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Protein Ontology report - growth/differentiation factor
PR:000000098 - http://purl.obolibrary.org/obo/PR_000000098
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000098   
  PRO namegrowth/differentiation factor 
  Definition"A TGF-beta-like cystine-knot cytokine that is closely related to the BMP family. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release the bioactive C-terminal peptide. GDFs act as signaling molecules during embryonic tendon/ligament formation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 9                                        
         Modification6                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
family


PR:000000098 growth/differentiation factor
FST/iso:2

gene


PR:000000281 growth/differentiation factor 5
GDF5
Yes
organism-gene


PR:P43026 growth/differentiation factor 5 (human)
hGDF5

organism-sequence


PR:000000437 growth/differentiation factor 5 sequence variant C400Y (human)
hGDF5/var:C400Y
Yes
organism-sequence


PR:000000438 growth/differentiation factor 5 sequence variant R438L (human)
hGDF5/var:R438L
Yes
organism-sequence


PR:000000439 growth/differentiation factor 5 sequence variant L441P (human)
hGDF5/var:L441P
Yes
organism-sequence


PR:P43026-1 growth/differentiation factor 5 isoform 1 (human)
hGDF5/iso:1
Yes
organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
organism-modification


PR:000047523 growth/differentiation factor 5, signal peptide removed form (human)
hGDF5/SigPep-

organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
organism-gene


PR:P43027 growth/differentiation factor 5 (mouse)
mGDF5

organism-sequence


PR:000000441 growth/differentiation factor 5 sequence variant 5 (mouse)
mGDF5/var:5
Yes
organism-sequence


PR:000036417 growth/differentiation factor 5 sequence variant V186* (mouse)
mGDF5/var:V186*
Yes
organism-sequence


PR:P43027-1 growth/differentiation factor 5 isoform 1 (mouse)
mGDF5/iso:1

organism-gene


PR:Q5KSY1 growth and differentiation factor-5 (rat)
rGDF5

sequence


PR:000000436 growth/differentiation factor 5 isoform 1
GDF5/iso:1

organism-sequence


PR:P43026-1 growth/differentiation factor 5 isoform 1 (human)
hGDF5/iso:1
Yes
organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
organism-sequence


PR:P43027-1 growth/differentiation factor 5 isoform 1 (mouse)
mGDF5/iso:1

modification


PR:000021914 growth/differentiation factor 5 isoform 1, signal peptide removed form
GDF5/iso:1/SigPep-

modification


PR:000000640 growth/differentiation factor 5 isoform 1 cleaved 1
GDF5/iso:1/Clv:1

organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human)
hGDF5/iso:1/Clv:1
Yes
modification


PR:000021929 growth/differentiation factor 5 proteolytic cleavage product
GDF5/ClvPrd

gene


PR:000000282 growth/differentiation factor 7
GDF7
Yes
organism-gene


PR:P43029 growth/differentiation factor 7 (mouse)
mGDF7
Yes
organism-sequence


PR:P43029-1 growth/differentiation factor 7 isoform 1 (mouse)
mGDF7/iso:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
mGDF7/iso:1/Clv:1
Yes
organism-sequence


PR:P43029-2 growth/differentiation factor 7 isoform 2 (mouse)
mGDF7/iso:2

organism-gene


PR:Q7Z4P5 growth/differentiation factor 7 (human)
hGDF7

sequence


PR:000000442 growth/differentiation factor 7 isoform 1
GDF7/iso:1

organism-sequence


PR:P43029-1 growth/differentiation factor 7 isoform 1 (mouse)
mGDF7/iso:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
mGDF7/iso:1/Clv:1
Yes
modification


PR:000021915 growth/differentiation factor 7 isoform 1, signal peptide removed form
GDF7/iso:1/SigPep-

modification


PR:000000641 growth/differentiation factor 7 isoform 1 cleaved 1
GDF7/iso:1/Clv:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
mGDF7/iso:1/Clv:1
Yes
sequence


PR:000000443 growth/differentiation factor 7 isoform 2
GDF7/iso:2

organism-sequence


PR:P43029-2 growth/differentiation factor 7 isoform 2 (mouse)
mGDF7/iso:2

modification


PR:000021930 growth/differentiation factor 7 proteolytic cleavage product
GDF7/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000281 GDF5 acts_upstream_of_or_withinGO:0030326 embryonic limb morphogenesis PANTHER:PTHR11848
PR:000000282 GDF7 acts_upstream_of_or_withinGO:0007154 cell communication PANTHER:PTHR11848
PR:000000437 hGDF5/var:C400Y
UniProtKB:P43026, Cys-400, CHEBI:46858		 associated_with_disease_progressionDO:0080052 acromesomelic dysplasia, Grebe type UniProtKB_VAR:VAR_017407
enablesGO:0005515 protein binding with PR:000000164 BMP-2 PMID:9288098
NOT GO:0008083 growth factor activity PMID:9288098
located_inGO:0005622 intracellular anatomical structure PMID:9288098
PR:000000438 hGDF5/var:R438L
UniProtKB:P43026, Arg-438, CHEBI:30006		 associated_with_disease_progressionDO:0050794 multiple synostoses syndrome PMID:16532400
located_inGO:0005615 extracellular space PMID:16532400
PR:000000439 hGDF5/var:L441P
UniProtKB:P43026, Leu-441, CHEBI:50342		 associated_with_disease_progressionDO:0050790 fibular hypoplasia and complex brachydactyly UniProtKB_VAR:VAR_017408
PR:000000441 mGDF5/var:5 associated_with_disease_progressionMP:0006279 abnormal limb development PMID:8145850
PR:000036417 mGDF5/var:V186*
UniProtKB:P43027, 1-185		 associated_with_disease_progressionMP:0006279 abnormal limb development PMID:8145850
located_inSO:0001587 stop_gained PMID:8145850
PR:000036543 hGDF5/iso:1/Clv:1
UniProtKB:P43026-1, 382-501		 enablesGO:0005102 signaling receptor binding PMID:15752764; PMID:15890363
GO:0005515 protein binding PMID:9288098
GO:0008083 growth factor activity PMID:8589725
GO:0042803 protein homodimerization activity PMID:15752764; PMID:8962721
located_inGO:0005615 extracellular space PMID:16532400
PR:000036544 mGDF7/iso:1/Clv:1
UniProtKB:P43029-1, 316-461		 acts_upstream_of_or_withinGO:0007411 axon guidance PMID:12741987
enablesGO:0005515 protein binding with PR:000036516 mBMP7/iso:1/mature PMID:12741987
located_inGO:0005576 extracellular region PMID:12741987
PR:P43026-1 hGDF5/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:7961761
GO:0007267 cell-cell signaling PMID:8589725
PR:P43029 mGDF7 acts_upstream_of_or_withinGO:0045165 cell fate commitment PMID:15883363