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Protein Ontology report - nodal protein
PR:000000105 - http://purl.obolibrary.org/obo/PR_000000105
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000105   
  PRO namenodal protein 
  Synonyms
PRO-Short-label: EXACT:NODAL
  Definition"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037400
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000105

nodal protein

NODAL


"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]

Yes

organism-gene



PR:P43021

nodal (mouse)

mNODAL


"A nodal protein that is encoded in the genome of mouse." [OMA:P43021, PRO:DNx]


organism-sequence



PR:P43021-1

nodal isoform 1 (mouse)

mNODAL/iso:1


"A nodal protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036469

nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-


"A nodal protein isoform 1, signal peptide removed form in mouse. UniProtKB:P43021-1, 27-354." [PMID:12654299, PMID:15004567, PMID:15649361, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:Q96S42

nodal homolog (human)

hNODAL


"A nodal protein that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96S42]


organism-sequence



PR:000000292

nodal protein sequence variant R183Q (human)

hNODAL/var:R183Q


"A nodal homolog (human) that has a Gln residue at the position equivalent to Arg-183 of the amino acid sequence represented by UniProtKB:Q96S42. UniProtKB:Q96S42, Arg-183, CHEBI:30011." [PMID:9354794, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q96S42-1

nodal homolog isoform 1 (human)

hNODAL/iso:1


"A nodal protein isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000048620

nodal homolog, signal peptide removed form (human)

hNODAL/SigPep-


"A nodal homolog (human) that has had the signal peptide removed. UniProtKB:Q96S42, 27-347." [PRO:DNx, Reactome:R-HSA-1181114]


sequence



PR:000000291

nodal protein isoform 1

NODAL/iso:1


"A nodal protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96S42-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P43021-1

nodal isoform 1 (mouse)

mNODAL/iso:1


"A nodal protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036469

nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-


"A nodal protein isoform 1, signal peptide removed form in mouse. UniProtKB:P43021-1, 27-354." [PMID:12654299, PMID:15004567, PMID:15649361, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q96S42-1

nodal homolog isoform 1 (human)

hNODAL/iso:1


"A nodal protein isoform 1 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000000558

nodal protein isoform 1, signal peptide removed form

NODAL/iso:1/SigPep-


"A nodal protein isoform 1 that has had the signal peptide removed to yield the mature protein." [PRO:CNA]


organism-modification



PR:000036469

nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-


"A nodal protein isoform 1, signal peptide removed form in mouse. UniProtKB:P43021-1, 27-354." [PMID:12654299, PMID:15004567, PMID:15649361, PRO:CNA, PRO:DAN]

Yes

modification



PR:000025433

nodal protein proteolytic cleavage product

NODAL/ClvPrd


"A nodal protein that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007368 determination of left/right symmetryPR:000000105 NODAL PIRSF:PIRSF037400
PR:000036469 mNODAL/iso:1/SigPep- PMID:12654299
PR:P43021-1 mNODAL/iso:1 PMID:12654299
GO:0009952 anterior/posterior pattern specificationPR:000036469 mNODAL/iso:1/SigPep- PMID:15004567
PR:P43021-1 mNODAL/iso:1 PMID:15004567

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050545 visceral heterotaxyPR:000000292 hNODAL/var:R183Q PMID:9354794

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0016015 morphogen activityPR:000000105 NODAL PIRSF:PIRSF037400
GO:0042803 protein homodimerization activityPR:000036469 mNODAL/iso:1/SigPep- PMID:15649361
PR:P43021-1 mNODAL/iso:1 PMID:15649361

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036469 mNODAL/iso:1/SigPep- PMID:15649361
PR:P43021-1 mNODAL/iso:1 PMID:15649361