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Protein Ontology report - tumor necrosis factor, TNF-like
PR:000000033 - http://purl.obolibrary.org/obo/PR_000000033
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000033   
  PRO nametumor necrosis factor, TNF-like 
  Definition"A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229)." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 17                                        
         Sequence12                                                  Organism-Sequence 20                                        
         Modification15                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001873
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000033 tumor necrosis factor, TNF-like
fam:CBP-p300
Yes
gene


PR:000000095 tumor necrosis factor ligand superfamily member 6
FASLG
Yes
organism-gene


PR:P36940 tumor necrosis factor ligand superfamily member 6 (rat)
rFASLG

organism-gene


PR:P41047 tumor necrosis factor ligand superfamily member 6 (mouse)
mFASLG

organism-sequence


PR:P41047-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)
mFASLG/iso:FasL
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P41047-2 tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)
mFASLG/iso:FasLS
Yes
organism-gene


PR:P48023 tumor necrosis factor ligand superfamily member 6 (human)
hFASLG

organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
organism-sequence


PR:P48023-2 tumor necrosis factor ligand superfamily member 6 isoform h2 (human)
hFASLG/iso:h2

sequence


PR:000000276 tumor necrosis factor ligand superfamily member 6 isoform FasL
FASLG/iso:FasL

sequence


PR:000000278 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L
FASLG/iso:FasL/var:F273L

organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P41047-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)
mFASLG/iso:FasL
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
modification


PR:000000432 tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form
FASLG/iso:FasL/GlycoRes+

modification


PR:000000546 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1
FASLG/iso:FasL/NGlyco:1

organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
modification


PR:000000547 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form
FASLG/iso:FasL/Clv:soluble

organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
sequence


PR:000000277 tumor necrosis factor ligand superfamily member 6 isoform FasLS
FASLG/iso:FasLS

organism-sequence


PR:P41047-2 tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)
mFASLG/iso:FasLS
Yes
modification


PR:000018277 tumor necrosis factor ligand superfamily member 6 proteolytic cleavage product
FASLG/ClvPrd

modification


PR:000000547 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form
FASLG/iso:FasL/Clv:soluble

organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
gene


PR:000000134 tumor necrosis factor
TNF

organism-gene


PR:P01375 tumor necrosis factor (human)
hTNF

Yes
organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-modification


PR:000051774 tumor necrosis factor O-glycosylated 1 (human)
hTNF/OGlyco:1

organism-modification


PR:000051775 tumor necrosis factor O-glycosylated 2 (human)
hTNF/OGlyco:2

organism-gene


PR:P06804 tumor necrosis factor (mouse)
mTNF

organism-sequence


PR:P06804-1 tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1

organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
organism-gene


PR:P16599 tumor necrosis factor (rat)
rTNF

sequence


PR:000000381 tumor necrosis factor isoform 1
TNF/iso:1

organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-sequence


PR:P06804-1 tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1

organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
modification


PR:000000496 tumor necrosis factor isoform 1 myristoylated form
TNF/iso:1/MyrRes+

modification


PR:000000606 tumor necrosis factor isoform 1 myristoylated 1
TNF/iso:1/Myr:1

organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
modification


PR:000000497 tumor necrosis factor isoform 1 phosphorylated form
TNF/iso:1/PhosRes+

modification


PR:000000607 tumor necrosis factor isoform 1 phosphorylated 1
TNF/iso:1/Phos:1

organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
modification


PR:000000604 tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1

organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
modification


PR:000000605 tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2

organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
modification


PR:000018285 tumor necrosis factor proteolytic cleavage product
TNF/ClvPrd

modification


PR:000000604 tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1

organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
modification


PR:000000605 tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2

organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
gene


PR:000002222 tumor necrosis factor ligand superfamily member 14
TNFSF14

organism-gene


PR:O43557 tumor necrosis factor ligand superfamily member 14 (human)
hTNFSF14

organism-sequence


PR:O43557-1 tumor necrosis factor ligand superfamily member 14 isoform 1 (human)
hTNFSF14/iso:1

organism-sequence


PR:O43557-2 tumor necrosis factor ligand superfamily member 14 isoform 2 (human)
hTNFSF14/iso:2

organism-modification


PR:000065924 tumor necrosis factor ligand superfamily member 14 deaminated 1 (human)
hTNFSF14/Deam:1

organism-modification


PR:000082240 tumor necrosis factor ligand superfamily member 14 phosphorylated 1 (human)
hTNFSF14/Phos:1

organism-gene


PR:Q9QYH9 tumor necrosis factor ligand superfamily member 14 (mouse)
mTNFSF14

organism-sequence


PR:Q9QYH9-1 tumor necrosis factor ligand superfamily member 14 isoform 1 (mouse)
mTNFSF14/iso:1

sequence


PR:000002353 tumor necrosis factor ligand superfamily member 14 isoform 1
TNFSF14/iso:1

organism-sequence


PR:O43557-1 tumor necrosis factor ligand superfamily member 14 isoform 1 (human)
hTNFSF14/iso:1

organism-sequence


PR:Q9QYH9-1 tumor necrosis factor ligand superfamily member 14 isoform 1 (mouse)
mTNFSF14/iso:1

sequence


PR:000002354 tumor necrosis factor ligand superfamily member 14 isoform 2
TNFSF14/iso:2

organism-sequence


PR:O43557-2 tumor necrosis factor ligand superfamily member 14 isoform 2 (human)
hTNFSF14/iso:2

modification


PR:000018755 tumor necrosis factor ligand superfamily member 14 proteolytic cleavage product
TNFSF14/ClvPrd

gene


PR:000002223 tumor necrosis factor ligand superfamily member 15
TNFSF15

organism-gene


PR:O95150 tumor necrosis factor ligand superfamily member 15 (human)
hTNFSF15

organism-sequence


PR:O95150-1 tumor necrosis factor ligand superfamily member 15 isoform 1 (human)
hTNFSF15/iso:1

organism-sequence


PR:O95150-2 tumor necrosis factor ligand superfamily member 15 isoform 2 (human)
hTNFSF15/iso:2

organism-sequence


PR:O95150-3 tumor necrosis factor ligand superfamily member 15 isoform 3 (human)
hTNFSF15/iso:3

organism-gene


PR:Q50L61 TL1A (chicken)
chick-TNFSF15

organism-gene


PR:Q5UBV8 tumor necrosis factor ligand superfamily member 15 (mouse)
mTNFSF15

organism-sequence


PR:Q5UBV8-1 tumor necrosis factor ligand superfamily member 15 isoform 1 (mouse)
mTNFSF15/iso:1

organism-gene


PR:Q8K3Y7 tumor necrosis factor ligand superfamily member 15 (rat)
rTNFSF15

sequence


PR:000002355 tumor necrosis factor ligand superfamily member 15 isoform 1
TNFSF15/iso:1

organism-sequence


PR:O95150-1 tumor necrosis factor ligand superfamily member 15 isoform 1 (human)
hTNFSF15/iso:1

organism-sequence


PR:Q5UBV8-1 tumor necrosis factor ligand superfamily member 15 isoform 1 (mouse)
mTNFSF15/iso:1

sequence


PR:000002356 tumor necrosis factor ligand superfamily member 15 isoform 2
TNFSF15/iso:2

organism-sequence


PR:O95150-2 tumor necrosis factor ligand superfamily member 15 isoform 2 (human)
hTNFSF15/iso:2

sequence


PR:000002357 tumor necrosis factor ligand superfamily member 15 isoform 3
TNFSF15/iso:3

organism-sequence


PR:O95150-3 tumor necrosis factor ligand superfamily member 15 isoform 3 (human)
hTNFSF15/iso:3

modification


PR:000018756 tumor necrosis factor ligand superfamily member 15 proteolytic cleavage product
TNFSF15/ClvPrd

family


PR:000050043 lymphotoxin
fam:LT

gene


PR:000002204 lymphotoxin-alpha
LTA

organism-gene


PR:P01374 lymphotoxin-alpha (human)
hLTA

organism-sequence


PR:P01374-1 lymphotoxin-alpha isoform 1 (human)
hLTA/iso:1

organism-modification


PR:000048265 lymphotoxin-alpha, signal peptide removed form (human)
hLTA/SigPep-

organism-modification


PR:000051768 lymphotoxin-alpha N-glycosylated 1 (human)
hLTA/NGlyco:1

organism-modification


PR:000051769 lymphotoxin-alpha N-glycosylated 2 (human)
hLTA/NGlyco:2

organism-modification


PR:000051770 lymphotoxin-alpha N-glycosylated 3 (human)
hLTA/NGlyco:3

organism-modification


PR:000051771 lymphotoxin-alpha N-glycosylated 4 (human)
hLTA/NGlyco:4

organism-modification


PR:000051772 lymphotoxin-alpha N-glycosylated 5 (human)
hLTA/NGlyco:5

organism-modification


PR:000051773 lymphotoxin-alpha N-glycosylated 6 (human)
hLTA/NGlyco:6

organism-modification


PR:000066956 lymphotoxin-alpha deaminated 1 (human)
hLTA/Deam:1

organism-modification


PR:000073774 lymphotoxin-alpha methylated 1 (human)
hLTA/Me:1

organism-modification


PR:000074173 lymphotoxin-alpha deaminated 2 (human)
hLTA/Deam:2

organism-gene


PR:P09225 lymphotoxin-alpha (mouse)
mLTA

organism-sequence


PR:P09225-1 lymphotoxin-alpha isoform 1 (mouse)
mLTA/iso:1

organism-gene


PR:Q06332 lymphotoxin-alpha (rat)
rLTA

sequence


PR:000002331 lymphotoxin-alpha isoform 1
LTA/iso:1

organism-sequence


PR:P01374-1 lymphotoxin-alpha isoform 1 (human)
hLTA/iso:1

organism-sequence


PR:P09225-1 lymphotoxin-alpha isoform 1 (mouse)
mLTA/iso:1

modification


PR:000026648 lymphotoxin-alpha isoform 1, signal peptide removed form
LTA/iso:1/SigPep-

modification


PR:000018753 lymphotoxin-alpha, signal peptide removed form
LTA/SigPep-

modification


PR:000026648 lymphotoxin-alpha isoform 1, signal peptide removed form
LTA/iso:1/SigPep-

organism-modification


PR:000048265 lymphotoxin-alpha, signal peptide removed form (human)
hLTA/SigPep-

gene


PR:000002205 lymphotoxin-beta
LTB

organism-gene


PR:P41155 lymphotoxin-beta (mouse)
mLTB

organism-sequence


PR:P41155-1 lymphotoxin-beta isoform 1 (mouse)
mLTB/iso:1

organism-gene


PR:Q06643 lymphotoxin-beta (human)
hLTB

organism-sequence


PR:Q06643-1 lymphotoxin-beta isoform 1 (human)
hLTB/iso:1

organism-sequence


PR:Q06643-2 lymphotoxin-beta isoform h2 (human)
hLTB/iso:h2

sequence


PR:000002332 lymphotoxin-beta isoform 1
LTB/iso:1

organism-sequence


PR:P41155-1 lymphotoxin-beta isoform 1 (mouse)
mLTB/iso:1

sequence


PR:000002333 lymphotoxin-beta isoform 2
LTB/iso:2

organism-sequence


PR:Q06643-1 lymphotoxin-beta isoform 1 (human)
hLTB/iso:1

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fam:CBP-p300 forms found in complexes   

fam:CBP-p300 Component
 Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000036505 mTNF/iso:1/Clv:1 PMID:9305915
GO:0006915 apoptotic processPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
PR:000036504 hTNF/iso:1/Clv:1 PMID:3856324
PR:P01375-1 hTNF/iso:1 PMID:3856324
PR:P41047-1 mFASLG/iso:FasL PMID:16365167
GO:0007165 signal transductionPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
GO:0007267 cell-cell signalingPR:000000095 FASLG PANTHER:PTHR11471
GO:0043066 negative regulation of apoptotic processPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9396774
PR:P41047-1 mFASLG/iso:FasL MGI_ref:76989; PMID:7595210
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0043123 positive regulation of canonical NF-kappaB signal transductionPR:P48023-1 hFASLG/iso:FasL PMID:12761501
GO:0097190 apoptotic signaling pathwayPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:15039234

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:6688 autoimmune lymphoproliferative syndromePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
GO:0005125 cytokine activityPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
NOT GO:0005125 cytokine activityPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005164 tumor necrosis factor receptor bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
GO:0042802 identical protein bindingPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672; PMID:9228058; PMID:9405425
PR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005576 extracellular regionPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005615 extracellular spacePR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672
PR:000036505 mTNF/iso:1/Clv:1 PMID:10089307
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0005886 plasma membranePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745
PR:P01375-1 hTNF/iso:1 PMID:3349526
PR:P41047-1 mFASLG/iso:FasL PMID:16973387
GO:0009986 cell surfacePR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:16973387
GO:0016020 membranePR:000036507 hTNF/iso:1/Myr:1 PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1 PMID:10205166