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Protein Ontology report - thrombospondin subgroup B
PR:000000030 - http://purl.obolibrary.org/obo/PR_000000030
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000030   
  PRO namethrombospondin subgroup B 
  Definition"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [PMID:10842357] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 10                                        
         Sequence3                                                  Organism-Sequence 41                                        
         Modification7                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002479
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000030 thrombospondin subgroup B
NOG
Yes
gene


PR:000000085 cartilage oligomeric matrix protein
COMP

organism-gene


PR:P35444 cartilage oligomeric matrix protein (rat)
rCOMP

organism-gene


PR:P49747 cartilage oligomeric matrix protein (human)
hCOMP

organism-sequence


PR:000000231 cartilage oligomeric matrix protein sequence variant P276R (human)
hCOMP/var:P276R
Yes
organism-sequence


PR:000000232 cartilage oligomeric matrix protein sequence variant C387G (human)
hCOMP/var:C387G
Yes
organism-sequence


PR:000000233 cartilage oligomeric matrix protein sequence variant D408Y (human)
hCOMP/var:D408Y
Yes
organism-sequence


PR:000000234 cartilage oligomeric matrix protein sequence variant D420A (human)
hCOMP/var:D420A
Yes
organism-sequence


PR:000000235 cartilage oligomeric matrix protein sequence variant G440E (human)
hCOMP/var:G440E
Yes
organism-sequence


PR:000000236 cartilage oligomeric matrix protein sequence variant G440R (human)
hCOMP/var:G440R
Yes
organism-sequence


PR:000000237 cartilage oligomeric matrix protein sequence variant N453S (human)
hCOMP/var:N453S
Yes
organism-sequence


PR:000000238 cartilage oligomeric matrix protein sequence variant D439V (human)
hCOMP/var:D439V
Yes
organism-sequence


PR:000000239 cartilage oligomeric matrix protein sequence variant C468Y (human)
hCOMP/var:C468Y
Yes
organism-sequence


PR:000000240 cartilage oligomeric matrix protein sequence variant D472Y (human)
hCOMP/var:D472Y
Yes
organism-sequence


PR:000000241 cartilage oligomeric matrix protein sequence variant D473G (human)
hCOMP/var:D473G
Yes
organism-sequence


PR:000000242 cartilage oligomeric matrix protein sequence variant D290N (human)
hCOMP/var:D290N
Yes
organism-sequence


PR:000000243 cartilage oligomeric matrix protein sequence variant D482G (human)
hCOMP/var:D482G
Yes
organism-sequence


PR:000000244 cartilage oligomeric matrix protein sequence variant D518N (human)
hCOMP/var:D518N
Yes
organism-sequence


PR:000000245 cartilage oligomeric matrix protein sequence variant G719D (human)
hCOMP/var:G719D
Yes
organism-sequence


PR:000000246 cartilage oligomeric matrix protein sequence variant N523K (human)
hCOMP/var:N523K
Yes
organism-sequence


PR:000000247 cartilage oligomeric matrix protein sequence variant T585M (human)
hCOMP/var:T585M
Yes
organism-sequence


PR:000000248 cartilage oligomeric matrix protein sequence variant T585R (human)
hCOMP/var:T585R
Yes
organism-sequence


PR:000000249 cartilage oligomeric matrix protein sequence variant 26 (human)
hCOMP/var:26
Yes
organism-sequence


PR:000000250 cartilage oligomeric matrix protein sequence variant D372del (human)
hCOMP/var:D372del
Yes
organism-sequence


PR:000000251 cartilage oligomeric matrix protein sequence variant D374del (human)
hCOMP/var:D374del
Yes
organism-sequence


PR:000000252 cartilage oligomeric matrix protein sequence variant S459del (human)
hCOMP/var:S459del
Yes
organism-sequence


PR:000000253 cartilage oligomeric matrix protein sequence variant G299R (human)
hCOMP/var:G299R
Yes
organism-sequence


PR:000000254 cartilage oligomeric matrix protein sequence variant D469del (human)
hCOMP/var:D469del
Yes
organism-sequence


PR:000000255 cartilage oligomeric matrix protein sequence variant D473del (human)
hCOMP/var:D473del
Yes
organism-sequence


PR:000000256 cartilage oligomeric matrix protein sequence variant 32 (human)
hCOMP/var:32
Yes
organism-sequence


PR:000000257 cartilage oligomeric matrix protein sequence variant 33 (human)
hCOMP/var:33
Yes
organism-sequence


PR:000000258 cartilage oligomeric matrix protein sequence variant C328R (human)
hCOMP/var:C328R
Yes
organism-sequence


PR:000000259 cartilage oligomeric matrix protein sequence variant D342Y (human)
hCOMP/var:D342Y
Yes
organism-sequence


PR:000000260 cartilage oligomeric matrix protein sequence variant C348R (human)
hCOMP/var:C348R
Yes
organism-sequence


PR:000000261 cartilage oligomeric matrix protein sequence variant D361V (human)
hCOMP/var:D361V
Yes
organism-sequence


PR:000000262 cartilage oligomeric matrix protein sequence variant D361Y (human)
hCOMP/var:D361Y
Yes
organism-sequence


PR:000000263 cartilage oligomeric matrix protein sequence variant C371S (human)
hCOMP/var:C371S
Yes
organism-sequence


PR:P49747-1 cartilage oligomeric matrix protein isoform 1 (human)
hCOMP/iso:1
Yes
organism-modification


PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)
hCOMP/iso:1/SigPep-
Yes
organism-sequence


PR:P49747-2 cartilage oligomeric matrix protein isoform h2 (human)
hCOMP/iso:h2

organism-modification


PR:000056586 cartilage oligomeric matrix protein N-glycosylated 1 (human)
hCOMP/NGlyco:1

organism-modification


PR:000056587 cartilage oligomeric matrix protein N-glycosylated 2 (human)
hCOMP/NGlyco:2

organism-modification


PR:000068189 cartilage oligomeric matrix protein deaminated 1 (human)
hCOMP/Deam:1

organism-modification


PR:000073868 cartilage oligomeric matrix protein deaminated 2 (human)
hCOMP/Deam:2

organism-gene


PR:Q9R0G6 cartilage oligomeric matrix protein (mouse)
mCOMP

organism-sequence


PR:Q9R0G6-1 cartilage oligomeric matrix protein isoform 1 (mouse)
mCOMP/iso:1

sequence


PR:000000230 cartilage oligomeric matrix protein isoform 1
COMP/iso:1

organism-sequence


PR:P49747-1 cartilage oligomeric matrix protein isoform 1 (human)
hCOMP/iso:1
Yes
organism-modification


PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)
hCOMP/iso:1/SigPep-
Yes
organism-sequence


PR:Q9R0G6-1 cartilage oligomeric matrix protein isoform 1 (mouse)
mCOMP/iso:1

modification


PR:000000540 cartilage oligomeric matrix protein isoform 1, signal peptide removed form
COMP/iso:1/SigPep-

organism-modification


PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)
hCOMP/iso:1/SigPep-
Yes
modification


PR:000025416 cartilage oligomeric matrix protein proteolytic cleavage product
COMP/ClvPrd

gene


PR:000000131 thrombospondin-3
THBS3

organism-gene


PR:P49746 thrombospondin-3 (human)
hTHBS3

organism-sequence


PR:P49746-1 thrombospondin-3 isoform 1 (human)
hTHBS3/iso:1

organism-sequence


PR:P49746-2 thrombospondin-3 isoform h2 (human)
hTHBS3/iso:h2

organism-modification


PR:000049438 thrombospondin-3, signal peptide removed form (human)
hTHBS3/SigPep-

organism-modification


PR:000056585 thrombospondin-3 N-glycosylated 1 (human)
hTHBS3/NGlyco:1

organism-gene


PR:Q05895 thrombospondin-3 (mouse)
mTHBS3

organism-sequence


PR:Q05895-1 thrombospondin-3 isoform 1 (mouse)
mTHBS3/iso:1

organism-modification


PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)
mTHBS3/iso:1/SigPep-
Yes
organism-gene


PR:Q8JHW2 thrombospondin-3a (zebrafish)
z-THBS3

sequence


PR:000000378 thrombospondin-3 isoform 1
THBS3/iso:1

organism-sequence


PR:P49746-1 thrombospondin-3 isoform 1 (human)
hTHBS3/iso:1

organism-sequence


PR:Q05895-1 thrombospondin-3 isoform 1 (mouse)
mTHBS3/iso:1

organism-modification


PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)
mTHBS3/iso:1/SigPep-
Yes
modification


PR:000000594 thrombospondin-3 isoform 1, signal peptide removed form
THBS3/iso:1/SigPep-

organism-modification


PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)
mTHBS3/iso:1/SigPep-
Yes
modification


PR:000018284 thrombospondin-3, signal peptide removed form
THBS3/SigPep-

modification


PR:000000594 thrombospondin-3 isoform 1, signal peptide removed form
THBS3/iso:1/SigPep-

organism-modification


PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)
mTHBS3/iso:1/SigPep-
Yes
organism-modification


PR:000049438 thrombospondin-3, signal peptide removed form (human)
hTHBS3/SigPep-

modification


PR:000025439 thrombospondin-3 proteolytic cleavage product
THBS3/ClvPrd

gene


PR:000000132 thrombospondin-4
THBS4

organism-gene


PR:P35443 thrombospondin-4 (human)
hTHBS4

organism-sequence


PR:P35443-1 thrombospondin-4 isoform 1 (human)
hTHBS4/iso:1

organism-modification


PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)
hTHBS4/iso:1/SigPep-
Yes
organism-modification


PR:000056389 thrombospondin-4 O-glycosylated 1 (human)
hTHBS4/OGlyco:1

organism-modification


PR:000056390 thrombospondin-4 O-glycosylated 2 (human)
hTHBS4/OGlyco:2

organism-modification


PR:000056391 thrombospondin-4 O-glycosylated 3 (human)
hTHBS4/OGlyco:3

organism-modification


PR:000056392 thrombospondin-4 O-glycosylated 4 (human)
hTHBS4/OGlyco:4

organism-gene


PR:P49744 thrombospondin-4 (rat)
rTHBS4

organism-gene


PR:Q8JGW0 thrombospondin-4-B (zebrafish)
z-THBS4

organism-gene


PR:Q9Z1T2 thrombospondin-4 (mouse)
mTHBS4

organism-sequence


PR:Q9Z1T2-1 thrombospondin-4 isoform 1 (mouse)
mTHBS4/iso:1

sequence


PR:000000379 thrombospondin-4 isoform 1
THBS4/iso:1

organism-sequence


PR:P35443-1 thrombospondin-4 isoform 1 (human)
hTHBS4/iso:1

organism-modification


PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)
hTHBS4/iso:1/SigPep-
Yes
organism-sequence


PR:Q9Z1T2-1 thrombospondin-4 isoform 1 (mouse)
mTHBS4/iso:1

modification


PR:000000595 thrombospondin-4 isoform 1, signal peptide removed form
THBS4/iso:1/SigPep-

organism-modification


PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)
hTHBS4/iso:1/SigPep-
Yes
modification


PR:000025440 thrombospondin-4 proteolytic cleavage product
THBS4/ClvPrd

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:P49747-1 hCOMP/iso:1 PMID:7670472
GO:0006930 substrate-dependent cell migration, cell extensionPR:000026337 hTHBS4/iso:1/SigPep- PMID:7490284
GO:0007160 cell-matrix adhesionPR:000036494 mTHBS3/iso:1/SigPep- PMID:8468055
GO:0009887 animal organ morphogenesisPR:000036452 hCOMP/iso:1/SigPep- PMID:7713493
PR:P49747-1 hCOMP/iso:1 PMID:7713493

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0080047 pseudoachondroplasiaPR:000000232 hCOMP/var:C387G UniProtKB_VAR:VAR_007625
PR:000000235 hCOMP/var:G440E UniProtKB_VAR:VAR_007628
PR:000000236 hCOMP/var:G440R PMID:9452026
PR:000000238 hCOMP/var:D439V UniProtKB_VAR:VAR_007618
PR:000000239 hCOMP/var:C468Y PMID:7670471; PMID:9452026
PR:000000240 hCOMP/var:D472Y PMID:7670471; PMID:9452026
PR:000000241 hCOMP/var:D473G UniProtKB_VAR:VAR_007635
PR:000000242 hCOMP/var:D290N UniProtKB_VAR:VAR_007614
PR:000000243 hCOMP/var:D482G PMID:9452063
PR:000000244 hCOMP/var:D518N UniProtKB_VAR:VAR_007639
PR:000000245 hCOMP/var:G719D PMID:11746044
PR:000000247 hCOMP/var:T585M PMID:11565064
PR:000000249 hCOMP/var:26 UniProtKB_VAR:VAR_007626
PR:000000250 hCOMP/var:D372del UniProtKB_VAR:VAR_007623
PR:000000251 hCOMP/var:D374del UniProtKB_VAR:VAR_007624
PR:000000252 hCOMP/var:S459del UniProtKB_VAR:VAR_007631
PR:000000253 hCOMP/var:G299R UniProtKB_VAR:VAR_007615
PR:000000254 hCOMP/var:D469del UniProtKB_VAR:VAR_007633
PR:000000255 hCOMP/var:D473del UniProtKB_VAR:VAR_007636
PR:000000257 hCOMP/var:33 UniProtKB_VAR:VAR_007638
PR:000000258 hCOMP/var:C328R UniProtKB_VAR:VAR_007616
PR:000000260 hCOMP/var:C348R PMID:11746045
DO:12721 multiple epiphyseal dysplasiaPR:000000231 hCOMP/var:P276R PMID:11565064
PR:000000233 hCOMP/var:D408Y PMID:9452026
PR:000000234 hCOMP/var:D420A PMID:11565064
PR:000000237 hCOMP/var:N453S UniProtKB_VAR:VAR_007630
PR:000000246 hCOMP/var:N523K PMID:9021009
PR:000000247 hCOMP/var:T585M PMID:11565064
PR:000000248 hCOMP/var:T585R UniProtKB_VAR:VAR_007642
PR:000000256 hCOMP/var:32 UniProtKB_VAR:VAR_007621
PR:000000259 hCOMP/var:D342Y PMID:7670472; PMID:9452026
PR:000000261 hCOMP/var:D361V UniProtKB_VAR:VAR_007619
PR:000000262 hCOMP/var:D361Y PMID:9452026
PR:000000263 hCOMP/var:C371S PMID:9184241

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005201 extracellular matrix structural constituentPR:000036452 hCOMP/iso:1/SigPep- PMID:9749943
GO:0005509 calcium ion bindingPR:000026337 hTHBS4/iso:1/SigPep- PMID:7852353
PR:000036452 hCOMP/iso:1/SigPep- PMID:7670472
PR:000036494 mTHBS3/iso:1/SigPep- PMID:8288588
GO:0008201 heparin bindingPR:000000030 NOG PIRSF:PIRSF002479
PR:000026337 hTHBS4/iso:1/SigPep- PMID:7852353
PR:000036494 mTHBS3/iso:1/SigPep- PMID:8288588
GO:0042802 identical protein bindingPR:000036494 mTHBS3/iso:1/SigPep- PMID:7759526

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036494 mTHBS3/iso:1/SigPep- PMID:8288588
GO:0031012 extracellular matrixPR:000026337 hTHBS4/iso:1/SigPep- PMID:7490284
PR:000036452 hCOMP/iso:1/SigPep- PMID:9749943