back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - thrombospondin-1
PR:000000129 - http://purl.obolibrary.org/obo/PR_000000129
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000129   
  PRO namethrombospondin-1 
  Synonyms
PRO-Short-label: EXACT:THBS1
Gene-based: RELATED:TSP | TSP1
Other: EXACT:glycoprotein G
  Definition"A thrombospondin subgroup A that is a translation product of the human THBS1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000029 thrombospondin subgroup A
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification7                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000129 thrombospondin-1
THBS1
Yes
organism-gene


PR:P07996 thrombospondin-1 (human)
hTHBS1

organism-sequence


PR:P07996-1 thrombospondin-1 isoform 1 (human)
hTHBS1/iso:1

organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-sequence


PR:P07996-2 thrombospondin-1 isoform 2 (human)
hTHBS1/iso:2

organism-modification


PR:000028410 thrombospondin-1, signal peptide removed form (human)
hTHBS1/SigPep-
Yes
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000054414 thrombospondin-1 N-glycosylated 1 (human)
hTHBS1/NGlyco:1

organism-modification


PR:000054415 thrombospondin-1 N-glycosylated 2 (human)
hTHBS1/NGlyco:2

organism-modification


PR:000054416 thrombospondin-1 N-glycosylated 3 (human)
hTHBS1/NGlyco:3

organism-modification


PR:000054418 thrombospondin-1 N-glycosylated 5 (human)
hTHBS1/NGlyco:5

organism-modification


PR:000054419 thrombospondin-1 N-glycosylated 6 (human)
hTHBS1/NGlyco:6

organism-modification


PR:000060409 thrombospondin-1, signal peptide removed fucosylserine form (human)
hTHBS1/SigPep-/FucSer+

organism-modification


PR:000064777 thrombospondin-1, signal peptide removed O-glycosylserine form (human)
hTHBS1/SigPep-/OGlycoSer+

organism-modification


PR:000073784 thrombospondin-1 methylated 1 (human)
hTHBS1/Me:1

organism-modification


PR:000076437 thrombospondin-1 deaminated 1 (human)
hTHBS1/Deam:1

organism-modification


PR:000079618 thrombospondin-1 cysteinylated 1 (human)
hTHBS1/Cyst:1

organism-modification


PR:000079709 thrombospondin-1 cysteinylated 2 (human)
hTHBS1/Cyst:2

organism-gene


PR:P35441 thrombospondin-1 (mouse)
mTHBS1

organism-sequence


PR:P35441-1 thrombospondin-1 isoform 1 (mouse)
mTHBS1/iso:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
organism-modification


PR:000044495 thrombospondin-1, signal peptide removed form (mouse)
mTHBS1/SigPep-
Yes
organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
sequence


PR:000000376 thrombospondin-1 isoform 1
THBS1/iso:1

organism-sequence


PR:P07996-1 thrombospondin-1 isoform 1 (human)
hTHBS1/iso:1

organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-sequence


PR:P35441-1 thrombospondin-1 isoform 1 (mouse)
mTHBS1/iso:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
modification


PR:000000587 thrombospondin-1 isoform 1, signal peptide removed form
THBS1/iso:1/SigPep-

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form
THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form
THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000589 thrombospondin-1 isoform 1, signal peptide removed glycosylated form
THBS1/iso:1/SigPep-/GlycoRes+

organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000588 thrombospondin-1 isoform 1 cleaved 2
THBS1/iso:1/Clv:2

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
modification


PR:000018282 thrombospondin-1, signal peptide removed form
THBS1/SigPep-

modification


PR:000000587 thrombospondin-1 isoform 1, signal peptide removed form
THBS1/iso:1/SigPep-

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form
THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form
THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000589 thrombospondin-1 isoform 1, signal peptide removed glycosylated form
THBS1/iso:1/SigPep-/GlycoRes+

organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000028410 thrombospondin-1, signal peptide removed form (human)
hTHBS1/SigPep-
Yes
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000044495 thrombospondin-1, signal peptide removed form (mouse)
mTHBS1/SigPep-
Yes
organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000025437 thrombospondin-1 proteolytic cleavage product
THBS1/ClvPrd

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form
THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form
THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000588 thrombospondin-1 isoform 1 cleaved 2
THBS1/iso:1/Clv:2

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
Back to top
THBS1 forms found in complexes   

THBS1 Component
 Complexes
PR:000028410 hTHBS1/SigPep- PR:000028445 integrin alphaIIbbeta3:thrombospondin 1 (human)
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007596 blood coagulationPR:000000129 THBS1 PANTHER:PTHR10199
GO:0016525 negative regulation of angiogenesisPR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ PMID:17082774
GO:0060055 angiogenesis involved in wound healingPR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ PMID:17082774

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004866 endopeptidase inhibitor activityPR:000026338 hTHBS1/iso:1/SigPep- PMID:8751720
GO:0005515 protein bindingPR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:1459996
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1 PMID:3305519
GO:0042802 identical protein bindingPR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
GO:0050431 transforming growth factor beta bindingPR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:9657149
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1 PMID:15342643

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000026338 hTHBS1/iso:1/SigPep- PMID:15662972
PR:000028410 hTHBS1/SigPep- PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep- PMID:12498716
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:9657149
PR:000044495 mTHBS1/SigPep- PMID:12498716