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family
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PR:000000098 |
growth/differentiation factor
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FST/iso:2
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"A TGF-beta-like cystine-knot cytokine that is closely related to the BMP family. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release the bioactive C-terminal peptide. GDFs act as signaling molecules during embryonic tendon/ligament formation." [PRO:CNA]
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gene
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PR:000000281 |
growth/differentiation factor 5
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GDF5
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"A growth/differentiation factor that is a translation product of the human GDF5 gene or a 1:1 ortholog thereof." [PRO:CNA]
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Yes |
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organism-gene
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PR:P43026 |
growth/differentiation factor 5 (human)
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hGDF5
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"A growth/differentiation factor 5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P43026]
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organism-sequence
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PR:000000437 |
growth/differentiation factor 5 sequence variant C400Y (human)
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hGDF5/var:C400Y
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"A growth/differentiation factor 5 (human) that has a Tyr residue at the position equivalent to Cys-400 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Cys-400, CHEBI:46858." [PMID:9288098, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:000000438 |
growth/differentiation factor 5 sequence variant R438L (human)
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hGDF5/var:R438L
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"A growth/differentiation factor 5 (human) that has a Leu residue at the position equivalent to Arg-438 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Arg-438, CHEBI:30006." [PMID:16532400, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:000000439 |
growth/differentiation factor 5 sequence variant L441P (human)
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hGDF5/var:L441P
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"A growth/differentiation factor 5 (human) that has a Pro residue at the position equivalent to Leu-441 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Leu-441, CHEBI:50342." [PMID:12121354, PMID:16127465, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:P43026-1 |
growth/differentiation factor 5 isoform 1 (human)
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hGDF5/iso:1
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"A growth/differentiation factor 5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000036543 |
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
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hGDF5/iso:1/Clv:1
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"A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
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Yes |
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organism-modification
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PR:000047523 |
growth/differentiation factor 5, signal peptide removed form (human)
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hGDF5/SigPep-
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"A growth/differentiation factor 5 (human) that has had the signal peptide removed. UniProtKB:P43026, 28-501." [PRO:DNx, Reactome:R-HSA-2396129]
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organism-modification
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PR:000036543 |
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
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hGDF5/iso:1/Clv:1
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"A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
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Yes |
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organism-gene
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PR:P43027 |
growth/differentiation factor 5 (mouse)
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mGDF5
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"A growth/differentiation factor 5 that is encoded in the genome of mouse." [OMA:P43027, PRO:DNx]
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organism-sequence
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PR:000000441 |
growth/differentiation factor 5 sequence variant 5 (mouse)
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mGDF5/var:5
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"A growth/differentiation factor 5 (mouse) that has a frameshift at the position equivalent to residue 376 of the amino acid sequence represented by UniProtKB:P43027." [PMID:8145850, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:000036417 |
growth/differentiation factor 5 sequence variant V186* (mouse)
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mGDF5/var:V186*
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"A growth/differentiation factor 5 (mouse) that has a polypeptide truncation after the position equivalent to residue 185 of the amino acid sequence represented by UniProtKB:P43027. UniProtKB:P43027, 1-185." [PMID:8145850, PRO:CNA]
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Yes |
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organism-sequence
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PR:P43027-1 |
growth/differentiation factor 5 isoform 1 (mouse)
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mGDF5/iso:1
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"A growth/differentiation factor 5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-gene
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PR:Q5KSY1 |
growth and differentiation factor-5 (rat)
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rGDF5
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"A growth/differentiation factor 5 that is encoded in the genome of rat." [PANTHER:PTHR11848:SF44, PRO:DNx]
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sequence
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PR:000000436 |
growth/differentiation factor 5 isoform 1
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GDF5/iso:1
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"A growth/differentiation factor 5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43026-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P43026-1 |
growth/differentiation factor 5 isoform 1 (human)
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hGDF5/iso:1
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"A growth/differentiation factor 5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000036543 |
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
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hGDF5/iso:1/Clv:1
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"A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
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Yes |
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organism-sequence
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PR:P43027-1 |
growth/differentiation factor 5 isoform 1 (mouse)
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mGDF5/iso:1
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"A growth/differentiation factor 5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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modification
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PR:000021914 |
growth/differentiation factor 5 isoform 1, signal peptide removed form
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GDF5/iso:1/SigPep-
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"A growth/differentiation factor 5 isoform 1 that has had the signal peptide removed." [PRO:DNx]
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modification
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PR:000000640 |
growth/differentiation factor 5 isoform 1 cleaved 1
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GDF5/iso:1/Clv:1
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"A growth/differentiation factor 5 isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide, yielding the mature protein. The functional unit is a dimer." [PMID:8962721, PRO:CNA]
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organism-modification
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PR:000036543 |
growth/differentiation factor 5 isoform 1 cleaved 1 (human)
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hGDF5/iso:1/Clv:1
|
"A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]
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Yes |
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modification
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PR:000021929 |
growth/differentiation factor 5 proteolytic cleavage product
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GDF5/ClvPrd
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"A growth/differentiation factor 5 that has been processed by proteolytic cleavage." [PRO:DAN]
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gene
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PR:000000282 |
growth/differentiation factor 7
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GDF7
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"A growth/differentiation factor that is a translation product of the human GDF7 gene or a 1:1 ortholog thereof." [PRO:CNA]
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Yes |
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organism-gene
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PR:P43029 |
growth/differentiation factor 7 (mouse)
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mGDF7
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"A growth/differentiation factor 7 that is encoded in the genome of mouse." [OMA:P43029, PRO:DNx]
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Yes |
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organism-sequence
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PR:P43029-1 |
growth/differentiation factor 7 isoform 1 (mouse)
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mGDF7/iso:1
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"A growth/differentiation factor 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-modification
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PR:000036544 |
growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
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mGDF7/iso:1/Clv:1
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"A growth/differentiation factor 7 isoform 1 cleaved 1 in mouse. UniProtKB:P43029-1, 316-461." [PMID:12741987, PRO:CNA]
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Yes |
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organism-sequence
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PR:P43029-2 |
growth/differentiation factor 7 isoform 2 (mouse)
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mGDF7/iso:2
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"A growth/differentiation factor 7 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
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organism-gene
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PR:Q7Z4P5 |
growth/differentiation factor 7 (human)
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hGDF7
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"A growth/differentiation factor 7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q7Z4P5]
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sequence
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PR:000000442 |
growth/differentiation factor 7 isoform 1
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GDF7/iso:1
|
"A growth/differentiation factor 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43029-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P43029-1 |
growth/differentiation factor 7 isoform 1 (mouse)
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mGDF7/iso:1
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"A growth/differentiation factor 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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organism-modification
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|
PR:000036544 |
growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
|
mGDF7/iso:1/Clv:1
|
"A growth/differentiation factor 7 isoform 1 cleaved 1 in mouse. UniProtKB:P43029-1, 316-461." [PMID:12741987, PRO:CNA]
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Yes |
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modification
|
|
PR:000021915 |
growth/differentiation factor 7 isoform 1, signal peptide removed form
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GDF7/iso:1/SigPep-
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"A growth/differentiation factor 7 isoform 1 that has had the signal peptide removed." [PRO:DNx]
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modification
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PR:000000641 |
growth/differentiation factor 7 isoform 1 cleaved 1
|
GDF7/iso:1/Clv:1
|
"A growth/differentiation factor 7 isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide, yielding the mature protein." [PRO:CNA]
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organism-modification
|
|
PR:000036544 |
growth/differentiation factor 7 isoform 1 cleaved 1 (mouse)
|
mGDF7/iso:1/Clv:1
|
"A growth/differentiation factor 7 isoform 1 cleaved 1 in mouse. UniProtKB:P43029-1, 316-461." [PMID:12741987, PRO:CNA]
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Yes |
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sequence
|
|
PR:000000443 |
growth/differentiation factor 7 isoform 2
|
GDF7/iso:2
|
"A growth/differentiation factor 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P43029-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P43029-2 |
growth/differentiation factor 7 isoform 2 (mouse)
|
mGDF7/iso:2
|
"A growth/differentiation factor 7 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
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modification
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PR:000021930 |
growth/differentiation factor 7 proteolytic cleavage product
|
GDF7/ClvPrd
|
"A growth/differentiation factor 7 that has been processed by proteolytic cleavage." [PRO:DAN]
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