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Protein Ontology report - Rho-associated protein kinase 1
PR:000000120 - http://purl.obolibrary.org/obo/PR_000000120
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000120   
  PRO nameRho-associated protein kinase 1 
  Synonyms
PRO-Short-label: EXACT:ROCK1
Other: EXACT:p160 ROCK-1 | p160ROCK | renal carcinoma antigen NY-REN-35 | rho-associated, coiled-coil-containing protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase I | ROCK-I
  Definition"A Rho-associated protein kinase that is a translation product of the human ROCK1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000024 Rho-associated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification5                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1503
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000120 Rho-associated protein kinase 1
ROCK1

organism-gene


PR:P70335 Rho-associated protein kinase 1 (mouse)
mROCK1

organism-sequence


PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse)
mROCK1/iso:1

organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
organism-sequence


PR:P70335-2 Rho-associated protein kinase 1 isoform m2 (mouse)
mROCK1/iso:m2

organism-gene


PR:Q13464 Rho-associated protein kinase 1 (human)
hROCK1

organism-sequence


PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human)
hROCK1/iso:1
Yes
organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
organism-modification


PR:000061208 Rho-associated protein kinase 1, initiator methionine removed form (human)
hROCK1/InitMet-

organism-modification


PR:000070060 Rho-associated protein kinase 1 deaminated 1 (human)
hROCK1/Deam:1

organism-modification


PR:000070524 Rho-associated protein kinase 1 phosphorylated 1 (human)
hROCK1/Phos:1

organism-modification


PR:000082399 Rho-associated protein kinase 1 deaminated 2 (human)
hROCK1/Deam:2

organism-gene


PR:Q63644 Rho-associated protein kinase 1 (rat)
rROCK1

organism-sequence


PR:Q63644-1 Rho-associated protein kinase 1 isoform r1 (rat)
rROCK1/iso:r1

organism-sequence


PR:Q63644-2 Rho-associated protein kinase 1 isoform r2 (rat)
rROCK1/iso:r2

sequence


PR:000000307 Rho-associated protein kinase 1 isoform 1
ROCK1/iso:1

organism-sequence


PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse)
mROCK1/iso:1

organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
organism-sequence


PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human)
hROCK1/iso:1
Yes
organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
modification


PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1
ROCK1/iso:1/Clv:1

organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
modification


PR:000002529 Rho-associated protein kinase 1 isoform 1 unmodified form
ROCK1/iso:1/UnMod

organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
modification


PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form
ROCK1/iso:1/InitMet-

modification


PR:000018280 Rho-associated protein kinase 1, initiator methionine removed form
ROCK1/InitMet-

modification


PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form
ROCK1/iso:1/InitMet-

modification


PR:000025435 Rho-associated protein kinase 1 proteolytic cleavage product
ROCK1/ClvPrd

modification


PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1
ROCK1/iso:1/Clv:1

organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026340 hROCK1/iso:1/Clv:1
UniProtKB:Q13464-1, 1-1113		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11283607
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002529 ROCK1/iso:1/UnMod PMID:11283607
PR:000036476 mROCK1/iso:1/Clv:1
UniProtKB:P70335-1, 1-1113		 acts_upstream_of_or_withinGO:0010659 cardiac muscle cell apoptotic process PMID:16983089
GO:0030036 actin cytoskeleton organization PMID:11283607; PMID:16983089
PR:000044586 hROCK1/iso:1/UnMod enablesGO:0004674 protein serine/threonine kinase activity PMID:15699075
GO:0004674 protein serine/threonine kinase activity PMID:15699075
PR:Q13464-1 hROCK1/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:10436159
GO:0007266 Rho protein signal transduction PMID:8798490
GO:0030036 actin cytoskeleton organization PMID:10436159
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:8798490
GO:0031267 small GTPase binding PMID:14660612; PMID:15475352