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Protein Ontology report - Muellerian-inhibiting factor
PR:000000073 - http://purl.obolibrary.org/obo/PR_000000073
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000073   
  PRO nameMuellerian-inhibiting factor 
  Synonyms
PRO-Short-label: EXACT:AMH
Gene-based: RELATED:MIF
Other: EXACT:anti-Muellerian hormone | Muellerian-inhibiting substance
RELATED:MIS
  Definition"A TGF-beta-like cystine-knot cytokine that is a translation product of the human AMH gene or a 1:1 ortholog thereof. Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 10                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037270
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000073 Muellerian-inhibiting factor
AMH
Yes
organism-gene


PR:P03971 Muellerian-inhibiting factor (human)
hAMH

organism-sequence


PR:000000221 Muellerian-inhibiting factor sequence variant V12G (human)
hAMH/var:V12G
Yes
organism-sequence


PR:000000222 Muellerian-inhibiting factor sequence variant L70P (human)
hAMH/var:L70P
Yes
organism-sequence


PR:000000223 Muellerian-inhibiting factor sequence variant G101V (human)
hAMH/var:G101V
Yes
organism-sequence


PR:000000224 Muellerian-inhibiting factor sequence variant R123W (human)
hAMH/var:R123W
Yes
organism-sequence


PR:000000225 Muellerian-inhibiting factor sequence variant Y167C (human)
hAMH/var:Y167C
Yes
organism-sequence


PR:000000226 Muellerian-inhibiting factor sequence variant R194C (human)
hAMH/var:R194C
Yes
organism-sequence


PR:000000227 Muellerian-inhibiting factor sequence variant V477A (human)
hAMH/var:V477A
Yes
organism-sequence


PR:P03971-1 Muellerian-inhibiting factor isoform 1 (human)
hAMH/iso:1
Yes
organism-modification


PR:000036605 Muellerian-inhibiting factor isoform 1 cleaved 1 (human)
hAMH/iso:1/Clv:1
Yes
organism-modification


PR:000036444 Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human)
hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000053160 Muellerian-inhibiting factor O-glycosylated 1 (human)
hAMH/OGlyco:1

organism-modification


PR:000053161 Muellerian-inhibiting factor O-glycosylated 2 (human)
hAMH/OGlyco:2

organism-gene


PR:P27106 Muellerian-inhibiting factor (mouse)
mAmh

organism-sequence


PR:P27106-1 Muellerian-inhibiting factor isoform 1 (mouse)
mAmh/iso:1

organism-gene


PR:P49000 Muellerian-inhibiting factor (rat)
rAMH

organism-sequence


PR:P49000-1 Muellerian-inhibiting factor isoform 1 (rat)
rAMH/iso:1

organism-modification


PR:000036606 Muellerian-inhibiting factor isoform 1 cleaved 1 (rat)
rAMH/iso:1/Clv:1
Yes
sequence


PR:000000220 Muellerian-inhibiting factor isoform 1
AMH/iso:1

organism-sequence


PR:P03971-1 Muellerian-inhibiting factor isoform 1 (human)
hAMH/iso:1
Yes
organism-modification


PR:000036605 Muellerian-inhibiting factor isoform 1 cleaved 1 (human)
hAMH/iso:1/Clv:1
Yes
organism-modification


PR:000036444 Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human)
hAMH/iso:1/ClvNGlyco:2
Yes
organism-sequence


PR:P27106-1 Muellerian-inhibiting factor isoform 1 (mouse)
mAmh/iso:1

organism-sequence


PR:P49000-1 Muellerian-inhibiting factor isoform 1 (rat)
rAMH/iso:1

organism-modification


PR:000036606 Muellerian-inhibiting factor isoform 1 cleaved 1 (rat)
rAMH/iso:1/Clv:1
Yes
modification


PR:000021919 Muellerian-inhibiting factor isoform 1, signal peptide removed form
AMH/iso:1/SigPep-

modification


PR:000001277 Muellerian-inhibiting factor isoform 1 cleaved 1
AMH/iso:1/Clv:1

modification


PR:000000419 Muellerian-inhibiting factor isoform 1 cleaved and glycosylated form
AMH/iso:1/ClvGlyco+

modification


PR:000000534 Muellerian-inhibiting factor isoform 1 cleaved and glycosylated 2
AMH/iso:1/ClvGlyco:2

organism-modification


PR:000036444 Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human)
hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036605 Muellerian-inhibiting factor isoform 1 cleaved 1 (human)
hAMH/iso:1/Clv:1
Yes
organism-modification


PR:000036444 Muellerian-inhibiting factor isoform 1 cleaved and N-glycosylated 2 (human)
hAMH/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036606 Muellerian-inhibiting factor isoform 1 cleaved 1 (rat)
rAMH/iso:1/Clv:1
Yes
modification


PR:000001276 Muellerian-inhibiting factor proteolytic cleavage product
AMH/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000073 AMH
Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation		 acts_upstream_of_or_withinGO:0007548 sex differentiation PIRSF:PIRSF037270
GO:0008406 gonad development PIRSF:PIRSF037270
enablesGO:0005102 signaling receptor binding PIRSF:PIRSF037270
GO:0005179 hormone activity PIRSF:PIRSF037270
PR:000000221 hAMH/var:V12G
UniProtKB:P03971, Val-12, CHEBI:29947		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8162013
PR:000000222 hAMH/var:L70P
UniProtKB:P03971, Leu-70, CHEBI:50342		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8162013
PR:000000223 hAMH/var:G101V
UniProtKB:P03971, Gly-101, CHEBI:30015		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8162013
PR:000000224 hAMH/var:R123W
UniProtKB:P03971, Arg-123, CHEBI:29954		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8162013
PR:000000225 hAMH/var:Y167C
UniProtKB:P03971, Tyr-167, CHEBI:29950		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:8162013
PR:000000226 hAMH/var:R194C
UniProtKB:P03971, Arg-194, CHEBI:29950		 associated_with_disease_progressionDO:0050791 persistent Mullerian duct syndrome PMID:14673134; PMID:8162013
located_inSO:0001555 decreased_translational_product_level PMID:14673134; PMID:8162013
SO:0001558 polypeptide_localization_variant PMID:14673134; PMID:8162013
PR:000000227 hAMH/var:V477A
UniProtKB:P03971, Val-477, CHEBI:46217		 located_inSO:0001558 polypeptide_localization_variant PMID:8162013
PR:000036444 hAMH/iso:1/ClvNGlyco:2
UniProtKB:P03971-1, 26-450, 451-560, MOD:00160		 acts_upstream_of_or_withinGO:0001880 Mullerian duct regression PMID:14750901; PMID:3754790
GO:0007267 cell-cell signaling PMID:3754790
GO:0007548 sex differentiation PMID:12834017
enablesGO:0005102 signaling receptor binding PMID:14750901
GO:0005179 hormone activity PMID:14750901
GO:0046983 protein dimerization activity PMID:14673134
located_inGO:0005576 extracellular region PMID:14750901; PMID:3754790
PR:000036605 hAMH/iso:1/Clv:1
UniProtKB:P03971-1, 451-560		 enablesGO:0046983 protein dimerization activity PMID:14673134
PR:000036606 rAMH/iso:1/Clv:1
UniProtKB:P49000-1, 446-553		 located_inGO:0005576 extracellular region PMID:8755541
PR:P03971-1 hAMH/iso:1 acts_upstream_of_or_withinGO:0001880 Mullerian duct regression PMID:14750901
GO:0007548 sex differentiation PMID:12834017