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Protein Ontology report - nodal protein
PR:000000105 - http://purl.obolibrary.org/obo/PR_000000105
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000105   
  PRO namenodal protein 
  Synonyms
PRO-Short-label: EXACT:NODAL
  Definition"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037400
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000105 nodal protein
NODAL
Yes
organism-gene


PR:P43021 nodal (mouse)
mNODAL

organism-sequence


PR:P43021-1 nodal isoform 1 (mouse)
mNODAL/iso:1
Yes
organism-modification


PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)
mNODAL/iso:1/SigPep-
Yes
organism-gene


PR:Q96S42 nodal homolog (human)
hNODAL

organism-sequence


PR:000000292 nodal protein sequence variant R183Q (human)
hNODAL/var:R183Q
Yes
organism-sequence


PR:Q96S42-1 nodal homolog isoform 1 (human)
hNODAL/iso:1

organism-modification


PR:000048620 nodal homolog, signal peptide removed form (human)
hNODAL/SigPep-

sequence


PR:000000291 nodal protein isoform 1
NODAL/iso:1

organism-sequence


PR:P43021-1 nodal isoform 1 (mouse)
mNODAL/iso:1
Yes
organism-modification


PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)
mNODAL/iso:1/SigPep-
Yes
organism-sequence


PR:Q96S42-1 nodal homolog isoform 1 (human)
hNODAL/iso:1

modification


PR:000000558 nodal protein isoform 1, signal peptide removed form
NODAL/iso:1/SigPep-

organism-modification


PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)
mNODAL/iso:1/SigPep-
Yes
modification


PR:000025433 nodal protein proteolytic cleavage product
NODAL/ClvPrd

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007368 determination of left/right symmetryPR:000000105 NODAL PIRSF:PIRSF037400
PR:000036469 mNODAL/iso:1/SigPep- PMID:12654299
PR:P43021-1 mNODAL/iso:1 PMID:12654299
GO:0009952 anterior/posterior pattern specificationPR:000036469 mNODAL/iso:1/SigPep- PMID:15004567
PR:P43021-1 mNODAL/iso:1 PMID:15004567

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:0050545 visceral heterotaxyPR:000000292 hNODAL/var:R183Q PMID:9354794

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0016015 morphogen activityPR:000000105 NODAL PIRSF:PIRSF037400
GO:0042803 protein homodimerization activityPR:000036469 mNODAL/iso:1/SigPep- PMID:15649361
PR:P43021-1 mNODAL/iso:1 PMID:15649361

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036469 mNODAL/iso:1/SigPep- PMID:15649361
PR:P43021-1 mNODAL/iso:1 PMID:15649361