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Protein Ontology report - activin receptor type-1C
PR:000000069 - http://purl.obolibrary.org/obo/PR_000000069
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000069   
  PRO nameactivin receptor type-1C 
  Synonyms
PRO-Short-label: EXACT:ACVR1C
Gene-based: RELATED:ALK7
Other: EXACT:activin receptor type IC | activin receptor-like kinase 7 | ACTR-IC | ALK-7
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1C gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 7                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1790
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000069

activin receptor type-1C

ACVR1C


"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1C gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P70539

activin receptor type-1C (rat)

rACVR1C


"An activin receptor type-1C that is encoded in the genome of rat." [OMA:P70539, PRO:DNx]


organism-gene



PR:Q8K348

activin receptor type-1C (mouse)

mACVR1C


"An activin receptor type-1C that is encoded in the genome of mouse." [OMA:Q8K348, PRO:DNx]


organism-sequence



PR:A2AJR5

activin receptor type-1C isoform 3 (mouse)

mACVR1C/iso:3


"An activin receptor type-1C isoform 3 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]


organism-sequence



PR:A2AJR6

activin receptor type-1C isoform 2 (mouse)

mACVR1C/iso:2


"An activin receptor type-1C isoform 2 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8K348-1

activin receptor type-1C isoform 1 (mouse)

mACVR1C/iso:1


"An activin receptor type-1C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q8NER5

activin receptor type-1C (human)

hACVR1C


"An activin receptor type-1C that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NER5]


organism-sequence



PR:Q8NER5-1

activin receptor type-1C isoform 1 (human)

hACVR1C/iso:1


"An activin receptor type-1C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036439

activin receptor type-1C isoform 1 phosphorylated 1 (human)

hACVR1C/iso:1/Phos:1


"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]

Yes

organism-sequence



PR:Q8NER5-2

activin receptor type-1C isoform 2 (human)

hACVR1C/iso:2


"An activin receptor type-1C isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8NER5-3

activin receptor type-1C isoform 3 (human)

hACVR1C/iso:3


"An activin receptor type-1C isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8NER5-4

activin receptor type-1C isoform 4 (human)

hACVR1C/iso:4


"An activin receptor type-1C isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000060490

activin receptor type-1C, signal peptide removed form (human)

hACVR1C/SigPep-


"An activin receptor type-1C (human) that has had the signal peptide removed. Example: UniProtKB:Q8NER5-1, 21-493." [PRO:DNx, Reactome:R-HSA-1181117]


organism-modification



PR:000063700

activin receptor type-1C, signal peptide removed phosphorylated 1 (human)

hACVR1C/SigPep-/Phos:1


"An activin receptor type-1C (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Thr-175, Ser-177, Ser-179, Ser-181, and Thr-194 of the amino acid sequence represented by UniProtKB:Q8NER5-1. Example: UniProtKB:Q8NER5-1, 21-493, Thr-175/Thr-194, MOD:00047|Ser-177/Ser-179/Ser-181, MOD:00046." [PRO:DNx, Reactome:R-HSA-1181110]


sequence



PR:000000204

activin receptor type-1C isoform 1

ACVR1C/iso:1


"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8K348-1

activin receptor type-1C isoform 1 (mouse)

mACVR1C/iso:1


"An activin receptor type-1C isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8NER5-1

activin receptor type-1C isoform 1 (human)

hACVR1C/iso:1


"An activin receptor type-1C isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036439

activin receptor type-1C isoform 1 phosphorylated 1 (human)

hACVR1C/iso:1/Phos:1


"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]

Yes

modification



PR:000000413

activin receptor type-1C isoform 1 phosphorylated form

ACVR1C/iso:1/PhosRes+


"An activin receptor type-1C isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000527

activin receptor type-1C isoform 1 phosphorylated 1

ACVR1C/iso:1/Phos:1


"An activin receptor type-1C isoform 1 phosphorylated form that is phosphorylated at Ser/Thr residues in the GS-motif by activated activin receptor type-2, and constitutes an active receptor subunit." [PMID:15196700]


organism-modification



PR:000036439

activin receptor type-1C isoform 1 phosphorylated 1 (human)

hACVR1C/iso:1/Phos:1


"An activin receptor type-1C isoform 1 phosphorylated 1 in human." [PMID:12063393, PMID:12065756, PMID:12606401, PMID:15196700, PMID:15531507, PRO:CNA]

Yes

sequence



PR:000000205

activin receptor type-1C isoform 2

ACVR1C/iso:2


"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-2 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]


organism-sequence



PR:A2AJR6

activin receptor type-1C isoform 2 (mouse)

mACVR1C/iso:2


"An activin receptor type-1C isoform 2 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8NER5-2

activin receptor type-1C isoform 2 (human)

hACVR1C/iso:2


"An activin receptor type-1C isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000206

activin receptor type-1C isoform 3

ACVR1C/iso:3


"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-3 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]


organism-sequence



PR:A2AJR5

activin receptor type-1C isoform 3 (mouse)

mACVR1C/iso:3


"An activin receptor type-1C isoform 3 that is encoded in the genome of mouse." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8NER5-3

activin receptor type-1C isoform 3 (human)

hACVR1C/iso:3


"An activin receptor type-1C isoform 3 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000207

activin receptor type-1C isoform 4

ACVR1C/iso:4


"An activin receptor type-1C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NER5-4 or a 1:1 ortholog thereof." [PMID:12606401, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8NER5-4

activin receptor type-1C isoform 4 (human)

hACVR1C/iso:4


"An activin receptor type-1C isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006468 protein phosphorylationPR:000036439 hACVR1C/iso:1/Phos:1 PMID:12065756
GO:0042981 regulation of apoptotic processPR:000036439 hACVR1C/iso:1/Phos:1 PMID:15531507

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0016361 activin receptor activity, type IPR:000036439 hACVR1C/iso:1/Phos:1 PMID:12063393; PMID:15196700

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000036439 hACVR1C/iso:1/Phos:1 PMID:12606401
PR:Q8NER5-4 hACVR1C/iso:4 PMID:12606401
GO:0048179 activin receptor complexPR:000036439 hACVR1C/iso:1/Phos:1 PMID:15531507