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Protein Ontology report - thrombospondin subgroup B

PR:000000030 - http://purl.obolibrary.org/obo/PR_000000030

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000030

PRO name

thrombospondin subgroup B

Definition

"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [PMID:10842357]

PRO Category

family

Parent

PR:000000001 protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Family	1	Organism-Family	0
Gene	3	Organism-Gene	10
Sequence	3	Organism-Sequence	41
Modification	7	Organism-Modification	13

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF002479

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

comp. In Complex?

family

PR:000000030 thrombospondin subgroup B

NOG

Yes

gene

PR:000000085 cartilage oligomeric matrix protein

COMP

organism-gene

PR:P35444 cartilage oligomeric matrix protein (rat)

rCOMP

organism-gene

PR:P49747 cartilage oligomeric matrix protein (human)

hCOMP

organism-sequence

PR:000000231 cartilage oligomeric matrix protein sequence variant P276R (human)

hCOMP/var:P276R

Yes

organism-sequence

PR:000000232 cartilage oligomeric matrix protein sequence variant C387G (human)

hCOMP/var:C387G

Yes

organism-sequence

PR:000000233 cartilage oligomeric matrix protein sequence variant D408Y (human)

hCOMP/var:D408Y

Yes

organism-sequence

PR:000000234 cartilage oligomeric matrix protein sequence variant D420A (human)

hCOMP/var:D420A

Yes

organism-sequence

PR:000000235 cartilage oligomeric matrix protein sequence variant G440E (human)

hCOMP/var:G440E

Yes

organism-sequence

PR:000000236 cartilage oligomeric matrix protein sequence variant G440R (human)

hCOMP/var:G440R

Yes

organism-sequence

PR:000000237 cartilage oligomeric matrix protein sequence variant N453S (human)

hCOMP/var:N453S

Yes

organism-sequence

PR:000000238 cartilage oligomeric matrix protein sequence variant D439V (human)

hCOMP/var:D439V

Yes

organism-sequence

PR:000000239 cartilage oligomeric matrix protein sequence variant C468Y (human)

hCOMP/var:C468Y

Yes

organism-sequence

PR:000000240 cartilage oligomeric matrix protein sequence variant D472Y (human)

hCOMP/var:D472Y

Yes

organism-sequence

PR:000000241 cartilage oligomeric matrix protein sequence variant D473G (human)

hCOMP/var:D473G

Yes

organism-sequence

PR:000000242 cartilage oligomeric matrix protein sequence variant D290N (human)

hCOMP/var:D290N

Yes

organism-sequence

PR:000000243 cartilage oligomeric matrix protein sequence variant D482G (human)

hCOMP/var:D482G

Yes

organism-sequence

PR:000000244 cartilage oligomeric matrix protein sequence variant D518N (human)

hCOMP/var:D518N

Yes

organism-sequence

PR:000000245 cartilage oligomeric matrix protein sequence variant G719D (human)

hCOMP/var:G719D

Yes

organism-sequence

PR:000000246 cartilage oligomeric matrix protein sequence variant N523K (human)

hCOMP/var:N523K

Yes

organism-sequence

PR:000000247 cartilage oligomeric matrix protein sequence variant T585M (human)

hCOMP/var:T585M

Yes

organism-sequence

PR:000000248 cartilage oligomeric matrix protein sequence variant T585R (human)

hCOMP/var:T585R

Yes

organism-sequence

PR:000000249 cartilage oligomeric matrix protein sequence variant 26 (human)

hCOMP/var:26

Yes

organism-sequence

PR:000000250 cartilage oligomeric matrix protein sequence variant D372del (human)

hCOMP/var:D372del

Yes

organism-sequence

PR:000000251 cartilage oligomeric matrix protein sequence variant D374del (human)

hCOMP/var:D374del

Yes

organism-sequence

PR:000000252 cartilage oligomeric matrix protein sequence variant S459del (human)

hCOMP/var:S459del

Yes

organism-sequence

PR:000000253 cartilage oligomeric matrix protein sequence variant G299R (human)

hCOMP/var:G299R

Yes

organism-sequence

PR:000000254 cartilage oligomeric matrix protein sequence variant D469del (human)

hCOMP/var:D469del

Yes

organism-sequence

PR:000000255 cartilage oligomeric matrix protein sequence variant D473del (human)

hCOMP/var:D473del

Yes

organism-sequence

PR:000000256 cartilage oligomeric matrix protein sequence variant 32 (human)

hCOMP/var:32

Yes

organism-sequence

PR:000000257 cartilage oligomeric matrix protein sequence variant 33 (human)

hCOMP/var:33

Yes

organism-sequence

PR:000000258 cartilage oligomeric matrix protein sequence variant C328R (human)

hCOMP/var:C328R

Yes

organism-sequence

PR:000000259 cartilage oligomeric matrix protein sequence variant D342Y (human)

hCOMP/var:D342Y

Yes

organism-sequence

PR:000000260 cartilage oligomeric matrix protein sequence variant C348R (human)

hCOMP/var:C348R

Yes

organism-sequence

PR:000000261 cartilage oligomeric matrix protein sequence variant D361V (human)

hCOMP/var:D361V

Yes

organism-sequence

PR:000000262 cartilage oligomeric matrix protein sequence variant D361Y (human)

hCOMP/var:D361Y

Yes

organism-sequence

PR:000000263 cartilage oligomeric matrix protein sequence variant C371S (human)

hCOMP/var:C371S

Yes

organism-sequence

PR:P49747-1 cartilage oligomeric matrix protein isoform 1 (human)

hCOMP/iso:1

Yes

organism-modification

PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-

Yes

organism-sequence

PR:P49747-2 cartilage oligomeric matrix protein isoform h2 (human)

hCOMP/iso:h2

organism-modification

PR:000056586 cartilage oligomeric matrix protein N-glycosylated 1 (human)

hCOMP/NGlyco:1

organism-modification

PR:000056587 cartilage oligomeric matrix protein N-glycosylated 2 (human)

hCOMP/NGlyco:2

organism-modification

PR:000068189 cartilage oligomeric matrix protein deaminated 1 (human)

hCOMP/Deam:1

organism-modification

PR:000073868 cartilage oligomeric matrix protein deaminated 2 (human)

hCOMP/Deam:2

organism-gene

PR:Q9R0G6 cartilage oligomeric matrix protein (mouse)

mCOMP

organism-sequence

PR:Q9R0G6-1 cartilage oligomeric matrix protein isoform 1 (mouse)

mCOMP/iso:1

sequence

PR:000000230 cartilage oligomeric matrix protein isoform 1

COMP/iso:1

organism-sequence

PR:P49747-1 cartilage oligomeric matrix protein isoform 1 (human)

hCOMP/iso:1

Yes

organism-modification

PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-

Yes

organism-sequence

PR:Q9R0G6-1 cartilage oligomeric matrix protein isoform 1 (mouse)

mCOMP/iso:1

modification

PR:000000540 cartilage oligomeric matrix protein isoform 1, signal peptide removed form

COMP/iso:1/SigPep-

organism-modification

PR:000036452 cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-

Yes

modification

PR:000025416 cartilage oligomeric matrix protein proteolytic cleavage product

COMP/ClvPrd

gene

PR:000000131 thrombospondin-3

THBS3

organism-gene

PR:P49746 thrombospondin-3 (human)

hTHBS3

organism-sequence

PR:P49746-1 thrombospondin-3 isoform 1 (human)

hTHBS3/iso:1

organism-sequence

PR:P49746-2 thrombospondin-3 isoform h2 (human)

hTHBS3/iso:h2

organism-modification

PR:000049438 thrombospondin-3, signal peptide removed form (human)

hTHBS3/SigPep-

organism-modification

PR:000056585 thrombospondin-3 N-glycosylated 1 (human)

hTHBS3/NGlyco:1

organism-gene

PR:Q05895 thrombospondin-3 (mouse)

mTHBS3

organism-sequence

PR:Q05895-1 thrombospondin-3 isoform 1 (mouse)

mTHBS3/iso:1

organism-modification

PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-

Yes

organism-gene

PR:Q8JHW2 thrombospondin-3a (zebrafish)

z-THBS3

sequence

PR:000000378 thrombospondin-3 isoform 1

THBS3/iso:1

organism-sequence

PR:P49746-1 thrombospondin-3 isoform 1 (human)

hTHBS3/iso:1

organism-sequence

PR:Q05895-1 thrombospondin-3 isoform 1 (mouse)

mTHBS3/iso:1

organism-modification

PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-

Yes

modification

PR:000000594 thrombospondin-3 isoform 1, signal peptide removed form

THBS3/iso:1/SigPep-

organism-modification

PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-

Yes

modification

PR:000018284 thrombospondin-3, signal peptide removed form

THBS3/SigPep-

modification

PR:000000594 thrombospondin-3 isoform 1, signal peptide removed form

THBS3/iso:1/SigPep-

organism-modification

PR:000036494 thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-

Yes

organism-modification

PR:000049438 thrombospondin-3, signal peptide removed form (human)

hTHBS3/SigPep-

modification

PR:000025439 thrombospondin-3 proteolytic cleavage product

THBS3/ClvPrd

gene

PR:000000132 thrombospondin-4

THBS4

organism-gene

PR:P35443 thrombospondin-4 (human)

hTHBS4

organism-sequence

PR:P35443-1 thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1

organism-modification

PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-

Yes

organism-modification

PR:000056389 thrombospondin-4 O-glycosylated 1 (human)

hTHBS4/OGlyco:1

organism-modification

PR:000056390 thrombospondin-4 O-glycosylated 2 (human)

hTHBS4/OGlyco:2

organism-modification

PR:000056391 thrombospondin-4 O-glycosylated 3 (human)

hTHBS4/OGlyco:3

organism-modification

PR:000056392 thrombospondin-4 O-glycosylated 4 (human)

hTHBS4/OGlyco:4

organism-gene

PR:P49744 thrombospondin-4 (rat)

rTHBS4

organism-gene

PR:Q8JGW0 thrombospondin-4-B (zebrafish)

z-THBS4

organism-gene

PR:Q9Z1T2 thrombospondin-4 (mouse)

mTHBS4

organism-sequence

PR:Q9Z1T2-1 thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1

sequence

PR:000000379 thrombospondin-4 isoform 1

THBS4/iso:1

organism-sequence

PR:P35443-1 thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1

organism-modification

PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-

Yes

organism-sequence

PR:Q9Z1T2-1 thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1

modification

PR:000000595 thrombospondin-4 isoform 1, signal peptide removed form

THBS4/iso:1/SigPep-

organism-modification

PR:000026337 thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-

Yes

modification

PR:000025440 thrombospondin-4 proteolytic cleavage product

THBS4/ClvPrd

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Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000030 NOG	enables	GO:0008201 heparin binding	PIRSF:PIRSF002479
PR:000000231 hCOMP/var:P276R Example: UniProtKB:P49747-1, Pro-276, CHEBI:29952	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:11565064
PR:000000232 hCOMP/var:C387G Example: UniProtKB:P49747-1, Cys-387, CHEBI:29947	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007625
PR:000000233 hCOMP/var:D408Y Example: UniProtKB:P49747-1, Asp-408, CHEBI:46858	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:9452026
PR:000000234 hCOMP/var:D420A Example: UniProtKB:P49747-1, Asp-420, CHEBI:46217	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:11565064
PR:000000235 hCOMP/var:G440E Example: UniProtKB:P49747-1, Gly-440, CHEBI:29972	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007628
PR:000000236 hCOMP/var:G440R Example: UniProtKB:P49747-1, Gly-440, CHEBI:29952	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:9452026
PR:000000237 hCOMP/var:N453S Example: UniProtKB:P49747-1, Asn-453, CHEBI:29999	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	UniProtKB_VAR:VAR_007630
PR:000000238 hCOMP/var:D439V Example: UniProtKB:P49747-1, Asp-439, CHEBI:30015	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007618
PR:000000239 hCOMP/var:C468Y Example: UniProtKB:P49747-1, Cys-468, CHEBI:46858	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:7670471; PMID:9452026
PR:000000240 hCOMP/var:D472Y Example: UniProtKB:P49747-1, Asp-472, CHEBI:46858	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:7670471; PMID:9452026
PR:000000241 hCOMP/var:D473G Example: UniProtKB:P49747-1, Asp-473, CHEBI:29947	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007635
PR:000000242 hCOMP/var:D290N Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007614
PR:000000243 hCOMP/var:D482G Example: UniProtKB:P49747-1, Asp-482, CHEBI:29947	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:9452063
PR:000000244 hCOMP/var:D518N Example: UniProtKB:P49747-1, Asp-518, CHEBI:50347	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007639
PR:000000245 hCOMP/var:G719D Example: UniProtKB:P49747-1, Gly-719, CHEBI:29958	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:11746044
PR:000000246 hCOMP/var:N523K Example: UniProtKB:P49747-1, Asn-523, CHEBI:29967	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:9021009
PR:000000247 hCOMP/var:T585M Example: UniProtKB:P49747-1, Thr-585, CHEBI:16044	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:11565064
	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:11565064
PR:000000248 hCOMP/var:T585R Example: UniProtKB:P49747-1, Thr-585, CHEBI:29952	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	UniProtKB_VAR:VAR_007642
PR:000000249 hCOMP/var:26	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007626
PR:000000250 hCOMP/var:D372del Example: UniProtKB:P49747-1, 21-371, 373-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007623
PR:000000251 hCOMP/var:D374del Example: UniProtKB:P49747-1, 21-373, 375-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007624
PR:000000252 hCOMP/var:S459del Example: UniProtKB:P49747-1, 21-458, 460-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007631
PR:000000253 hCOMP/var:G299R Example: UniProtKB:P49747-1, Gly-299, CHEBI:29952	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007615
PR:000000254 hCOMP/var:D469del Example: UniProtKB:P49747-1, 21-468, 470-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007633
PR:000000255 hCOMP/var:D473del Example: UniProtKB:P49747-1, 21-472, 474-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007636
PR:000000256 hCOMP/var:32 Example: UniProtKB:P49747-1, 21-366, 369-757	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	UniProtKB_VAR:VAR_007621
PR:000000257 hCOMP/var:33 Example: UniProtKB:P49747-1, 21-512, 517-757	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007638
PR:000000258 hCOMP/var:C328R Example: UniProtKB:P49747-1, Cys-328, CHEBI:29952	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	UniProtKB_VAR:VAR_007616
PR:000000259 hCOMP/var:D342Y Example: UniProtKB:P49747-1, Asp-342, CHEBI:46858	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:7670472; PMID:9452026
PR:000000260 hCOMP/var:C348R Example: UniProtKB:P49747-1, Cys-348, CHEBI:29952	associated_with_disease_progression	DO:0080047 pseudoachondroplasia	PMID:11746045
PR:000000261 hCOMP/var:D361V Example: UniProtKB:P49747-1, Asp-361, CHEBI:30015	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	UniProtKB_VAR:VAR_007619
PR:000000262 hCOMP/var:D361Y Example: UniProtKB:P49747-1, Asp-361, CHEBI:46858	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:9452026
PR:000000263 hCOMP/var:C371S Example: UniProtKB:P49747-1, Cys-371, CHEBI:29999	associated_with_disease_progression	DO:12721 multiple epiphyseal dysplasia	PMID:9184241
PR:000026337 hTHBS4/iso:1/SigPep- UniProtKB:P35443-1, 27-961	acts_upstream_of_or_within	GO:0006930 substrate-dependent cell migration, cell extension	PMID:7490284
	enables	GO:0005509 calcium ion binding	PMID:7852353
	enables	GO:0008201 heparin binding	PMID:7852353
	located_in	GO:0031012 extracellular matrix	PMID:7490284
PR:000036452 hCOMP/iso:1/SigPep- UniProtKB:P49747-1, 21-757	acts_upstream_of_or_within	GO:0009887 animal organ morphogenesis	PMID:7713493
	enables	GO:0005201 extracellular matrix structural constituent	PMID:9749943
	enables	GO:0005509 calcium ion binding	PMID:7670472
	located_in	GO:0031012 extracellular matrix	PMID:9749943
PR:000036494 mTHBS3/iso:1/SigPep- UniProtKB:Q05895-1, 22-956	acts_upstream_of_or_within	GO:0007160 cell-matrix adhesion	PMID:8468055
	enables	GO:0005509 calcium ion binding	PMID:8288588
		GO:0008201 heparin binding	PMID:8288588
		GO:0042802 identical protein binding	PMID:7759526
	located_in	GO:0005615 extracellular space	PMID:8288588
PR:P49747-1 hCOMP/iso:1	acts_upstream_of_or_within	GO:0001501 skeletal system development	PMID:7670472
PR:P49747-1 hCOMP/iso:1	acts_upstream_of_or_within	GO:0009887 animal organ morphogenesis	PMID:7713493