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Protein Ontology report - transcription adapter with TAZ, KIX and bromo-domains
PR:000000031 - http://purl.obolibrary.org/obo/PR_000000031
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000031   
  PRO nametranscription adapter with TAZ, KIX and bromo-domains 
  Synonyms
PRO-Short-label: EXACT:fam:CBP-p300
  Definition"A protein that has a core domain composition consisting of a TAZ zinc finger (Pfam:PF02135) domain, a KIX domain (Pfam:PF02172), a Bromodomain (Pfam:PF00439), a dystrophin zinc finger domain, and a second copy of the TAZ zinc finger (Pfam:PF02135) domain." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 2                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification5                                                  Organism-Modification 12                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036333
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000031 transcription adapter with TAZ, KIX and bromo-domains
fam:CBP-p300
Yes
gene


PR:000000090 CREB-binding protein
CREBBP

organism-gene


PR:P45481 histone lysine acetyltransferase CREBBP (mouse)
mCREBBP

organism-sequence


PR:P45481-1 CREB-binding protein isoform 1 (mouse)
mCREBBP/iso:1
Yes
organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
organism-modification


PR:000077765 histone lysine acetyltransferase CREBBP cysteinylated 1 (mouse)
mCREBBP/Cyst:1

organism-gene


PR:Q6JHU9 histone lysine acetyltransferase CREBBP (rat)
rCREBBP

organism-gene


PR:Q92793 CREB-binding protein (human)
hCREBBP

organism-sequence


PR:000000266 CREB-binding protein sequence variant R1378P (human)
hCREBBP/var:R1378P
Yes
organism-sequence


PR:Q92793-1 CREB-binding protein isoform 1 (human)
hCREBBP/iso:1
Yes
organism-sequence


PR:Q92793-2 CREB-binding protein isoform h2 (human)
hCREBBP/iso:h2

organism-modification


PR:000064816 CREB-binding protein sumoylated 1 (human)
hCREBBP/Sumo:1

organism-modification


PR:000067783 CREB-binding protein phosphorylated 1 (human)
hCREBBP/Phos:1

organism-modification


PR:000080126 CREB-binding protein phosphorylated 2 (human)
hCREBBP/Phos:2

sequence


PR:000000265 CREB-binding protein isoform 1
CREBBP/iso:1

organism-sequence


PR:P45481-1 CREB-binding protein isoform 1 (mouse)
mCREBBP/iso:1
Yes
organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
organism-sequence


PR:Q92793-1 CREB-binding protein isoform 1 (human)
hCREBBP/iso:1
Yes
modification


PR:000000426 CREB-binding protein isoform 1 methylated form
CREBBP/iso:1/MeRes+

modification


PR:000000541 CREB-binding protein isoform 1 methylated 1
CREBBP/iso:1/Me:1

organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
modification


PR:000026573 CREB-binding protein isoform 1, initiator methionine removed form
CREBBP/iso:1/InitMet-

modification


PR:000018275 CREB-binding protein, initiator methionine removed form
CREBBP/InitMet-

modification


PR:000026573 CREB-binding protein isoform 1, initiator methionine removed form
CREBBP/iso:1/InitMet-

gene


PR:000007102 histone acetyltransferase p300
EP300

organism-gene


PR:B2RWS6 histone acetyltransferase p300 (mouse)
mEP300

organism-gene


PR:Q09472 histone acetyltransferase p300 (human)
hEP300

organism-modification


PR:000045891 histone acetyltransferase p300 phosphorylated 1 (human)
hEP300/Phos:1

organism-modification


PR:000047286 histone acetyltransferase p300, initiator methionine removed form (human)
hEP300/InitMet-

organism-modification


PR:000063801 histone acetyltransferase p300, initiator methionine removed phosphoserine and phosphothreonine form (human)
hEP300/InitMet-/pSerThr+

organism-modification


PR:000064677 histone acetyltransferase p300, initiator methionine removed sumoylated 1 (human)
hEP300/InitMet-/Sumo:1

organism-modification


PR:000071223 histone acetyltransferase p300 deaminated 1 (human)
hEP300/Deam:1

organism-modification


PR:000076688 histone acetyltransferase p300 deaminated 2 (human)
hEP300/Deam:2

organism-modification


PR:000083894 histone acetyltransferase p300 deaminated 3 (human)
hEP300/Deam:3

modification


PR:000019786 histone acetyltransferase p300, initiator methionine removed form
EP300/InitMet-

organism-modification


PR:000047286 histone acetyltransferase p300, initiator methionine removed form (human)
hEP300/InitMet-

organism-family


PR:000027108 transcription adapter with TAZ, KIX and bromo-domains (human)
h(CBP-p300)

Yes




PR:Q09472 histone acetyltransferase p300 (human)





PR:Q92793 CREB-binding protein (human)

organism-family


PR:000027109 transcription adapter with TAZ, KIX and bromo-domains (mouse)
m(CBP-p300)





PR:B2RWS6 histone acetyltransferase p300 (mouse)





PR:P45481 histone lysine acetyltransferase CREBBP (mouse)

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fam:CBP-p300 forms found in complexes   

fam:CBP-p300 Component
 Complexes
PR:000027108 h(CBP-p300) PR:000027111 double-stranded RNA-activated factor 1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000031 fam:CBP-p300 enablesGO:0004402 histone acetyltransferase activity PANTHER:PTHR13808; PIRSF:PIRSF036333
PR:000000266 hCREBBP/var:R1378P
Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342		 associated_with_disease_progressionDO:1933 Rubinstein-Taybi syndrome PMID:11331617
enablesNOT GO:0004402 histone acetyltransferase activity PMID:11331617
located_inSO:0001559 polypeptide_loss_of_function_variant PMID:11331617
PR:000036453 mCREBBP/iso:1/Me:1
UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658		 located_inNOT GO:0000123 histone acetyltransferase complex PMID:11701890
GO:0005634 nucleus PMID:11701890
PR:P45481-1 mCREBBP/iso:1 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:15464984
enablesGO:0004402 histone acetyltransferase activity PMID:11867645
GO:0005515 protein binding with PR:P88946 orfK9 (tax435895) PMID:12496368
GO:0005515 protein binding with PR:Q60749 GAP-associated tyrosine phosphoprotein p62 (mouse) PMID:12496368
GO:0005515 protein binding PMID:12496368
GO:0016407 acetyltransferase activity PMID:12496368
located_inGO:0005634 nucleus PMID:11963968; PMID:12496368
PR:Q92793-1 hCREBBP/iso:1 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12169688; PMID:7913207
GO:0045893 positive regulation of DNA-templated transcription PMID:11742995
enablesGO:0003713 transcription coactivator activity PMID:10733899; PMID:10893273; PMID:12169688; PMID:12586840; PMID:8684459
GO:0004402 histone acetyltransferase activity PMID:11742995
GO:0005515 protein binding with PR:P42858 HD PMID:11799127
GO:0005515 protein binding with PR:P55209 hNAP1L1 PMID:11799127
GO:0005515 protein binding with PR:Q04206 hRELA PMID:11799127
GO:0005515 protein binding with PR:Q14686 activating signal cointegrator 2 (human) PMID:11799127
GO:0005515 protein binding with PR:Q16665 ARNT-interacting protein (human) PMID:11799127
GO:0005515 protein binding with PR:Q92793 CBP PMID:11799127
GO:0005515 protein binding with PR:Q99967-1 PMID:11799127
GO:0005515 protein binding with PR:Q9UER7 BING2 PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0016407 acetyltransferase activity PMID:11742995
located_inGO:0000123 histone acetyltransferase complex PMID:9742083
GO:0005634 nucleus PMID:7913207