back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - fungal/metazoan cullin-1
PR:000000092 - http://purl.obolibrary.org/obo/PR_000000092
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000092   
  PRO namefungal/metazoan cullin-1 
  Synonyms
PRO-Short-label: EXACT:CUL1
Other: EXACT:CUL-1
  Definition"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000013 cullin
PR:000036194 eukaryotic protein
  TaxonNCBITaxon:33154 Opisthokonta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000092

fungal/metazoan cullin-1

CUL1


"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA]

Yes

organism-gene



PR:O13790

cullin-1 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O13790, PRO:DNx]


organism-gene



PR:O60999

cullin-1 (Dictyostelium discoideum)

Dicty-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of Dictyostelium discoideum." [OMA:O60999, PRO:DNx]


organism-gene



PR:Q12018

cell division control protein 53 (yeast)

yCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of yeast." [OMA:Q12018, PRO:DNx]


organism-gene



PR:Q13616

cullin-1 (human)

hCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:Q13616-1

cullin-1 isoform 1 (human)

hCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

organism-modification



PR:000064861

cullin-1 neddylated 1 (human)

hCUL1/Nedd:1


"A cullin-1 (human) that has been neddylated on the residue at the position equivalent to Lys-720 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Lys-720, MOD:01150." [PRO:DNx, Reactome:R-HSA-8952519]


organism-modification



PR:000071994

cullin-1 methylated 1 (human)

hCUL1/Me:1


"A cullin-1 (human) that has been methylated on the residue at the position equivalent to Cys-355 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-355, MOD:00660." [IEDB_epitope:1020279, PRO:DNx]


organism-modification



PR:000075174

cullin-1 cysteinylated 1 (human)

hCUL1/Cyst:1


"A cullin-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-551 of the amino acid sequence represented by UniProtKB:Q13616. UniProtKB:Q13616, Cys-551, MOD:00765." [IEDB_epitope:1583373, IEDB_epitope:1593153, PRO:DNx]


organism-gene



PR:Q17389

cullin-1 (worm)

CUL1 (worm)


"A fungal/metazoan cullin-1 that is encoded in the genome of worm." [OMA:Q17389, PRO:DNx]


organism-gene



PR:Q24311

cullin homolog 1 (fruit fly)

fly-CUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of fruit fly." [OMA:Q24311, PRO:DNx]


organism-gene



PR:Q9WTX6

cullin-1 (mouse)

mCUL1


"A fungal/metazoan cullin-1 that is encoded in the genome of mouse." [OMA:Q9WTX6, PRO:DNx]


organism-sequence



PR:Q9WTX6-1

cullin-1 isoform 1 (mouse)

mCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000267

fungal/metazoan cullin-1 isoform 1

CUL1/iso:1


"A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13616-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q13616-1

cullin-1 isoform 1 (human)

hCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

organism-sequence



PR:Q9WTX6-1

cullin-1 isoform 1 (mouse)

mCUL1/iso:1


"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000427

fungal/metazoan cullin-1 isoform 1 neddylated form

CUL1/iso:1/NeddLys+


"A fungal/metazoan cullin-1 isoform 1 that includes at least one neddylated lysine." [PRO:CNA]


modification



PR:000000542

fungal/metazoan cullin-1 isoform 1 neddylated 1

CUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated form that has been neddylated in the conserved Lys residue within the IVR[ILV]MKxR[RK] motif. Example: UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156]


organism-modification



PR:000036454

cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1


"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]

Yes

Back to top
CUL1 forms found in complexes   

CUL1 Component
Complexes
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0008285 negative regulation of cell population proliferationPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processPR:000000092 CUL1 PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cyclePR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathwayPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005515 protein bindingPR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0019005 SCF ubiquitin ligase complexPR:000000092 CUL1 PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923; PMID:17098746
NOT GO:0019005 SCF ubiquitin ligase complexPR:Q13616-1 hCUL1/iso:1 PMID:10713156; PMID:10921923; PMID:12504026