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Protein Ontology report - activin receptor type-1
PR:000000067 - http://purl.obolibrary.org/obo/PR_000000067
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000067   
  PRO nameactivin receptor type-1 
  Synonyms
PRO-Short-label: EXACT:ACVR1
Gene-based: RELATED:ACVRLK2 | Tgfb1
Other: EXACT:activin receptor type I | activin receptor-like kinase 2 | ACTR-I | ALK-2 | serine/threonine-protein kinase receptor R1 | SKR1 | TSK-7L
RELATED:TGF-B superfamily receptor type I | TSR-I
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1785
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000067

activin receptor type-1

ACVR1


"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P37172

activin receptor type-1 (mouse)

mACVR1


"An activin receptor type-1 that is encoded in the genome of mouse." [OMA:P37172, PRO:DNx]


organism-sequence



PR:P37172-1

activin receptor type-1 isoform 1 (mouse)

mACVR1/iso:1


"An activin receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036436

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]

Yes

organism-gene



PR:P80201

activin receptor type-1 (rat)

rACVR1


"An activin receptor type-1 that is encoded in the genome of rat." [OMA:P80201, PRO:DNx]


organism-gene



PR:Q04771

activin receptor type-1 (human)

hACVR1


"An activin receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q04771]


organism-sequence



PR:000000200

activin receptor type-1 sequence variant R206H (human)

hACVR1/var:R206H


"An activin receptor type-1 (human) that has a His residue at the position equivalent to Arg-206 of the amino acid sequence represented by UniProtKB:Q04771. This variation is located within the GS-motif. UniProtKB:Q04771, Arg-206, CHEBI:29979." [PMID:8397373, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q04771-1

activin receptor type-1 isoform 1 (human)

hACVR1/iso:1


"An activin receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036435

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]

Yes

organism-modification



PR:000068633

activin receptor type-1 cysteinylated 1 (human)

hACVR1/Cyst:1


"An activin receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-35 of the amino acid sequence represented by UniProtKB:Q04771. UniProtKB:Q04771, Cys-35, MOD:00765." [IEDB_epitope:2118215, PRO:DNx]


organism-gene



PR:Q90ZK6

activin receptor type-1 (chicken)

chick-ACVR1


"An activin receptor type-1 that is encoded in the genome of chicken." [OMA:Q90ZK6, PRO:DNx]


sequence



PR:000000199

activin receptor type-1 isoform 1

ACVR1/iso:1


"An activin receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04771-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P37172-1

activin receptor type-1 isoform 1 (mouse)

mACVR1/iso:1


"An activin receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036436

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]

Yes

organism-sequence



PR:Q04771-1

activin receptor type-1 isoform 1 (human)

hACVR1/iso:1


"An activin receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036435

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]

Yes

modification



PR:000021938

activin receptor type-1 isoform 1, signal peptide removed form

ACVR1/iso:1/SigPep-


"An activin receptor type-1 isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:DAN]


modification



PR:000000411

activin receptor type-1 isoform 1, signal peptide removed phosphorylated form

ACVR1/iso:1/SigPep-/PhosRes+


"An activin receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000524

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1

ACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs at Ser/Thr residues within the GS-motif region (GSGSGLP and surrounding sequence) by the activated activin receptor type-2 (PR:000000528 or PR:000000529)." [PRO:CNA]


organism-modification



PR:000036435

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human." [PMID:8242742, PMID:8389764, PMID:8397373, PRO:CNA]

Yes

organism-modification



PR:000036436

activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mACVR1/iso:1/SigPep-/Phos:1


"An activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse." [PMID:11376112, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742; PMID:8389764
PR:000036436 mACVR1/iso:1/SigPep-/Phos:1 PMID:11376112

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:13374 fibrodysplasia ossificans progressivaPR:000000200 hACVR1/var:R206H PMID:8397373

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004675 transmembrane receptor protein serine/threonine kinase activityPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8389764
GO:0048185 activin bindingPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000000200 hACVR1/var:R206H PMID:8397373
PR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742; PMID:8397373
GO:0048179 activin receptor complexPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742