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Protein Ontology report - activin receptor type-2A
PR:000000070 - http://purl.obolibrary.org/obo/PR_000000070
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000070   
  PRO nameactivin receptor type-2A 
  Synonyms
PRO-Short-label: EXACT:ACVR2A
Gene-based: RELATED:ACVR2
Other: EXACT:activin receptor type IIA | ACTR-IIA | ACTRIIA
  Definition"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2A gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500457;IUPHARobj:1791
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000070

activin receptor type-2A

ACVR2A


"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2A gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P27037

activin receptor type-2A (human)

hACVR2A


"An activin receptor type-2A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P27037]


organism-sequence



PR:P27037-1

activin receptor type-2A isoform 1 (human)

hACVR2A/iso:1


"An activin receptor type-2A isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P27037]


organism-modification



PR:000036441

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)

hACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in human." [PMID:12665502, PMID:1314589, PMID:8622651, PRO:CNA]

Yes

organism-sequence



PR:P27037-2

activin receptor type-2A isoform h2 (human)

hACVR2A/iso:h2


"An activin receptor type-2A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27037-2." [PRO:DNx, UniProtKB:P27037]


organism-modification



PR:000046258

activin receptor type-2A, signal peptide removed form (human)

hACVR2A/SigPep-


"An activin receptor type-2A (human) that has had the signal peptide removed. UniProtKB:P27037, 20-513." [PRO:DNx, Reactome:R-HSA-201659]


organism-gene



PR:P27038

activin receptor type-2A (mouse)

mACVR2A


"An activin receptor type-2A that is encoded in the genome of mouse." [OMA:P27038, PRO:DNx]


organism-sequence



PR:P27038-1

activin receptor type-2A isoform 1 (mouse)

mACVR2A/iso:1


"An activin receptor type-2A isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P27038]

Yes

organism-modification



PR:000036440

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)

mACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:16991118, PMID:7885474, PMID:8395525, PMID:8612709, PRO:CNA]

Yes

organism-gene



PR:P38444

activin receptor type-2A (rat)

rACVR2A


"An activin receptor type-2A that is encoded in the genome of rat." [OMA:P38444, PRO:DNx]


organism-gene



PR:Q90669

activin receptor type-2A (chicken)

chick-ACVR2A


"An activin receptor type-2A that is encoded in the genome of chicken." [OMA:Q90669, PRO:DNx]


sequence



PR:000000208

activin receptor type-2A isoform 1

ACVR2A/iso:1


"An activin receptor type-2A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27038-1 or a 1:1 ortholog thereof." [PMID:8395525, PRO:CNA, PRO:DAN]


organism-sequence



PR:P27037-1

activin receptor type-2A isoform 1 (human)

hACVR2A/iso:1


"An activin receptor type-2A isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P27037]


organism-modification



PR:000036441

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)

hACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in human." [PMID:12665502, PMID:1314589, PMID:8622651, PRO:CNA]

Yes

organism-sequence



PR:P27038-1

activin receptor type-2A isoform 1 (mouse)

mACVR2A/iso:1


"An activin receptor type-2A isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P27038]

Yes

organism-modification



PR:000036440

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)

mACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:16991118, PMID:7885474, PMID:8395525, PMID:8612709, PRO:CNA]

Yes

modification



PR:000000414

activin receptor type-2A isoform 1 glycosylated and phosphorylated form

ACVR2A/iso:1/GlycoPhos+


"An activin receptor type-2A isoform 1 that includes at least one glycosylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000528

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1

ACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated form in which the phosphorylation occurs at Ser/Thr residues. This constitutes the active receptor subunit." [PMID:8395525]


organism-modification



PR:000036440

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)

mACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:16991118, PMID:7885474, PMID:8395525, PMID:8612709, PRO:CNA]

Yes

organism-modification



PR:000036441

activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)

hACVR2A/iso:1/GlycoPhos:1


"An activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 in human." [PMID:12665502, PMID:1314589, PMID:8622651, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000070 ACVR2A acts_upstream_of_or_withinGO:0032924 activin receptor signaling pathway PIRSF:PIRSF500457
enablesGO:0048185 activin binding PIRSF:PIRSF500457
PR:000036440 mACVR2A/iso:1/GlycoPhos:1 acts_upstream_of_or_withinGO:0008584 male gonad development PMID:7885474
GO:0009952 anterior/posterior pattern specification PMID:10452853; PMID:16991118
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8395525
GO:0016362 activin receptor activity, type II PMID:8395525
GO:0019838 growth factor binding PMID:11459935; PMID:12414726
GO:0042803 protein homodimerization activity PMID:8612709
located_inGO:0048179 activin receptor complex PMID:8395525
PR:000036441 hACVR2A/iso:1/GlycoPhos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:1314589
enablesGO:0016362 activin receptor activity, type II PMID:12665502
located_inGO:0005886 plasma membrane PMID:1314589
GO:0048179 activin receptor complex PMID:8622651
PR:P27038-1 mACVR2A/iso:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8395525