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Protein Ontology report - thrombospondin subgroup B
PR:000000030 - http://purl.obolibrary.org/obo/PR_000000030
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000030   
  PRO namethrombospondin subgroup B 
  Definition"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [PMID:10842357
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 10                                        
         Sequence3                                                  Organism-Sequence 41                                        
         Modification7                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF002479
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
family



PR:000000030

thrombospondin subgroup B

NOG


"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [PMID:10842357]

Yes

gene



PR:000000085

cartilage oligomeric matrix protein

COMP


"A thrombospondin subgroup B that is a translation product of the human COMP gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35444

cartilage oligomeric matrix protein (rat)

rCOMP


"A cartilage oligomeric matrix protein that is encoded in the genome of rat." [OMA:P35444, PRO:DNx]


organism-gene



PR:P49747

cartilage oligomeric matrix protein (human)

hCOMP


"A cartilage oligomeric matrix protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49747]


organism-sequence



PR:000000231

cartilage oligomeric matrix protein sequence variant P276R (human)

hCOMP/var:P276R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Pro-276 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Pro-276, CHEBI:29952." [PMID:11565064, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000232

cartilage oligomeric matrix protein sequence variant C387G (human)

hCOMP/var:C387G


"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Cys-387 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-387, CHEBI:29947." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000233

cartilage oligomeric matrix protein sequence variant D408Y (human)

hCOMP/var:D408Y


"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-408 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-408, CHEBI:46858." [PMID:9452026, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000234

cartilage oligomeric matrix protein sequence variant D420A (human)

hCOMP/var:D420A


"A cartilage oligomeric matrix protein (human) that has an Ala residue at the position equivalent to Asp-420 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-420, CHEBI:46217." [PMID:11565064, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000235

cartilage oligomeric matrix protein sequence variant G440E (human)

hCOMP/var:G440E


"A cartilage oligomeric matrix protein (human) that has a Glu residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29972." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000236

cartilage oligomeric matrix protein sequence variant G440R (human)

hCOMP/var:G440R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29952." [PMID:9452026, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000237

cartilage oligomeric matrix protein sequence variant N453S (human)

hCOMP/var:N453S


"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Asn-453 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-453, CHEBI:29999." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000238

cartilage oligomeric matrix protein sequence variant D439V (human)

hCOMP/var:D439V


"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-439 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-439, CHEBI:30015." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000239

cartilage oligomeric matrix protein sequence variant C468Y (human)

hCOMP/var:C468Y


"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Cys-468 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-468, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000240

cartilage oligomeric matrix protein sequence variant D472Y (human)

hCOMP/var:D472Y


"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-472 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-472, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000241

cartilage oligomeric matrix protein sequence variant D473G (human)

hCOMP/var:D473G


"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-473, CHEBI:29947." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000242

cartilage oligomeric matrix protein sequence variant D290N (human)

hCOMP/var:D290N


"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-290 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000243

cartilage oligomeric matrix protein sequence variant D482G (human)

hCOMP/var:D482G


"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-482 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-482, CHEBI:29947." [PMID:9452063, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000244

cartilage oligomeric matrix protein sequence variant D518N (human)

hCOMP/var:D518N


"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-518 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-518, CHEBI:50347." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000245

cartilage oligomeric matrix protein sequence variant G719D (human)

hCOMP/var:G719D


"A cartilage oligomeric matrix protein (human) that has an Asp residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-719, CHEBI:29958." [PMID:11746044, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000246

cartilage oligomeric matrix protein sequence variant N523K (human)

hCOMP/var:N523K


"A cartilage oligomeric matrix protein (human) that has a Lys residue at the position equivalent to Asn-523 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-523, CHEBI:29967." [PMID:9021009, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000247

cartilage oligomeric matrix protein sequence variant T585M (human)

hCOMP/var:T585M


"A cartilage oligomeric matrix protein (human) that has a Met residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:16044." [PMID:11565064, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000248

cartilage oligomeric matrix protein sequence variant T585R (human)

hCOMP/var:T585R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000249

cartilage oligomeric matrix protein sequence variant 26 (human)

hCOMP/var:26


"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to region 391-394 of the amino acid sequence represented by UniProtKB:P49747-1." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000250

cartilage oligomeric matrix protein sequence variant D372del (human)

hCOMP/var:D372del


"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-372 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-371, 373-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000251

cartilage oligomeric matrix protein sequence variant D374del (human)

hCOMP/var:D374del


"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-374 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-373, 375-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000252

cartilage oligomeric matrix protein sequence variant S459del (human)

hCOMP/var:S459del


"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Ser-459 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-458, 460-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000253

cartilage oligomeric matrix protein sequence variant G299R (human)

hCOMP/var:G299R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-299 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-299, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000254

cartilage oligomeric matrix protein sequence variant D469del (human)

hCOMP/var:D469del


"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-469 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-468, 470-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000255

cartilage oligomeric matrix protein sequence variant D473del (human)

hCOMP/var:D473del


"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-472, 474-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000256

cartilage oligomeric matrix protein sequence variant 32 (human)

hCOMP/var:32


"A cartilage oligomeric matrix protein (human) that has a two-residue deletion at the positions equivalent to region 367-368 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-366, 369-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000257

cartilage oligomeric matrix protein sequence variant 33 (human)

hCOMP/var:33


"A cartilage oligomeric matrix protein (human) that has a four-residue deletion at the positions equivalent to region 513-516 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-512, 517-757." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000258

cartilage oligomeric matrix protein sequence variant C328R (human)

hCOMP/var:C328R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-328 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-328, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000259

cartilage oligomeric matrix protein sequence variant D342Y (human)

hCOMP/var:D342Y


"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-342 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-342, CHEBI:46858." [PMID:7670472, PMID:9452026, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000260

cartilage oligomeric matrix protein sequence variant C348R (human)

hCOMP/var:C348R


"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-348 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-348, CHEBI:29952." [PMID:11746045, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000261

cartilage oligomeric matrix protein sequence variant D361V (human)

hCOMP/var:D361V


"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:30015." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000262

cartilage oligomeric matrix protein sequence variant D361Y (human)

hCOMP/var:D361Y


"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:46858." [PMID:9452027, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000263

cartilage oligomeric matrix protein sequence variant C371S (human)

hCOMP/var:C371S


"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Cys-371 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-371, CHEBI:29999." [PMID:9184241, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P49747-1

cartilage oligomeric matrix protein isoform 1 (human)

hCOMP/iso:1


"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036452

cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-


"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]

Yes

organism-sequence



PR:P49747-2

cartilage oligomeric matrix protein isoform h2 (human)

hCOMP/iso:h2


"A cartilage oligomeric matrix protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49747-2." [PRO:DNx, UniProtKB:P49747]


organism-modification



PR:000056586

cartilage oligomeric matrix protein N-glycosylated 1 (human)

hCOMP/NGlyco:1


"A cartilage oligomeric matrix protein (human) that has been N-glycosylated at the residue equivalent to Asn-121 of the amino acid sequence represented by UniProtKB:P49747-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P49747-1, Asn-121, MOD:00160~GNO:G83555HU." [GlyGen:P49747-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000056587

cartilage oligomeric matrix protein N-glycosylated 2 (human)

hCOMP/NGlyco:2


"A cartilage oligomeric matrix protein (human) that has been N-glycosylated at the residue equivalent to Asn-742 of the amino acid sequence represented by UniProtKB:P49747-1, in which the glycan composition is represented by GlyTouCan:G80920RR. Example: UniProtKB:P49747-1, Asn-742, MOD:00160~GNO:G80920RR." [GlyGen:P49747-1, PMID:29671580, PRO:DNx]


organism-modification



PR:000068189

cartilage oligomeric matrix protein deaminated 1 (human)

hCOMP/Deam:1


"A cartilage oligomeric matrix protein (human) that has been deaminated on the residue at the position equivalent to Asn-123 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-123, MOD:00684." [IEDB_epitope:167687, PRO:DNx]


organism-modification



PR:000073868

cartilage oligomeric matrix protein deaminated 2 (human)

hCOMP/Deam:2


"A cartilage oligomeric matrix protein (human) that has been deaminated on the residue at the position equivalent to Asn-78 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-78, MOD:00684." [IEDB_epitope:167500, PRO:DNx]


organism-gene



PR:Q9R0G6

cartilage oligomeric matrix protein (mouse)

mCOMP


"A cartilage oligomeric matrix protein that is encoded in the genome of mouse." [OMA:Q9R0G6, PRO:DNx]


organism-sequence



PR:Q9R0G6-1

cartilage oligomeric matrix protein isoform 1 (mouse)

mCOMP/iso:1


"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000230

cartilage oligomeric matrix protein isoform 1

COMP/iso:1


"A cartilage oligomeric matrix protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49747-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P49747-1

cartilage oligomeric matrix protein isoform 1 (human)

hCOMP/iso:1


"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036452

cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-


"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]

Yes

organism-sequence



PR:Q9R0G6-1

cartilage oligomeric matrix protein isoform 1 (mouse)

mCOMP/iso:1


"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000540

cartilage oligomeric matrix protein isoform 1, signal peptide removed form

COMP/iso:1/SigPep-


"A cartilage oligomeric matrix protein isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:CNA]


organism-modification



PR:000036452

cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human)

hCOMP/iso:1/SigPep-


"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]

Yes

modification



PR:000025416

cartilage oligomeric matrix protein proteolytic cleavage product

COMP/ClvPrd


"A cartilage oligomeric matrix protein that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000000131

thrombospondin-3

THBS3


"A thrombospondin subgroup B that is a translation product of the human THBS3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P49746

thrombospondin-3 (human)

hTHBS3


"A thrombospondin-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P49746]


organism-sequence



PR:P49746-1

thrombospondin-3 isoform 1 (human)

hTHBS3/iso:1


"A thrombospondin-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P49746-2

thrombospondin-3 isoform h2 (human)

hTHBS3/iso:h2


"A thrombospondin-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49746-2." [PRO:DNx, UniProtKB:P49746]


organism-modification



PR:000049438

thrombospondin-3, signal peptide removed form (human)

hTHBS3/SigPep-


"A thrombospondin-3 (human) that has had the signal peptide removed. UniProtKB:P49746, 23-956." [PRO:DNx, Reactome:R-HSA-66522]


organism-modification



PR:000056585

thrombospondin-3 N-glycosylated 1 (human)

hTHBS3/NGlyco:1


"A thrombospondin-3 (human) that has been N-glycosylated at the residue equivalent to Asn-407 of the amino acid sequence represented by UniProtKB:P49746-1, in which the glycan composition is represented by GlyTouCan:G87051GH. Example: UniProtKB:P49746-1, Asn-407, MOD:00160~GNO:G87051GH." [GlyGen:P49746-1, PMID:29741879, PRO:DNx]


organism-gene



PR:Q05895

thrombospondin-3 (mouse)

mTHBS3


"A thrombospondin-3 that is encoded in the genome of mouse." [OMA:Q05895, PRO:DNx]


organism-sequence



PR:Q05895-1

thrombospondin-3 isoform 1 (mouse)

mTHBS3/iso:1


"A thrombospondin-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036494

thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1, signal peptide removed form in mouse. UniProtKB:Q05895-1, 22-956." [PMID:7759526, PMID:8288588, PMID:8468055, PRO:CNA]

Yes

organism-gene



PR:Q8JHW2

thrombospondin-3a (zebrafish)

z-THBS3


"A thrombospondin-3 that is encoded in the genome of zebrafish." [PRO:CNA]


sequence



PR:000000378

thrombospondin-3 isoform 1

THBS3/iso:1


"A thrombospondin-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49746-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P49746-1

thrombospondin-3 isoform 1 (human)

hTHBS3/iso:1


"A thrombospondin-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q05895-1

thrombospondin-3 isoform 1 (mouse)

mTHBS3/iso:1


"A thrombospondin-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036494

thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1, signal peptide removed form in mouse. UniProtKB:Q05895-1, 22-956." [PMID:7759526, PMID:8288588, PMID:8468055, PRO:CNA]

Yes

modification



PR:000000594

thrombospondin-3 isoform 1, signal peptide removed form

THBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1 that has had the signal peptide removed to yield the mature protein." [PMID:8654563]


organism-modification



PR:000036494

thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1, signal peptide removed form in mouse. UniProtKB:Q05895-1, 22-956." [PMID:7759526, PMID:8288588, PMID:8468055, PRO:CNA]

Yes

modification



PR:000018284

thrombospondin-3, signal peptide removed form

THBS3/SigPep-


"A thrombospondin-3 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000594

thrombospondin-3 isoform 1, signal peptide removed form

THBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1 that has had the signal peptide removed to yield the mature protein." [PMID:8654563]


organism-modification



PR:000036494

thrombospondin-3 isoform 1, signal peptide removed form (mouse)

mTHBS3/iso:1/SigPep-


"A thrombospondin-3 isoform 1, signal peptide removed form in mouse. UniProtKB:Q05895-1, 22-956." [PMID:7759526, PMID:8288588, PMID:8468055, PRO:CNA]

Yes

organism-modification



PR:000049438

thrombospondin-3, signal peptide removed form (human)

hTHBS3/SigPep-


"A thrombospondin-3 (human) that has had the signal peptide removed. UniProtKB:P49746, 23-956." [PRO:DNx, Reactome:R-HSA-66522]


modification



PR:000025439

thrombospondin-3 proteolytic cleavage product

THBS3/ClvPrd


"A thrombospondin-3 that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000000132

thrombospondin-4

THBS4


"A thrombospondin subgroup B that is a translation product of the human THBS4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35443

thrombospondin-4 (human)

hTHBS4


"A thrombospondin-4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35443]


organism-sequence



PR:P35443-1

thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

organism-modification



PR:000056389

thrombospondin-4 O-glycosylated 1 (human)

hTHBS4/OGlyco:1


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Ser-272 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P35443-1, Ser-272, MOD:00002~GNO:G53434XO." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056390

thrombospondin-4 O-glycosylated 2 (human)

hTHBS4/OGlyco:2


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-270 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P35443-1, Thr-270, MOD:00005~GNO:G43417UB." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056391

thrombospondin-4 O-glycosylated 3 (human)

hTHBS4/OGlyco:3


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-273 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P35443-1, Thr-273, MOD:00005~GNO:G29068FM." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056392

thrombospondin-4 O-glycosylated 4 (human)

hTHBS4/OGlyco:4


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-273 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P35443-1, Thr-273, MOD:00005~GNO:G43417UB." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P49744

thrombospondin-4 (rat)

rTHBS4


"A thrombospondin-4 that is encoded in the genome of rat." [OMA:P49744, PRO:DNx]


organism-gene



PR:Q8JGW0

thrombospondin-4-B (zebrafish)

z-THBS4


"A thrombospondin-4 that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q9Z1T2

thrombospondin-4 (mouse)

mTHBS4


"A thrombospondin-4 that is encoded in the genome of mouse." [OMA:Q9Z1T2, PRO:DNx]


organism-sequence



PR:Q9Z1T2-1

thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000379

thrombospondin-4 isoform 1

THBS4/iso:1


"A thrombospondin-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35443-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P35443-1

thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

organism-sequence



PR:Q9Z1T2-1

thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000595

thrombospondin-4 isoform 1, signal peptide removed form

THBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1 that has had the signal peptide removed to yield the mature protein." [PMID:8654563]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

modification



PR:000025440

thrombospondin-4 proteolytic cleavage product

THBS4/ClvPrd


"A thrombospondin-4 that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000030 NOG enablesGO:0008201 heparin binding PIRSF:PIRSF002479
PR:000000231 hCOMP/var:P276R
Example: UniProtKB:P49747-1, Pro-276, CHEBI:29952
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000232 hCOMP/var:C387G
Example: UniProtKB:P49747-1, Cys-387, CHEBI:29947
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007625
PR:000000233 hCOMP/var:D408Y
Example: UniProtKB:P49747-1, Asp-408, CHEBI:46858
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9452026
PR:000000234 hCOMP/var:D420A
Example: UniProtKB:P49747-1, Asp-420, CHEBI:46217
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000235 hCOMP/var:G440E
Example: UniProtKB:P49747-1, Gly-440, CHEBI:29972
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007628
PR:000000236 hCOMP/var:G440R
Example: UniProtKB:P49747-1, Gly-440, CHEBI:29952
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:9452026
PR:000000237 hCOMP/var:N453S
Example: UniProtKB:P49747-1, Asn-453, CHEBI:29999
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007630
PR:000000238 hCOMP/var:D439V
Example: UniProtKB:P49747-1, Asp-439, CHEBI:30015
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007618
PR:000000239 hCOMP/var:C468Y
Example: UniProtKB:P49747-1, Cys-468, CHEBI:46858
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:7670471; PMID:9452026
PR:000000240 hCOMP/var:D472Y
Example: UniProtKB:P49747-1, Asp-472, CHEBI:46858
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:7670471; PMID:9452026
PR:000000241 hCOMP/var:D473G
Example: UniProtKB:P49747-1, Asp-473, CHEBI:29947
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007635
PR:000000242 hCOMP/var:D290N
Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007614
PR:000000243 hCOMP/var:D482G
Example: UniProtKB:P49747-1, Asp-482, CHEBI:29947
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:9452063
PR:000000244 hCOMP/var:D518N
Example: UniProtKB:P49747-1, Asp-518, CHEBI:50347
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007639
PR:000000245 hCOMP/var:G719D
Example: UniProtKB:P49747-1, Gly-719, CHEBI:29958
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11746044
PR:000000246 hCOMP/var:N523K
Example: UniProtKB:P49747-1, Asn-523, CHEBI:29967
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9021009
PR:000000247 hCOMP/var:T585M
Example: UniProtKB:P49747-1, Thr-585, CHEBI:16044
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11565064
DO:12721 multiple epiphyseal dysplasia PMID:11565064
PR:000000248 hCOMP/var:T585R
Example: UniProtKB:P49747-1, Thr-585, CHEBI:29952
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007642
PR:000000249 hCOMP/var:26 associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007626
PR:000000250 hCOMP/var:D372del
Example: UniProtKB:P49747-1, 21-371, 373-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007623
PR:000000251 hCOMP/var:D374del
Example: UniProtKB:P49747-1, 21-373, 375-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007624
PR:000000252 hCOMP/var:S459del
Example: UniProtKB:P49747-1, 21-458, 460-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007631
PR:000000253 hCOMP/var:G299R
Example: UniProtKB:P49747-1, Gly-299, CHEBI:29952
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007615
PR:000000254 hCOMP/var:D469del
Example: UniProtKB:P49747-1, 21-468, 470-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007633
PR:000000255 hCOMP/var:D473del
Example: UniProtKB:P49747-1, 21-472, 474-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007636
PR:000000256 hCOMP/var:32
Example: UniProtKB:P49747-1, 21-366, 369-757
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007621
PR:000000257 hCOMP/var:33
Example: UniProtKB:P49747-1, 21-512, 517-757
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007638
PR:000000258 hCOMP/var:C328R
Example: UniProtKB:P49747-1, Cys-328, CHEBI:29952
associated_with_disease_progressionDO:0080047 pseudoachondroplasia UniProtKB_VAR:VAR_007616
PR:000000259 hCOMP/var:D342Y
Example: UniProtKB:P49747-1, Asp-342, CHEBI:46858
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:7670472; PMID:9452026
PR:000000260 hCOMP/var:C348R
Example: UniProtKB:P49747-1, Cys-348, CHEBI:29952
associated_with_disease_progressionDO:0080047 pseudoachondroplasia PMID:11746045
PR:000000261 hCOMP/var:D361V
Example: UniProtKB:P49747-1, Asp-361, CHEBI:30015
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia UniProtKB_VAR:VAR_007619
PR:000000262 hCOMP/var:D361Y
Example: UniProtKB:P49747-1, Asp-361, CHEBI:46858
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9452026
PR:000000263 hCOMP/var:C371S
Example: UniProtKB:P49747-1, Cys-371, CHEBI:29999
associated_with_disease_progressionDO:12721 multiple epiphyseal dysplasia PMID:9184241
PR:000026337 hTHBS4/iso:1/SigPep-
UniProtKB:P35443-1, 27-961
acts_upstream_of_or_withinGO:0006930 substrate-dependent cell migration, cell extension PMID:7490284
enablesGO:0005509 calcium ion binding PMID:7852353
GO:0008201 heparin binding PMID:7852353
located_inGO:0031012 extracellular matrix PMID:7490284
PR:000036452 hCOMP/iso:1/SigPep-
UniProtKB:P49747-1, 21-757
acts_upstream_of_or_withinGO:0009887 animal organ morphogenesis PMID:7713493
enablesGO:0005201 extracellular matrix structural constituent PMID:9749943
GO:0005509 calcium ion binding PMID:7670472
located_inGO:0031012 extracellular matrix PMID:9749943
PR:000036494 mTHBS3/iso:1/SigPep-
UniProtKB:Q05895-1, 22-956
acts_upstream_of_or_withinGO:0007160 cell-matrix adhesion PMID:8468055
enablesGO:0005509 calcium ion binding PMID:8288588
GO:0008201 heparin binding PMID:8288588
GO:0042802 identical protein binding PMID:7759526
located_inGO:0005615 extracellular space PMID:8288588
PR:P49747-1 hCOMP/iso:1 acts_upstream_of_or_withinGO:0001501 skeletal system development PMID:7670472
GO:0009887 animal organ morphogenesis PMID:7713493