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Protein Ontology report - bone morphogenetic protein 7
PR:000000168 - http://purl.obolibrary.org/obo/PR_000000168
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000168   
  PRO namebone morphogenetic protein 7 
  Synonyms
PRO-Short-label: EXACT:BMP7
Gene-based: RELATED:OP1
Other: EXACT:BMP-7 | eptotermin alfa | OP-1 | osteogenic protein 1
  Definition"A bone morphogenetic protein that is a translation product of the human BMP7 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000034 bone morphogenetic protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification6                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
gene


PR:000000168
bone morphogenetic protein 7
BMP7
"A bone morphogenetic protein that is a translation product of the human BMP7 gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P18075
bone morphogenetic protein 7 (human)
hBMP7
"A bone morphogenetic protein 7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P18075]

organism-sequence


PR:P18075-1
bone morphogenetic protein 7 isoform 1 (human)
hBMP7/iso:1
"A bone morphogenetic protein 7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036517
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (human)
hBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in human. UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15047707, PMID:15929982, PMID:8570652, PMID:9872992, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036519
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 (human)
hBMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]
Yes
organism-gene


PR:P23359
bone morphogenetic protein 7 (mouse)
mBMP7
"A bone morphogenetic protein 7 that is encoded in the genome of mouse." [OMA:P23359, PRO:DNx]
Yes
organism-sequence


PR:P23359-1
bone morphogenetic protein 7 isoform 1 (mouse)
mBMP7/iso:1
"A bone morphogenetic protein 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036516
bone morphogenetic protein 7 isoform 1, mature form (mouse)
mBMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1, mature form in mouse. UniProtKB:P23359-1, 292-430." [PMID:12741987, PRO:CNA]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
sequence


PR:000000389
bone morphogenetic protein 7 isoform 1
BMP7/iso:1
"A bone morphogenetic protein 7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P18075-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P18075-1
bone morphogenetic protein 7 isoform 1 (human)
hBMP7/iso:1
"A bone morphogenetic protein 7 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036517
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (human)
hBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in human. UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15047707, PMID:15929982, PMID:8570652, PMID:9872992, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036519
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 (human)
hBMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]
Yes
organism-sequence


PR:P23359-1
bone morphogenetic protein 7 isoform 1 (mouse)
mBMP7/iso:1
"A bone morphogenetic protein 7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036516
bone morphogenetic protein 7 isoform 1, mature form (mouse)
mBMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1, mature form in mouse. UniProtKB:P23359-1, 292-430." [PMID:12741987, PRO:CNA]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000612
bone morphogenetic protein 7 isoform 1, mature form
BMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1 that has had the signal peptide and propeptide removed. Example: UniProtKB:P23359-1, 292-430." [PRO:CNA, PRO:DAN]

modification


PR:000000505
bone morphogenetic protein 7 isoform 1, mature glycosylated form
BMP7/iso:1/ClvGlyco+
"A bone morphogenetic protein 7 isoform 1, mature form that includes at least one glycosylated residue." [PRO:CNA, PRO:DAN]

modification


PR:000000613
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1
BMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature glycosylated form that is N-glycosylated at the N{P}[ST]{P} motif. This form is a disulfide linked homodimer. Example: UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]

organism-modification


PR:000036517
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (human)
hBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in human. UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15047707, PMID:15929982, PMID:8570652, PMID:9872992, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000614
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2
BMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature glycosylated form that has the propeptide still bound to the mature protein. This form is N-glycosylated at the most C-terminal N{P}[ST]{P} motif and is a homodimer. Example: UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982]

organism-modification


PR:000036519
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 (human)
hBMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036516
bone morphogenetic protein 7 isoform 1, mature form (mouse)
mBMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1, mature form in mouse. UniProtKB:P23359-1, 292-430." [PMID:12741987, PRO:CNA]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
modification


PR:000021902
bone morphogenetic protein 7 isoform 1, signal peptide removed form
BMP7/iso:1/SigPep-
"A bone morphogenetic protein 7 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000000612
bone morphogenetic protein 7 isoform 1, mature form
BMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1 that has had the signal peptide and propeptide removed. Example: UniProtKB:P23359-1, 292-430." [PRO:CNA, PRO:DAN]

modification


PR:000000505
bone morphogenetic protein 7 isoform 1, mature glycosylated form
BMP7/iso:1/ClvGlyco+
"A bone morphogenetic protein 7 isoform 1, mature form that includes at least one glycosylated residue." [PRO:CNA, PRO:DAN]

modification


PR:000000613
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1
BMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature glycosylated form that is N-glycosylated at the N{P}[ST]{P} motif. This form is a disulfide linked homodimer. Example: UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]

organism-modification


PR:000036517
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (human)
hBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in human. UniProtKB:P18075-1, 293-431, Asn-372, MOD:00160." [PMID:15047707, PMID:15929982, PMID:8570652, PMID:9872992, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000614
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2
BMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature glycosylated form that has the propeptide still bound to the mature protein. This form is N-glycosylated at the most C-terminal N{P}[ST]{P} motif and is a homodimer. Example: UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982]

organism-modification


PR:000036519
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 (human)
hBMP7/iso:1/mature/NGlyco:2
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P18075-1, 20-292, 293-431, Asn-372, MOD:00160." [PMID:15929982, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036516
bone morphogenetic protein 7 isoform 1, mature form (mouse)
mBMP7/iso:1/mature
"A bone morphogenetic protein 7 isoform 1, mature form in mouse. UniProtKB:P23359-1, 292-430." [PMID:12741987, PRO:CNA]
Yes
organism-modification


PR:000036518
bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 (mouse)
mBMP7/iso:1/mature/NGlyco:1
"A bone morphogenetic protein 7 isoform 1, mature N-glycosylated 1 in mouse. UniProtKB:P23359-1, 292-430, Asn-371, MOD:00160." [PMID:14623234, PRO:CNA, PRO:DAN]
Yes
modification


PR:000018288
bone morphogenetic protein 7 proteolytic cleavage product
BMP7/ClvPrd
"A bone morphogenetic protein 7 that has been processed by proteolytic cleavage." [PRO:DNx]

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:P18075-1 hBMP7/iso:1 PMID:2357959
GO:0007411 axon guidancePR:000036516 mBMP7/iso:1/mature PMID:12741987
GO:0007435 salivary gland morphogenesisPR:P23359 mBMP7 PMID:11731698
GO:0009887 animal organ morphogenesisPR:P23359 mBMP7 PMID:7590254
GO:0030509 BMP signaling pathwayPR:000036518 mBMP7/iso:1/mature/NGlyco:1 PMID:14623234
PR:P23359-1 mBMP7/iso:1 PMID:14623234
GO:0035239 tube morphogenesisPR:P23359 mBMP7 PMID:15831470
GO:0042475 odontogenesis of dentin-containing toothPR:P23359 mBMP7 PMID:15525533
GO:0048754 branching morphogenesis of an epithelial tubePR:P23359 mBMP7 PMID:15831470

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036517 hBMP7/iso:1/mature/NGlyco:1 PMID:9872992
NOT GO:0005102 signaling receptor bindingPR:000036519 hBMP7/iso:1/mature/NGlyco:2 PMID:15929982
GO:0005515 protein bindingPR:000036516 mBMP7/iso:1/mature PMID:12741987
PR:P18075-1 hBMP7/iso:1 PMID:12805376
GO:0042803 protein homodimerization activityPR:000036517 hBMP7/iso:1/mature/NGlyco:1 PMID:15929982; PMID:8570652

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036516 mBMP7/iso:1/mature PMID:12741987
PR:000036517 hBMP7/iso:1/mature/NGlyco:1 PMID:15047707; PMID:15929982
PR:000036519 hBMP7/iso:1/mature/NGlyco:2 PMID:15929982
GO:0005794 Golgi apparatusPR:P18075-1 hBMP7/iso:1 PMID:12805376