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Protein Ontology report - activin/inhibin beta subunit
PR:000000072 - http://purl.obolibrary.org/obo/PR_000000072
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000072   
  PRO nameactivin/inhibin beta subunit 
  Definition"A TGF-beta-like cystine-knot cytokine that is the beta subunit of inhibin and activin complexes. Related to the transforming growth factor-beta, anti-Muellerian hormone, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence4                                                  Organism-Sequence 8                                        
         Modification12                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037268
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000072 activin/inhibin beta subunit
ACVR2B
Yes
gene


PR:000000216 activin/inhibin beta A chain
INHBA

organism-gene


PR:P08476 inhibin beta A chain (human)
hINHBA

organism-sequence


PR:P08476-1 inhibin beta A chain isoform 1 (human)
hINHBA/iso:1
Yes
organism-modification


PR:000036540 activin/inhibin beta A chain isoform 1 cleaved 1 (human)
hINHBA/iso:1/Clv:1
Yes
organism-modification


PR:000054446 inhibin beta A chain O-glycosylated 1 (human)
hINHBA/OGlyco:1

organism-gene


PR:P18331 inhibin beta A chain (rat)
rINHBA

organism-gene


PR:P27092 inhibin beta A chain (chicken)
chick-INHBA

organism-gene


PR:Q04998 inhibin beta A chain (mouse)
mINHBA

organism-sequence


PR:Q04998-1 inhibin beta A chain isoform 1 (mouse)
mINHBA/iso:1

organism-modification


PR:000036539 activin/inhibin beta A chain isoform 1 cleaved 1 (mouse)
mINHBA/iso:1/Clv:1
Yes
sequence


PR:000000416 activin/inhibin beta A chain isoform 1
INHBA/iso:1

organism-sequence


PR:P08476-1 inhibin beta A chain isoform 1 (human)
hINHBA/iso:1
Yes
organism-modification


PR:000036540 activin/inhibin beta A chain isoform 1 cleaved 1 (human)
hINHBA/iso:1/Clv:1
Yes
organism-sequence


PR:Q04998-1 inhibin beta A chain isoform 1 (mouse)
mINHBA/iso:1

organism-modification


PR:000036539 activin/inhibin beta A chain isoform 1 cleaved 1 (mouse)
mINHBA/iso:1/Clv:1
Yes
modification


PR:000021911 activin/inhibin beta A chain isoform 1, signal peptide removed form
INHBA/iso:1/SigPep-

modification


PR:000000637 activin/inhibin beta A chain isoform 1 cleaved 1
INHBA/iso:1/Clv:1

organism-modification


PR:000036539 activin/inhibin beta A chain isoform 1 cleaved 1 (mouse)
mINHBA/iso:1/Clv:1
Yes
organism-modification


PR:000036540 activin/inhibin beta A chain isoform 1 cleaved 1 (human)
hINHBA/iso:1/Clv:1
Yes
modification


PR:000018295 activin/inhibin beta A chain proteolytic cleavage product
INHBA/ClvPrd

gene


PR:000000217 activin/inhibin beta B chain
INHBB

organism-gene


PR:P09529 inhibin beta B chain (human)
hINHBB

organism-sequence


PR:P09529-1 inhibin beta B chain isoform 1 (human)
hINHBB/iso:1

organism-modification


PR:000036541 activin/inhibin beta B chain isoform 1 cleaved 1 (human)
hINHBB/iso:1/Clv:1
Yes
organism-modification


PR:000054651 inhibin beta B chain O-glycosylated 1 (human)
hINHBB/OGlyco:1

organism-modification


PR:000054652 inhibin beta B chain O-glycosylated 2 (human)
hINHBB/OGlyco:2

organism-gene


PR:P17491 inhibin beta B chain (rat)
rINHBB

organism-gene


PR:P27093 inhibin beta B chain (chicken)
chick-INHBB

organism-gene


PR:Q04999 inhibin beta B chain (mouse)
mINHBB

organism-sequence


PR:Q04999-1 inhibin beta B chain isoform 1 (mouse)
mINHBB/iso:1

sequence


PR:000000417 activin/inhibin beta B chain isoform 1
INHBB/iso:1

organism-sequence


PR:P09529-1 inhibin beta B chain isoform 1 (human)
hINHBB/iso:1

organism-modification


PR:000036541 activin/inhibin beta B chain isoform 1 cleaved 1 (human)
hINHBB/iso:1/Clv:1
Yes
organism-sequence


PR:Q04999-1 inhibin beta B chain isoform 1 (mouse)
mINHBB/iso:1

modification


PR:000021912 activin/inhibin beta B chain isoform 1, signal peptide removed form
INHBB/iso:1/SigPep-

modification


PR:000000638 activin/inhibin beta B chain isoform 1 cleaved 1
INHBB/iso:1/Clv:1

organism-modification


PR:000036541 activin/inhibin beta B chain isoform 1 cleaved 1 (human)
hINHBB/iso:1/Clv:1
Yes
modification


PR:000021927 activin/inhibin beta B chain proteolytic cleavage product
INHBB/ClvPrd

gene


PR:000000218 activin/inhibin beta C chain
INHBC

organism-gene


PR:P55103 inhibin beta C chain (human)
hINHBC

organism-sequence


PR:P55103-1 inhibin beta C chain isoform 1 (human)
hINHBC/iso:1

organism-modification


PR:000036545 inhibin beta C chain isoform 1 cleaved 1 (human)
hINHBC/iso:1/Clv:1
Yes
organism-gene


PR:P55104 inhibin beta C chain (mouse)
mINHBC

organism-sequence


PR:P55104-1 inhibin beta C chain isoform 1 (mouse)
mINHBC/iso:1

organism-gene


PR:Q9WUK5 inhibin beta C chain (rat)
rINHBC

sequence


PR:000000444 inhibin beta C chain isoform 1
INHBC/iso:1

organism-sequence


PR:P55103-1 inhibin beta C chain isoform 1 (human)
hINHBC/iso:1

organism-modification


PR:000036545 inhibin beta C chain isoform 1 cleaved 1 (human)
hINHBC/iso:1/Clv:1
Yes
organism-sequence


PR:P55104-1 inhibin beta C chain isoform 1 (mouse)
mINHBC/iso:1

modification


PR:000021916 inhibin beta C chain isoform 1, signal peptide removed form
INHBC/iso:1/SigPep-

modification


PR:000000642 inhibin beta C chain isoform 1 cleaved 1
INHBC/iso:1/Clv:1

organism-modification


PR:000036545 inhibin beta C chain isoform 1 cleaved 1 (human)
hINHBC/iso:1/Clv:1
Yes
modification


PR:000021933 activin/inhibin beta C chain proteolytic cleavage product
INHBC/ClvPrd

gene


PR:000000219 activin/inhibin beta E chain
INHBE

organism-gene


PR:O08717 inhibin beta E chain (mouse)
mINHBE

organism-sequence


PR:O08717-1 inhibin beta E chain isoform 1 (mouse)
mINHBE/iso:1

organism-modification


PR:000036542 activin/inhibin beta E chain isoform 1 cleaved 1 (mouse)
mINHBE/iso:1/Clv:1
Yes
organism-gene


PR:O88959 inhibin beta E chain (rat)
rINHBE

organism-gene


PR:P58166 inhibin beta E chain (human)
hINHBE

organism-sequence


PR:P58166-1 inhibin beta E chain isoform 1 (human)
hINHBE/iso:1

organism-modification


PR:000056664 inhibin beta E chain O-glycosylated 1 (human)
hINHBE/OGlyco:1

sequence


PR:000000418 activin/inhibin beta E chain isoform 1
INHBE/iso:1

organism-sequence


PR:O08717-1 inhibin beta E chain isoform 1 (mouse)
mINHBE/iso:1

organism-modification


PR:000036542 activin/inhibin beta E chain isoform 1 cleaved 1 (mouse)
mINHBE/iso:1/Clv:1
Yes
organism-sequence


PR:P58166-1 inhibin beta E chain isoform 1 (human)
hINHBE/iso:1

modification


PR:000021913 activin/inhibin beta E chain isoform 1, signal peptide removed form
INHBE/iso:1/SigPep-

modification


PR:000000639 activin/inhibin beta E chain isoform 1 cleaved 1
INHBE/iso:1/Clv:1

organism-modification


PR:000036542 activin/inhibin beta E chain isoform 1 cleaved 1 (mouse)
mINHBE/iso:1/Clv:1
Yes
modification


PR:000021928 activin/inhibin beta E chain proteolytic cleavage product
INHBE/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000072 ACVR2B
Related to the transforming growth factor-beta, anti-Muellerian hormone, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation		 enablesGO:0005102 signaling receptor binding PIRSF:PIRSF037268
PR:000036539 mINHBA/iso:1/Clv:1
UniProtKB:Q04998-1, 309-424		 enablescontributes_to GO:0005102 signaling receptor binding PMID:1646080; PMID:7577669
GO:0046983 protein dimerization activity PMID:2133547
PR:000036540 hINHBA/iso:1/Clv:1
UniProtKB:P08476-1, 311-426		 acts_upstream_of_or_withinGO:0007166 cell surface receptor signaling pathway PMID:12456957
GO:0007267 cell-cell signaling PMID:12456957
GO:0009605 response to external stimulus PMID:10320815
GO:0030154 cell differentiation PMID:12456957
GO:0032925 regulation of activin receptor signaling pathway PMID:9884026
enablescontributes_to GO:0005102 signaling receptor binding PMID:7890768
GO:0046983 protein dimerization activity PMID:1537316
located_inGO:0005576 extracellular region PMID:12213882; PMID:2575216
GO:0032991 protein-containing complex PMID:12960042
GO:0043509 activin A complex PMID:7890768
GO:0043512 inhibin A complex PMID:17456790; PMID:7890768
PR:000036541 hINHBB/iso:1/Clv:1
UniProtKB:P09529-1, 293-407		 acts_upstream_of_or_withinGO:0030154 cell differentiation PMID:10320815
GO:0046880 regulation of follicle-stimulating hormone secretion PMID:3122219
enablescontributes_to GO:0005102 signaling receptor binding PMID:3754442
GO:0005515 protein binding PMID:2575216
GO:0046983 protein dimerization activity PMID:2575216
located_inGO:0005576 extracellular region PMID:3122219
PR:000036542 mINHBE/iso:1/Clv:1
UniProtKB:O08717-1, 237-350		 acts_upstream_of_or_withinGO:0043065 positive regulation of apoptotic process PMID:15863943
enablesGO:0046983 protein dimerization activity PMID:15863943
located_inGO:0005576 extracellular region PMID:15863943
GO:0048180 activin complex PMID:15863943
PR:000036545 hINHBC/iso:1/Clv:1
UniProtKB:P55103-1, 237-352		 acts_upstream_of_or_withinGO:0032926 negative regulation of activin receptor signaling pathway PMID:12960042; PMID:16627954
enablescontributes_to GO:0005160 transforming growth factor beta receptor binding PMID:7826378
GO:0046983 protein dimerization activity PMID:11134153
located_inGO:0005576 extracellular region PMID:16627954; PMID:7826378
GO:0032991 protein-containing complex PMID:11134153; PMID:12960042
PR:P08476-1 hINHBA/iso:1 acts_upstream_of_or_withinGO:0001541 ovarian follicle development PMID:9166111
GO:0007165 signal transduction PMID:3267209
GO:0007267 cell-cell signaling PMID:12456957
GO:0007399 nervous system development PMID:10320815
GO:0030154 cell differentiation PMID:12456957
GO:0050789 regulation of biological process PMID:12419948; PMID:3122219