9D4H8]


organism-gene



PR:Q9XZJ3

cullin-2 (Dictyostelium discoideum)

Dicty-CUL2


"A cullin-2 that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]


sequence



PR:000040461

cullin-2 isoform 1

CUL2/iso:1


"A cullin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13617-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q13617-1

cullin-2 isoform 1 (human)

hCUL2/iso:1


"A cullin-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9D4H8-1

cullin-2 isoform 1 (mouse)

mCUL2/iso:1


"A cullin-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000006048

cullin-3

CUL3


"A cullin that is a translation product of the human CUL3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:B5DF89

cullin-3 (rat)

rCUL3


"A cullin-3 that is encoded in the genome of rat." [OMA:B5DF89, PRO:DNx]


organism-sequence



PR:B5DF89-1

cullin-3 isoform 1 (rat)

rCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q09760

cullin-3 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL3


"A cullin-3 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09760, PRO:DNx]


organism-gene



PR:Q13618

cullin-3 (human)

hCUL3


"A cullin-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13618]


organism-sequence



PR:Q13618-1

cullin-3 isoform 1 (human)

hCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q13618-2

cullin-3 isoform h2 (human)

hCUL3/iso:h2


"A cullin-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13618-2." [PRO:DNx, UniProtKB:Q13618]


organism-sequence



PR:Q13618-3

cullin-3 isoform h3 (human)

hCUL3/iso:h3


"A cullin-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13618-3." [PRO:DNx, UniProtKB:Q13618]


organism-modification



PR:000064684

cullin-3 neddylated 1 (human)

hCUL3/Nedd:1


"A cullin-3 (human) that has been neddylated on the residue at the position equivalent to Lys-712 of the amino acid sequence represented by UniProtKB:Q13618-1. Example: UniProtKB:Q13618-1, Lys-712, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952516]


organism-modification



PR:000067292

cullin-3 methylated 1 (human)

hCUL3/Me:1


"A cullin-3 (human) that has been methylated on the residue at the position equivalent to Cys-298 of the amino acid sequence represented by UniProtKB:Q13618-1. Example: UniProtKB:Q13618-1, Cys-298, MOD:00660." [IEDB_epitope:1026994, PRO:DNx]


organism-modification



PR:000085248

cullin-3 phosphorylated 1 (human)

hCUL3/Phos:1


"A cullin-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-713 of the amino acid sequence represented by UniProtKB:Q13618-1. Example: UniProtKB:Q13618-1, Ser-713, MOD:00046." [IEDB_epitope:2146827, PRO:DNx]


organism-gene



PR:Q17391

cullin-3 (worm)

CUL3 (worm)


"A cullin-3 that is encoded in the genome of worm." [OMA:Q17391, PRO:DNx]


organism-gene



PR:Q54NZ5

cullin-3 (Dictyostelium discoideum)

Dicty-CUL3


"A cullin-3 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54NZ5, PRO:DNx]


organism-gene



PR:Q9JLV5

cullin-3 (mouse)

mCUL3


"A cullin-3 that is encoded in the genome of mouse." [OMA:Q9JLV5, PRO:DNx]


organism-sequence



PR:Q9JLV5-1

cullin-3 isoform 1 (mouse)

mCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-modification



PR:000078698

cullin-3 glutathionylated 1 (mouse)

mCUL3/SGlt:1


"A cullin-3 (mouse) that has been glutathionylated on the residue at the position equivalent to Cys-187 of the amino acid sequence represented by UniProtKB:Q9JLV5. UniProtKB:Q9JLV5, Cys-187, MOD:00234." [IEDB_epitope:422339, PRO:DNx]


sequence



PR:000040462

cullin-3 isoform 1

CUL3/iso:1


"A cullin-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13618-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:B5DF89-1

cullin-3 isoform 1 (rat)

rCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q13618-1

cullin-3 isoform 1 (human)

hCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9JLV5-1

cullin-3 isoform 1 (mouse)

mCUL3/iso:1


"A cullin-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000006049

cullin-4A

CUL4A


"A cullin that is a translation product of the human CUL4A gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q13619

cullin-4A (human)

hCUL4A


"A cullin-4A that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13619]


organism-sequence



PR:Q13619-1

cullin-4A isoform 1 (human)

hCUL4A/iso:1


"A cullin-4A isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q13619-2

cullin-4A isoform h2 (human)

hCUL4A/iso:h2


"A cullin-4A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13619-2." [PRO:DNx, UniProtKB:Q13619]


organism-modification



PR:000064856

cullin-4A neddylated 1 (human)

hCUL4A/Nedd:1


"A cullin-4A (human) that has been neddylated on the residue at the position equivalent to Lys-705 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Lys-705, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952514]


organism-modification



PR:000067428

cullin-4A deaminated 1 (human)

hCUL4A/Deam:1


"A cullin-4A (human) that has been deaminated on the residue at the position equivalent to Gln-145 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Gln-145, MOD:00685." [IEDB_epitope:1584505, PRO:DNx]


organism-modification



PR:000068427

cullin-4A deaminated 2 (human)

hCUL4A/Deam:2


"A cullin-4A (human) that has been deaminated on the residue at the position equivalent to Asn-721 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Asn-721, MOD:00684." [IEDB_epitope:1753688, PRO:DNx]


organism-modification



PR:000075755

cullin-4A cysteinylated 1 (human)

hCUL4A/Cyst:1


"A cullin-4A (human) that has been cysteinylated on the residue at the position equivalent to Cys-241 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Cys-241, MOD:00765." [IEDB_epitope:1012185, PRO:DNx]


organism-modification



PR:000077321

cullin-4A methylated 1 (human)

hCUL4A/Me:1


"A cullin-4A (human) that has been methylated on the residue at the position equivalent to Cys-143 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Cys-143, MOD:00660." [IEDB_epitope:1005130, PRO:DNx]


organism-modification



PR:000080495

cullin-4A methylated 2 (human)

hCUL4A/Me:2


"A cullin-4A (human) that has been methylated on the residue at the position equivalent to Cys-241 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Cys-241, MOD:00660." [IEDB_epitope:1012186, IEDB_epitope:1023933, PRO:DNx]


organism-modification



PR:000083127

cullin-4A methylated 3 (human)

hCUL4A/Me:3


"A cullin-4A (human) that has been methylated on the residue at the position equivalent to Cys-633 of the amino acid sequence represented by UniProtKB:Q13619-1. Example: UniProtKB:Q13619-1, Cys-633, MOD:00660." [IEDB_epitope:1028071, PRO:DNx]


organism-gene



PR:Q17392

cullin-4 (worm)

CUL4A (worm)


"A cullin-4A that is encoded in the genome of worm." [PRO:DNx]


organism-gene



PR:Q3TCH7

cullin-4A (mouse)

mCUL4A


"A cullin-4A that is encoded in the genome of mouse." [OMA:Q3TCH7, PRO:DNx]


organism-sequence



PR:Q3TCH7-1

cullin-4A isoform 1 (mouse)

mCUL4A/iso:1


"A cullin-4A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q54CS2

cullin-4 (Dictyostelium discoideum)

Dicty-CUL4A


"A cullin-4A that is encoded in the genome of Dictyostelium discoideum." [PRO:DNx]


sequence



PR:000040463

cullin-4A isoform 1

CUL4A/iso:1


"A cullin-4A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13619-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q13619-1

cullin-4A isoform 1 (human)

hCUL4A/iso:1


"A cullin-4A isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q3TCH7-1

cullin-4A isoform 1 (mouse)

mCUL4A/iso:1


"A cullin-4A isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000006050

cullin-4B

CUL4B


"A cullin that is a translation product of the human CUL4B gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:A2A432

cullin-4B (mouse)

mCUL4B


"A cullin-4B that is encoded in the genome of mouse." [OMA:A2A432, PRO:DNx]


organism-sequence



PR:A2A432-1

cullin-4B isoform m1 (mouse)

mCUL4B/iso:m1


"A cullin-4B (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2A432-1." [PRO:DNx, UniProtKB:A2A432]


organism-sequence



PR:A2A432-2

cullin-4B isoform m2 (mouse)

mCUL4B/iso:m2


"A cullin-4B (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2A432-2." [PRO:DNx, UniProtKB:A2A432]


organism-gene



PR:Q13620

cullin-4B (human)

hCUL4B


"A cullin-4B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13620]


organism-sequence



PR:Q13620-1

cullin-4B isoform h2 (human)

hCUL4B/iso:h2


"A cullin-4B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13620-1." [PRO:DNx, UniProtKB:Q13620]


organism-sequence



PR:Q13620-2

cullin-4B isoform h1 (human)

hCUL4B/iso:h1


"A cullin-4B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13620-2." [PRO:DNx, UniProtKB:Q13620]


organism-sequence



PR:Q13620-3

cullin-4B isoform h3 (human)

hCUL4B/iso:h3


"A cullin-4B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13620-3." [PRO:DNx, UniProtKB:Q13620]


organism-modification



PR:000064654

cullin-4B neddylated 1 (human)

hCUL4B/Nedd:1


"A cullin-4B (human) that has been neddylated on the residue at the position equivalent to Lys-859 of the amino acid sequence represented by UniProtKB:Q13620-2. Example: UniProtKB:Q13620-2, Lys-859, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952522]


organism-modification



PR:000071773

cullin-4B methylated 1 (human)

hCUL4B/Me:1


"A cullin-4B (human) that has been methylated on the residue at the position equivalent to Cys-533 of the amino acid sequence represented by UniProtKB:Q13620-2. Example: UniProtKB:Q13620-2, Cys-533, MOD:00660." [IEDB_epitope:1005143, PRO:DNx]


organism-modification



PR:000078291

cullin-4B methylated 2 (human)

hCUL4B/Me:2


"A cullin-4B (human) that has been methylated on the residue at the position equivalent to Cys-730 of the amino acid sequence represented by UniProtKB:Q13620-2. Example: UniProtKB:Q13620-2, Cys-730, MOD:00660." [IEDB_epitope:1052150, PRO:DNx]


organism-modification



PR:000085504

cullin-4B cysteinylated 1 (human)

hCUL4B/Cyst:1


"A cullin-4B (human) that has been cysteinylated on the residue at the position equivalent to Cys-248 of the amino acid sequence represented by UniProtKB:Q13620-2. Example: UniProtKB:Q13620-2, Cys-248, MOD:00765." [IEDB_epitope:1583782, PRO:DNx]


gene



PR:000006051

cullin-5

CUL5


"A cullin that is a translation product of the human CUL5 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q23639

cullin-5 (worm)

CUL5 (worm)


"A cullin-5 that is encoded in the genome of worm." [OMA:Q23639, PRO:DNx]


organism-gene



PR:Q93034

cullin-5 (human)

hCUL5


"A cullin-5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q93034]


organism-sequence



PR:Q93034-1

cullin-5 isoform 1 (human)

hCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000046016

cullin-5 phosphorylated 1 (human)

hCUL5/Phos:1


"A cullin-5 (human) that has been phosphorylated at Ser-730. UniProtKB:Q93034, Ser-730, MOD:00046." [iPTMnet:Q93034, PMID:10898738]


organism-modification



PR:000047101

cullin-5, initiator methionine removed form (human)

hCUL5/InitMet-


"A cullin-5 (human) that has had the initiator methionine removed. UniProtKB:Q93034, 2-780." [PRO:DNx, Reactome:R-HSA-180528]


organism-modification



PR:000064753

cullin-5, initiator methionine removed neddylated 1 (human)

hCUL5/InitMet-/Nedd:1


"A cullin-5 (human) that has had the initiator methionine removed and that has been neddylated on the residue at the position equivalent to Lys-724 of the amino acid sequence represented by UniProtKB:Q93034. UniProtKB:Q93034, 2-780, Lys-724, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952014]


organism-modification



PR:000066894

cullin-5 phosphorylated 2 (human)

hCUL5/Phos:2


"A cullin-5 (human) that has been phosphorylated on the residue at the position equivalent to Thr-346 of the amino acid sequence represented by UniProtKB:Q93034. UniProtKB:Q93034, Thr-346, MOD:00047." [IEDB_epitope:2147463, PRO:DNx]


organism-modification



PR:000072994

cullin-5 deaminated 1 (human)

hCUL5/Deam:1


"A cullin-5 (human) that has been deaminated on the residue at the position equivalent to Gln-756 of the amino acid sequence represented by UniProtKB:Q93034. UniProtKB:Q93034, Gln-756, MOD:00685." [IEDB_epitope:1766608, PRO:DNx]


organism-modification



PR:000075222

cullin-5 hydroxylated 1 (human)

hCUL5/Hy:1


"A cullin-5 (human) that has been hydroxylated on the residue at the position equivalent to Trp-53 of the amino acid sequence represented by UniProtKB:Q93034. UniProtKB:Q93034, Trp-53, MOD:01622." [IEDB_epitope:1321492, PRO:DNx]


organism-gene



PR:Q9D5V5

cullin-5 (mouse)

mCUL5


"A cullin-5 that is encoded in the genome of mouse." [OMA:Q9D5V5, PRO:DNx]


organism-sequence



PR:Q9D5V5-1

cullin-5 isoform 1 (mouse)

mCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q9JJ31

cullin-5 (rat)

rCUL5


"A cullin-5 that is encoded in the genome of rat." [OMA:Q9JJ31, PRO:DNx]


organism-sequence



PR:Q9JJ31-1

cullin-5 isoform 1 (rat)

rCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


sequence



PR:000042373

cullin-5 isoform 1

CUL5/iso:1


"A cullin-5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q93034-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q93034-1

cullin-5 isoform 1 (human)

hCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9D5V5-1

cullin-5 isoform 1 (mouse)

mCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9JJ31-1

cullin-5 isoform 1 (rat)

rCUL5/iso:1


"A cullin-5 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


gene



PR:000027962

plant cullin-1

plantCUL1


"A cullin that is a translation product of the Arabidopsis thaliana CUL1 gene or a 1:1 ortholog thereof in plants." [PRO:PD]


organism-gene



PR:Q94AH6

cullin-1 (Arabidopsis thaliana)

At-CUL1


"A plant cullin-1 that is encoded in the genome of Arabidopsis thaliana." [PRO:PD, UniProtKB:Q94AH6]


organism-modification



PR:000027977

cullin-1 rubylated 1 (Arabidopsis thaliana)

At-plantCUL1/Ruby:1


"A plant cullin-1 rubylated 1 in Arabidopsis thaliana. UniProtKB:Q94AH6, Lys-682, MOD:01150." [PMID:10611386, PRO:CNA]


Yes
modification



PR:000027976

plant cullin-1 rubylated 1

plantCUL1/Ruby:1


"A plant cullin-1 that has been rubylated on the Lys residue within the conserved sequence VR[IV]MK to promote the activation of SCF E3 ubiquitin ligase complexes for subsequent proteasomal degradation of target proteins. Example: UniProtKB:Q94AH6, Lys-682, MOD:01150." [PMID:10611386, PRO:CNA]


organism-modification



PR:000027977

cullin-1 rubylated 1 (Arabidopsis thaliana)

At-plantCUL1/Ruby:1


"A plant cullin-1 rubylated 1 in Arabidopsis thaliana. UniProtKB:Q94AH6, Lys-682, MOD:01150." [PMID:10611386, PRO:CNA]


Yes
gene



PR:000028495

plant cullin-3A

CUL3A


"A cullin that is a translation product of the Arabidopsis thaliana CUL3A gene or a 1:1 ortholog thereof in plants." [PMID:12795696, PRO:CNA]


organism-gene



PR:Q9ZVH4

cullin-3A (Arabidopsis thaliana)

At-CUL3A


"A plant cullin-3A that is encoded in the genome of Arabidopsis thaliana." [PMID:12795696, PRO:CNA]


gene



PR:000028497

plant cullin-3B

CUL3B


"A cullin that is a translation product of the Arabidopsis thaliana CUL3B gene or a 1:1 ortholog thereof in plants." [PMID:12795696, PRO:CNA]


organism-gene



PR:Q9C9L0

cullin-3B (Arabidopsis thaliana)

At-CUL3B


"A plant cullin-3B that is encoded in the genome of Arabidopsis thaliana." [PMID:12795696, PRO:CNA]


gene



PR:000028499

plant cullin-4

CUL4


"A cullin that is a translation product of the Arabidopsis thaliana CUL4 gene or a 1:1 ortholog thereof in plants." [PMID:12795696, PRO:CNA]


organism-gene



PR:Q8LGH4

cullin-4 (Arabidopsis thaliana)

At-CUL4


"A plant cullin-4 that is encoded in the genome of Arabidopsis thaliana." [PMID:12795696, PRO:CNA]


Yes
gene



PR:000028501

plant cullin-2

plantCUL2


"A cullin that is a translation product of the Arabidopsis thaliana CUL2 gene or a 1:1 ortholog thereof in plants." [PMID:12795696, PRO:CNA]


organism-gene



PR:Q9SRZ0

cullin-2 (Arabidopsis thaliana)

At-plantCUL2


"A plant cullin-2 that is encoded in the genome of Arabidopsis thaliana." [PMID:12795696, PRO:CNA]


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CHRD forms found in complexes   

CHRD Component
Complexes
PR:000027977 At-plantCUL1/Ruby:1 PR:000028458 SCF(TIR1) complex (Arabidopsis thaliana)
PR:000028465 SCF(COI1) complex (Arabidopsis thaliana)
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
PR:Q8LGH4 At-CUL4 PR:000037419 ABD1:DDB1B:CUL4 (Arabidopsis thaliana)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0008285 negative regulation of cell population proliferationPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processPR:000000092 CUL1 PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cyclePR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathwayPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0019005 SCF ubiquitin ligase complexPR:000000092 CUL1 PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923; PMID:17098746
NOT GO:0019005 SCF ubiquitin ligase complexPR:Q13616-1 hCUL1/iso:1 PMID:10713156; PMID:10921923; PMID:12504026
GO:0031461 cullin-RING ubiquitin ligase complexPR:000000013 CHRD PIRSF:PIRSF017874