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Protein Ontology report - HECT domain-containing E3 ubiquitin-protein ligase with WW domains
PR:000000016 - http://purl.obolibrary.org/obo/PR_000000016
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000016   
  PRO nameHECT domain-containing E3 ubiquitin-protein ligase with WW domains 
  Definition"A protein that has a core domain composition consisting of the C-terminal HECT-domain (ubiquitin-transferase) (Pfam:PF00632), which is catalytically involved in the attachment of ubiquitin to substrate proteins, and an N-terminal extension with a C2 domain (Pfam:PF00168) and two to three copies of the WW domain (Pfam:PF00397) that mediate the substrate specificity." [PMID:18047743] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 19                                        
         Sequence3                                                  Organism-Sequence 41                                        
         Modification1                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001569
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000016 HECT domain-containing E3 ubiquitin-protein ligase with WW domains
FST
Yes
family


PR:000000127 smad ubiquitination regulatory factor
ACVRL1
Yes
gene


PR:000000361 E3 ubiquitin-protein ligase SMURF1
SMURF1

organism-gene


PR:Q9CUN6 E3 ubiquitin-protein ligase SMURF1 (mouse)
mSMURF1
Yes
organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-modification


PR:000049754 E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse)
mSMURF1/Phos:1

organism-modification


PR:000049755 E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse)
mSMURF1/UnPhos:1

organism-gene


PR:Q9HCE7 E3 ubiquitin-protein ligase SMURF1 (human)
hSMURF1
Yes
organism-sequence


PR:Q9HCE7-1 E3 ubiquitin-protein ligase SMURF1 isoform Long (human)
hSMURF1/iso:Long

organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
organism-modification


PR:000075773 E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)
hSMURF1/Cyst:1

organism-gene


PR:Q9V853 E3 ubiquitin-protein ligase Smurf1 (fruit fly)
fly-SMURF1

sequence


PR:000000466 E3 ubiquitin-protein ligase SMURF1 isoform Short
SMURF1/iso:Short

organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
gene


PR:000000362 E3 ubiquitin-protein ligase SMURF2
SMURF2

organism-gene


PR:A2A5Z6 E3 ubiquitin-protein ligase SMURF2 (mouse)
mSMURF2

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1

organism-sequence


PR:A2A5Z6-2 E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse)
mSMURF2/iso:m2

organism-gene


PR:A9JRZ0 E3 ubiquitin-protein ligase SMURF2 (zebrafish)
z-SMURF2

organism-gene


PR:Q9HAU4 E3 ubiquitin-protein ligase SMURF2 (human)
hSMURF2
Yes
organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1

sequence


PR:000043363 E3 ubiquitin-protein ligase SMURF2 isoform 1
SMURF2/iso:1

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1

organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1

gene


PR:000003174 NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1

organism-gene


PR:Q8BZZ3 NEDD4-like E3 ubiquitin-protein ligase WWP1 (mouse)
mWWP1

organism-gene


PR:Q9H0M0 NEDD4-like E3 ubiquitin-protein ligase WWP1 (human)
hWWP1

organism-sequence


PR:Q9H0M0-1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h1 (human)
hWWP1/iso:h1

organism-sequence


PR:Q9H0M0-2 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h2 (human)
hWWP1/iso:h2

organism-sequence


PR:Q9H0M0-3 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h3 (human)
hWWP1/iso:h3

organism-sequence


PR:Q9H0M0-4 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h4 (human)
hWWP1/iso:h4

organism-sequence


PR:Q9H0M0-5 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h5 (human)
hWWP1/iso:h5

organism-sequence


PR:Q9H0M0-6 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h6 (human)
hWWP1/iso:h6

organism-modification


PR:000081799 NEDD4-like E3 ubiquitin-protein ligase WWP1 deaminated 1 (human)
hWWP1/Deam:1

organism-gene


PR:Q9N2Z7 E3 ubiquitin-protein ligase wwp-1 (worm)
WWP1 (worm)

organism-sequence


PR:Q9N2Z7-1 E3 ubiquitin-protein ligase wwp-1 isoform a (worm)
WWP1/iso:a (worm)

organism-sequence


PR:Q9N2Z7-2 E3 ubiquitin-protein ligase wwp-1 isoform b (worm)
WWP1/iso:b (worm)

organism-sequence


PR:Q9N2Z7-3 E3 ubiquitin-protein ligase wwp-1 isoform c (worm)
WWP1/iso:c (worm)

organism-sequence


PR:Q9N2Z7-4 E3 ubiquitin-protein ligase wwp-1 isoform d (worm)
WWP1/iso:d (worm)

gene


PR:000003191 E3 ubiquitin-protein ligase NEDD4-like
NEDD4L

organism-gene


PR:Q8CFI0 E3 ubiquitin-protein ligase NEDD4-like (mouse)
mNEDD4L

organism-sequence


PR:Q8CFI0-1 E3 ubiquitin-protein ligase NEDD4-like isoform m1 (mouse)
mNEDD4L/iso:m1

organism-sequence


PR:Q8CFI0-2 E3 ubiquitin-protein ligase NEDD4-like isoform m2 (mouse)
mNEDD4L/iso:m2

organism-sequence


PR:Q8CFI0-3 E3 ubiquitin-protein ligase NEDD4-like isoform m3 (mouse)
mNEDD4L/iso:m3

organism-modification


PR:000079739 E3 ubiquitin-protein ligase NEDD4-like cysteinylated 1 (mouse)
mNEDD4L/Cyst:1

organism-gene


PR:Q96PU5 E3 ubiquitin-protein ligase NEDD4-like (human)
hNEDD4L

organism-sequence


PR:Q96PU5-1 E3 ubiquitin-protein ligase NEDD4-like isoform h1 (human)
hNEDD4L/iso:h1

organism-sequence


PR:Q96PU5-2 E3 ubiquitin-protein ligase NEDD4-like isoform h2 (human)
hNEDD4L/iso:h2

organism-sequence


PR:Q96PU5-3 E3 ubiquitin-protein ligase NEDD4-like isoform h3 (human)
hNEDD4L/iso:h3

organism-sequence


PR:Q96PU5-4 E3 ubiquitin-protein ligase NEDD4-like isoform h4 (human)
hNEDD4L/iso:h4

organism-sequence


PR:Q96PU5-5 E3 ubiquitin-protein ligase NEDD4-like isoform h5 (human)
hNEDD4L/iso:h5

organism-sequence


PR:Q96PU5-6 E3 ubiquitin-protein ligase NEDD4-like isoform h6 (human)
hNEDD4L/iso:h6

organism-sequence


PR:Q96PU5-7 E3 ubiquitin-protein ligase NEDD4-like isoform h7 (human)
hNEDD4L/iso:h7

organism-sequence


PR:Q96PU5-9 E3 ubiquitin-protein ligase NEDD4-like isoform h8 (human)
hNEDD4L/iso:h8

organism-modification


PR:000070849 E3 ubiquitin-protein ligase NEDD4-like phosphorylated 1 (human)
hNEDD4L/Phos:1

organism-modification


PR:000071377 E3 ubiquitin-protein ligase NEDD4-like phosphorylated 2 (human)
hNEDD4L/Phos:2

organism-modification


PR:000072127 E3 ubiquitin-protein ligase NEDD4-like deaminated 1 (human)
hNEDD4L/Deam:1

organism-modification


PR:000081384 E3 ubiquitin-protein ligase NEDD4-like methylated 1 (human)
hNEDD4L/Me:1

organism-modification


PR:000084556 E3 ubiquitin-protein ligase NEDD4-like phosphorylated 3 (human)
hNEDD4L/Phos:3

organism-modification


PR:000084704 E3 ubiquitin-protein ligase NEDD4-like phosphorylated 4 (human)
hNEDD4L/Phos:4

modification


PR:000018788 E3 ubiquitin-protein ligase NEDD4-like, initiator methionine removed form
NEDD4L/InitMet-

gene


PR:000003192 E3 ubiquitin-protein ligase Itchy
ITCH

organism-gene


PR:Q8C863 E3 ubiquitin-protein ligase Itchy (mouse)
mITCH

organism-sequence


PR:Q8C863-1 E3 ubiquitin-protein ligase Itchy isoform m1 (mouse)
mITCH/iso:m1

organism-sequence


PR:Q8C863-2 E3 ubiquitin-protein ligase Itchy isoform m2 (mouse)
mITCH/iso:m2

organism-gene


PR:Q96J02 E3 ubiquitin-protein ligase Itchy homolog (human)
hITCH

organism-sequence


PR:Q96J02-1 E3 ubiquitin-protein ligase Itchy homolog isoform h1 (human)
hITCH/iso:h1

organism-sequence


PR:Q96J02-2 E3 ubiquitin-protein ligase Itchy homolog isoform h2 (human)
hITCH/iso:h2

organism-sequence


PR:Q96J02-3 E3 ubiquitin-protein ligase Itchy homolog isoform h3 (human)
hITCH/iso:h3

organism-modification


PR:000066127 E3 ubiquitin-protein ligase Itchy homolog deaminated 1 (human)
hITCH/Deam:1

organism-modification


PR:000069402 E3 ubiquitin-protein ligase Itchy homolog deaminated 2 (human)
hITCH/Deam:2

organism-modification


PR:000072373 E3 ubiquitin-protein ligase Itchy homolog deaminated 3 (human)
hITCH/Deam:3

organism-modification


PR:000072566 E3 ubiquitin-protein ligase Itchy homolog deaminated 4 (human)
hITCH/Deam:4

organism-modification


PR:000080509 E3 ubiquitin-protein ligase Itchy homolog deaminated 5 (human)
hITCH/Deam:5

gene


PR:000011115 E3 ubiquitin-protein ligase NEDD4
NEDD4

organism-gene


PR:P46934 E3 ubiquitin-protein ligase NEDD4 (human)
hNEDD4

organism-sequence


PR:P46934-1 E3 ubiquitin-protein ligase NEDD4 isoform h1 (human)
hNEDD4/iso:h1

organism-sequence


PR:P46934-2 E3 ubiquitin-protein ligase NEDD4 isoform h2 (human)
hNEDD4/iso:h2

organism-sequence


PR:P46934-3 E3 ubiquitin-protein ligase NEDD4 isoform h3 (human)
hNEDD4/iso:h3

organism-sequence


PR:P46934-4 E3 ubiquitin-protein ligase NEDD4 isoform h4 (human)
hNEDD4/iso:h4

organism-modification


PR:000081259 E3 ubiquitin-protein ligase NEDD4 phosphorylated 1 (human)
hNEDD4/Phos:1

organism-gene


PR:P46935 E3 ubiquitin-protein ligase NEDD4 (mouse)
mNEDD4

organism-gene


PR:Q62940 E3 ubiquitin-protein ligase NEDD4 (rat)
rNEDD4

gene


PR:000017465 NEDD4-like E3 ubiquitin-protein ligase WWP2
WWP2

organism-gene


PR:O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 (human)
hWWP2

organism-sequence


PR:O00308-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (human)
hWWP2/iso:1

organism-sequence


PR:O00308-2 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h2 (human)
hWWP2/iso:h2

organism-sequence


PR:O00308-3 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h3 (human)
hWWP2/iso:h3

organism-sequence


PR:O00308-4 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h4 (human)
hWWP2/iso:h4

organism-modification


PR:000070658 NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 1 (human)
hWWP2/Deam:1

organism-modification


PR:000073586 NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 2 (human)
hWWP2/Deam:2

organism-modification


PR:000074527 NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 3 (human)
hWWP2/Deam:3

organism-modification


PR:000082029 NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 4 (human)
hWWP2/Deam:4

organism-modification


PR:000082609 NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 5 (human)
hWWP2/Deam:5

organism-gene


PR:P39940 E3 ubiquitin-protein ligase RSP5 (yeast)
yWWP2

organism-gene


PR:Q9DBH0 NEDD4-like E3 ubiquitin-protein ligase WWP2 (mouse)
mWWP2

organism-sequence


PR:Q9DBH0-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (mouse)
mWWP2/iso:1

sequence


PR:000037914 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1
WWP2/iso:1

organism-sequence


PR:O00308-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (human)
hWWP2/iso:1

organism-sequence


PR:Q9DBH0-1 NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (mouse)
mWWP2/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000016 FST enablesGO:0004842 ubiquitin-protein transferase activity PIRSF:PIRSF001569
PR:000000127 ACVRL1 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PIRSF:PIRSF500454
GO:0007398 ectoderm development PIRSF:PIRSF500454
GO:0009968 negative regulation of signal transduction PIRSF:PIRSF500454
PR:Q9CUN6 mSMURF1 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:14711801
PR:Q9CUN6-1 mSMURF1/iso:Short located_inGO:0005622 intracellular anatomical structure PMID:14711801
PR:Q9HAU4 hSMURF2 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:14755250
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway PMID:11016919; PMID:11158580; PMID:11163210; PMID:15862290
enablesGO:0004842 ubiquitin-protein transferase activity PMID:14755250
GO:0005515 protein binding PMID:14755250
PR:Q9HCE7 hSMURF1 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10458166
PR:Q9HCE7-2 hSMURF1/iso:Short acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0036211 protein modification process PMID:10458166
enablesGO:0004842 ubiquitin-protein transferase activity PMID:10458166
GO:0005515 protein binding PMID:11278251; PMID:16299379
located_inGO:0005622 intracellular anatomical structure PMID:10458166