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Protein Ontology report - DNA-binding protein inhibitor ID-3
PR:000000041 - http://purl.obolibrary.org/obo/PR_000000041
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000041   
  PRO nameDNA-binding protein inhibitor ID-3 
  Synonyms
PRO-Short-label: EXACT:ID3
Gene-based: RELATED:1R21 | BHLHB25 | HEIR1 | Hlh462 | Id-3 | Idb3
Other: EXACT:bHLHb25 | class B basic helix-loop-helix protein 25 | helix-loop-helix protein HEIR-1 | ID-like protein inhibitor HLH 1R21 | ID-like protein inhibitor HLH 462 | inhibitor of differentiation 3 | inhibitor of DNA binding 3
  Definition"An HLH DNA-binding protein inhibitor that is a translation product of the human ID3 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000003 HLH DNA-binding protein inhibitor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification4                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500479
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000041
DNA-binding protein inhibitor ID-3
ID3
"An HLH DNA-binding protein inhibitor that is a translation product of the human ID3 gene or a 1:1 ortholog thereof." [PRO:CNA]
Yes
organism-gene


PR:P41133
DNA-binding protein inhibitor ID-3 (mouse)
mID3
"A DNA-binding protein inhibitor ID-3 that is encoded in the genome of mouse." [OMA:P41133, PRO:DNx]

organism-sequence


PR:P41133-1
DNA-binding protein inhibitor ID-3 isoform 1 (mouse)
mID3/iso:1
"A DNA-binding protein inhibitor ID-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036430
DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
"A DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 in mouse." [PMID:15451666, PRO:CNA]
Yes
organism-gene


PR:P41138
DNA-binding protein inhibitor ID-3 (rat)
rID3
"A DNA-binding protein inhibitor ID-3 that is encoded in the genome of rat." [OMA:P41138, PRO:DNx]

organism-gene


PR:Q02535
DNA-binding protein inhibitor ID-3 (human)
hID3
"A DNA-binding protein inhibitor ID-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q02535]
Yes
organism-sequence


PR:Q02535-1
DNA-binding protein inhibitor ID-3 isoform 1 (human)
hID3/iso:1
"A DNA-binding protein inhibitor ID-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036429
DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 in human. UniProtKB:Q02535-1, Ser-5, MOD:00046." [PMID:9372912, PRO:CNA]
Yes
organism-modification


PR:000064894
DNA-binding protein inhibitor ID-3 methylated 1 (human)
hID3/Me:1
"A DNA-binding protein inhibitor ID-3 (human) that has been methylated on the residue at the position equivalent to Cys-47 of the amino acid sequence represented by UniProtKB:Q02535. UniProtKB:Q02535, Cys-47, MOD:00660." [IEDB_epitope:1005759, IEDB_epitope:1017395, PRO:DNx]

organism-modification


PR:000068204
DNA-binding protein inhibitor ID-3 cysteinylated 1 (human)
hID3/Cyst:1
"A DNA-binding protein inhibitor ID-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-47 of the amino acid sequence represented by UniProtKB:Q02535. UniProtKB:Q02535, Cys-47, MOD:00765." [IEDB_epitope:1587286, IEDB_epitope:880823, IEDB_epitope:926470, PRO:DNx]

organism-modification


PR:000073735
DNA-binding protein inhibitor ID-3 methylated 2 (human)
hID3/Me:2
"A DNA-binding protein inhibitor ID-3 (human) that has been methylated on the residue at the position equivalent to Cys-10 of the amino acid sequence represented by UniProtKB:Q02535. UniProtKB:Q02535, Cys-10, MOD:00660." [IEDB_epitope:1000695, IEDB_epitope:1050989, PRO:DNx]

organism-modification


PR:000081463
DNA-binding protein inhibitor ID-3 cysteinylated 2 (human)
hID3/Cyst:2
"A DNA-binding protein inhibitor ID-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-10 of the amino acid sequence represented by UniProtKB:Q02535. UniProtKB:Q02535, Cys-10, MOD:00765." [IEDB_epitope:1000694, PRO:DNx]

organism-modification


PR:000082453
DNA-binding protein inhibitor ID-3 phosphorylated 1 (human)
hID3/Phos:1
"A DNA-binding protein inhibitor ID-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-5 of the amino acid sequence represented by UniProtKB:Q02535. UniProtKB:Q02535, Ser-5, MOD:00046." [IEDB_epitope:1626412, PRO:DNx]

sequence


PR:000000174
DNA-binding protein inhibitor ID-3 isoform 1
ID3/iso:1
"A DNA-binding protein inhibitor ID-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02535-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P41133-1
DNA-binding protein inhibitor ID-3 isoform 1 (mouse)
mID3/iso:1
"A DNA-binding protein inhibitor ID-3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036430
DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
"A DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 in mouse." [PMID:15451666, PRO:CNA]
Yes
organism-sequence


PR:Q02535-1
DNA-binding protein inhibitor ID-3 isoform 1 (human)
hID3/iso:1
"A DNA-binding protein inhibitor ID-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036429
DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 in human. UniProtKB:Q02535-1, Ser-5, MOD:00046." [PMID:9372912, PRO:CNA]
Yes
modification


PR:000000393
DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated form
ID3/iso:1/PhosRes+
"A DNA-binding protein inhibitor ID-3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000508
DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1
ID3/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue in the N-terminal SPVR motif. Example: UniProtKB:Q02535-1, Ser-5, MOD:00046." [PRO:CNA, PRO:DAN]

organism-modification


PR:000036429
DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human)
hID3/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 in human. UniProtKB:Q02535-1, Ser-5, MOD:00046." [PMID:9372912, PRO:CNA]
Yes
modification


PR:000000394
DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated form
ID3/iso:1/UbiqLys+
"A DNA-binding protein inhibitor ID-3 isoform 1 that includes at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000509
DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1
ID3/iso:1/Ubiq:1
"A DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated form that has been ubiquitinated by COP9 signalosome complex for degradation." [PMID:15451666, PRO:CNA]

organism-modification


PR:000036430
DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse)
mID3/iso:1/Ubiq:1
"A DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 in mouse." [PMID:15451666, PRO:CNA]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000041 ID3 acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PIRSF:PIRSF500479
PR:000036429 hID3/iso:1/Phos:1
UniProtKB:Q02535-1, Ser-5, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:9372912
PR:000036430 mID3/iso:1/Ubiq:1 located_inGO:0005737 cytoplasm PMID:15451666
PR:P41133-1 mID3/iso:1 acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:2000388
located_inGO:0005634 nucleus PMID:15451666
PR:Q02535 hID3 acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:14627819
PR:Q02535-1 hID3/iso:1 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:1628620
GO:0045892 negative regulation of DNA-templated transcription PMID:8437843
enablesGO:0003714 transcription corepressor activity PMID:8437843