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Protein Ontology report - TGF-beta 1
PR:000000182 - http://purl.obolibrary.org/obo/PR_000000182
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000182   
  PRO nameTGF-beta 1 
  Synonyms
PRO-Short-label: EXACT:TGFB1
Gene-based: RELATED:TGFB
Other: EXACT:TGF-beta-1
  Definition"A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000046 TGF-beta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification7                                                  Organism-Modification 26                                        
  Term Hierarchy
  Visualization
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000182

TGF-beta 1

TGFB1


"A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P01137

transforming growth factor beta-1 (human)

hTGFB1


"A TGF-beta 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01137]


organism-sequence



PR:000000398

TGF-beta 1 sequence variant L10P (human)

hTGFB1/var:L10P


"A transforming growth factor beta-1 (human) that has a Pro residue at the position equivalent to Leu-10 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Leu-10, CHEBI:50342." [PMID:12202987, PMID:3861940, PMID:9783545, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000399

TGF-beta 1 sequence variant T81H (human)

hTGFB1/var:T81H


"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Tyr-81, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021903

TGF-beta 1 sequence variant T81H, signal peptide removed form (human)

hTGFB1/var:T81H/SigPep-


"A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000619

TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000620

TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000400

TGF-beta 1 sequence variant R218C (human)

hTGFB1/var:R218C


"A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021904

TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

hTGFB1/var:R218C/SigPep-


"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN]


organism-modification



PR:000000621

TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000622

TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000401

TGF-beta 1 sequence variant R218H (human)

hTGFB1/var:R218H


"A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021907

TGF-beta 1 sequence variant R218H, signal peptide removed form (human)

hTGFB1/var:R218H/SigPep-


"A TGF-beta 1 sequence variant R218H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000627

TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000628

TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000402

TGF-beta 1 sequence variant H222D (human)

hTGFB1/var:H222D


"A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021905

TGF-beta 1 sequence variant H222D, signal peptide removed form (human)

hTGFB1/var:H222D/SigPep-


"A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, His-222, CHEBI:29958." [PRO:DNx]


organism-modification



PR:000000623

TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000624

TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000403

TGF-beta 1 sequence variant C225R (human)

hTGFB1/var:C225R


"A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021906

TGF-beta 1 sequence variant C225R, signal peptide removed form (human)

hTGFB1/var:C225R/SigPep-


"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN]


organism-modification



PR:000000625

TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000626

TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P01137-1

transforming growth factor beta-1 isoform 1 (human)

hTGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000025927

TGF-beta 1 isoform 1 mature form (human)

hTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]

Yes

Yes
organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000049430

transforming growth factor beta-1, signal peptide removed form (human)

hTGFB1/SigPep-


"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705]


organism-modification



PR:000021903

TGF-beta 1 sequence variant T81H, signal peptide removed form (human)

hTGFB1/var:T81H/SigPep-


"A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000619

TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000620

TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021904

TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

hTGFB1/var:R218C/SigPep-


"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN]


organism-modification



PR:000000621

TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000622

TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021905

TGF-beta 1 sequence variant H222D, signal peptide removed form (human)

hTGFB1/var:H222D/SigPep-


"A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, His-222, CHEBI:29958." [PRO:DNx]


organism-modification



PR:000000623

TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000624

TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021906

TGF-beta 1 sequence variant C225R, signal peptide removed form (human)

hTGFB1/var:C225R/SigPep-


"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN]


organism-modification



PR:000000625

TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000626

TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021907

TGF-beta 1 sequence variant R218H, signal peptide removed form (human)

hTGFB1/var:R218H/SigPep-


"A TGF-beta 1 sequence variant R218H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000627

TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000628

TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000066327

transforming growth factor beta-1 deaminated 1 (human)

hTGFB1/Deam:1


"A transforming growth factor beta-1 (human) that has been deaminated on the residue at the position equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Asn-176, MOD:00684." [IEDB_epitope:2000821, PRO:DNx]


organism-modification



PR:000069562

transforming growth factor beta-1 cysteinylated 1 (human)

hTGFB1/Cyst:1


"A transforming growth factor beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-387 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-387, MOD:00765." [IEDB_epitope:2123229, PRO:DNx]


organism-gene



PR:P04202

transforming growth factor beta-1 proprotein (mouse)

mTGFB1


"A TGF-beta 1 that is encoded in the genome of mouse." [OMA:P04202, PRO:DNx]


organism-sequence



PR:P04202-1

transforming growth factor beta-1 isoform 1 (mouse)

mTGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000025928

TGF-beta 1 isoform 1 mature form (mouse)

mTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]

Yes

organism-modification



PR:000036529

TGF-beta 1 isoform 1 inactive form (mouse)

mTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:P09533

transforming growth factor beta-1 (green monkey)

GrMonkey-TGFB1


"A TGF-beta 1 that is encoded in the genome of green monkey." [PRO:DAN, UniProtKB:P09533]


organism-sequence



PR:P09533-1

transforming growth factor beta-1 isoform 1 (green monkey)

GrMonkey-TGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of green monkey." [PRO:DAN]


organism-modification



PR:000025930

TGF-beta 1 isoform 1 mature form (green monkey)

GrMonkey-TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]

Yes

organism-modification



PR:000036527

TGF-beta 1 isoform 1 inactive form (green monkey)

GrMonkey-TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:P17246

transforming growth factor beta-1 (rat)

rTGFB1


"A TGF-beta 1 that is encoded in the genome of rat." [OMA:P17246, PRO:DNx]


organism-modification



PR:000025929

TGF-beta 1 isoform 1 mature form (rat)

rTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]

Yes

Yes
organism-gene



PR:Q9VQG9

dawdle, isoform A (fruit fly)

fly-TGFB1


"A TGF-beta 1 that is encoded in the genome of fruit fly." [OMA:Q9VQG9, PRO:CNA]


sequence



PR:000000397

TGF-beta 1 isoform 1

TGFB1/iso:1


"A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01137-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P01137-1

transforming growth factor beta-1 isoform 1 (human)

hTGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000025927

TGF-beta 1 isoform 1 mature form (human)

hTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]

Yes

Yes
organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P04202-1

transforming growth factor beta-1 isoform 1 (mouse)

mTGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000025928

TGF-beta 1 isoform 1 mature form (mouse)

mTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]

Yes

organism-modification



PR:000036529

TGF-beta 1 isoform 1 inactive form (mouse)

mTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P09533-1

transforming growth factor beta-1 isoform 1 (green monkey)

GrMonkey-TGFB1/iso:1


"A TGF-beta 1 isoform 1 that is encoded in the genome of green monkey." [PRO:DAN]


organism-modification



PR:000025930

TGF-beta 1 isoform 1 mature form (green monkey)

GrMonkey-TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]

Yes

organism-modification



PR:000036527

TGF-beta 1 isoform 1 inactive form (green monkey)

GrMonkey-TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000616

TGF-beta 1 isoform 1 mature form

TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025927

TGF-beta 1 isoform 1 mature form (human)

hTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]

Yes

Yes
organism-modification



PR:000025928

TGF-beta 1 isoform 1 mature form (mouse)

mTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]

Yes

organism-modification



PR:000025929

TGF-beta 1 isoform 1 mature form (rat)

rTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]

Yes

Yes
organism-modification



PR:000025930

TGF-beta 1 isoform 1 mature form (green monkey)

GrMonkey-TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]

Yes

modification



PR:000002555

TGF-beta 1 isoform 1 unmodified form

TGFB1/iso:1/UnMod


"A TGF-beta 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


modification



PR:000025454

TGF-beta 1 isoform 1, signal peptide removed form

TGFB1/iso:1/SigPep-


"A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN]


modification



PR:000000617

TGF-beta 1 isoform 1 latency associated peptide

TGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN]


organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000618

TGF-beta 1 isoform 1 inactive form

TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN]


organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036527

TGF-beta 1 isoform 1 inactive form (green monkey)

GrMonkey-TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036529

TGF-beta 1 isoform 1 inactive form (mouse)

mTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]

Yes

modification



PR:000018291

TGF-beta 1, signal peptide removed form

TGFB1/SigPep-


"A TGF-beta 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000025454

TGF-beta 1 isoform 1, signal peptide removed form

TGFB1/iso:1/SigPep-


"A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN]


modification



PR:000000617

TGF-beta 1 isoform 1 latency associated peptide

TGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN]


organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000618

TGF-beta 1 isoform 1 inactive form

TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN]


organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036527

TGF-beta 1 isoform 1 inactive form (green monkey)

GrMonkey-TGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036529

TGF-beta 1 isoform 1 inactive form (mouse)

mTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000049430

transforming growth factor beta-1, signal peptide removed form (human)

hTGFB1/SigPep-


"A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705]


organism-modification



PR:000021903

TGF-beta 1 sequence variant T81H, signal peptide removed form (human)

hTGFB1/var:T81H/SigPep-


"A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000619

TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000620

TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021904

TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

hTGFB1/var:R218C/SigPep-


"A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN]


organism-modification



PR:000000621

TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000622

TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021905

TGF-beta 1 sequence variant H222D, signal peptide removed form (human)

hTGFB1/var:H222D/SigPep-


"A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, His-222, CHEBI:29958." [PRO:DNx]


organism-modification



PR:000000623

TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000624

TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021906

TGF-beta 1 sequence variant C225R, signal peptide removed form (human)

hTGFB1/var:C225R/SigPep-


"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN]


organism-modification



PR:000000625

TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000626

TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000021907

TGF-beta 1 sequence variant R218H, signal peptide removed form (human)

hTGFB1/var:R218H/SigPep-


"A TGF-beta 1 sequence variant R218H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979." [PRO:DAN]


organism-modification



PR:000000627

TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000628

TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000026335

TGF-beta 1 isoform 1 inactive form (human)

hTGFB1/iso:1/inactive


"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]

Yes

organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

modification



PR:000018292

TGF-beta 1 proteolytic cleavage product

TGFB1/ClvPrd


"A TGF-beta 1 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000616

TGF-beta 1 isoform 1 mature form

TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN]


Yes
organism-modification



PR:000025927

TGF-beta 1 isoform 1 mature form (human)

hTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]

Yes

Yes
organism-modification



PR:000025928

TGF-beta 1 isoform 1 mature form (mouse)

mTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]

Yes

organism-modification



PR:000025929

TGF-beta 1 isoform 1 mature form (rat)

rTGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]

Yes

Yes
organism-modification



PR:000025930

TGF-beta 1 isoform 1 mature form (green monkey)

GrMonkey-TGFB1/iso:1/mature


"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]

Yes

modification



PR:000000617

TGF-beta 1 isoform 1 latency associated peptide

TGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN]


organism-modification



PR:000036526

TGF-beta 1 isoform 1 latency associated peptide (human)

hTGFB1/iso:1/LAP


"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000619

TGF-beta 1 sequence variant T81H cleaved 1 (human)

hTGFB1/var:T81H/Clv:1


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000620

TGF-beta 1 sequence variant T81H cleaved 2 (human)

hTGFB1/var:T81H/Clv:2


"A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000621

TGF-beta 1 sequence variant R218C cleaved 1 (human)

hTGFB1/var:R218C/Clv:1


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000622

TGF-beta 1 sequence variant R218C cleaved 2 (human)

hTGFB1/var:R218C/Clv:2


"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000623

TGF-beta 1 sequence variant H222D cleaved 1 (human)

hTGFB1/var:H222D/Clv:1


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000624

TGF-beta 1 sequence variant H222D cleaved 2 (human)

hTGFB1/var:H222D/Clv:2


"A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000625

TGF-beta 1 sequence variant C225R cleaved 1 (human)

hTGFB1/var:C225R/Clv:1


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000626

TGF-beta 1 sequence variant C225R cleaved 2 (human)

hTGFB1/var:C225R/Clv:2


"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000627

TGF-beta 1 sequence variant R218H cleaved 1 (human)

hTGFB1/var:R218H/Clv:1


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000000628

TGF-beta 1 sequence variant R218H cleaved 2 (human)

hTGFB1/var:R218H/Clv:2


"A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN]

Yes

Back to top
TGFB1 forms found in complexes   

TGFB1 Component
Complexes
PR:000000616 TGFB1/iso:1/mature PR:000025925 dimeric TGF-beta 1
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
PR:000025929 rTGFB1/iso:1/mature PR:000025931 dimeric TGF-beta 1 (rat)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000398 hTGFB1/var:L10P PMID:9783545
PR:000000399 hTGFB1/var:T81H PMID:11062463
PR:000000400 hTGFB1/var:R218C PMID:12843182
PR:000000402 hTGFB1/var:H222D PMID:12493741
PR:000000403 hTGFB1/var:C225R PMID:11062463; PMID:12493741; PMID:12843182
PR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
PR:000025927 hTGFB1/iso:1/mature PMID:8471846
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117; PMID:2677679
PR:P01137-1 hTGFB1/iso:1 PMID:1544940
GO:0008283 cell population proliferationPR:000000182 TGFB1 PANTHER:PTHR11848
GO:0030154 cell differentiationPR:000000182 TGFB1 PANTHER:PTHR11848
GO:0030879 mammary gland developmentPR:000025928 mTGFB1/iso:1/mature PMID:1821856
PR:000036529 mTGFB1/iso:1/inactive PMID:1821856
PR:P04202-1 mTGFB1/iso:1 PMID:1821856
GO:0043066 negative regulation of apoptotic processPR:000000400 hTGFB1/var:R218C PMID:11062463; PMID:12493741; PMID:12843182
PR:000000402 hTGFB1/var:H222D PMID:12493741
PR:000000403 hTGFB1/var:C225R PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000025927 hTGFB1/iso:1/mature PMID:9918798
PR:P01137-1 hTGFB1/iso:1 PMID:9918798

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:4997 Camurati-Engelmann diseasePR:000000399 hTGFB1/var:T81H PMID:12493741
PR:000000400 hTGFB1/var:R218C PMID:10973241; PMID:11062463; PMID:12493741; PMID:12843182
PR:000000401 hTGFB1/var:R218H PMID:12493741
PR:000000402 hTGFB1/var:H222D PMID:12493741
PR:000000403 hTGFB1/var:C225R PMID:12493741

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005160 transforming growth factor beta receptor bindingPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11278244
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
PR:000025928 mTGFB1/iso:1/mature PMID:14764882
NOT GO:0005160 transforming growth factor beta receptor bindingPR:000026335 hTGFB1/iso:1/inactive PMID:2677679; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117
GO:0008083 growth factor activityPR:000000400 hTGFB1/var:R218C PMID:11062463; PMID:12493741; PMID:12843182
PR:000000403 hTGFB1/var:C225R PMID:11062463; PMID:12493741; PMID:12843182
PR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000625 hTGFB1/var:C225R/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activityPR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
PR:000025927 hTGFB1/iso:1/mature PMID:3162913; PMID:8471846
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:P01137-1 hTGFB1/iso:1 PMID:1544940

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000000403 hTGFB1/var:C225R PMID:11062463; PMID:12493741; PMID:12843182
PR:000000620 hTGFB1/var:T81H/Clv:2 PMID:12493741
PR:000000621 hTGFB1/var:R218C/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000623 hTGFB1/var:H222D/Clv:1 PMID:12493741
PR:000000625 hTGFB1/var:C225R/Clv:1 PMID:11062463; PMID:12493741; PMID:12843182
PR:000000627 hTGFB1/var:R218H/Clv:1 PMID:11278244
GO:0005796 Golgi lumenPR:P01137-1 hTGFB1/iso:1 PMID:1544940
GO:0031012 extracellular matrixPR:000025927 hTGFB1/iso:1/mature PMID:8294500
PR:000025928 mTGFB1/iso:1/mature PMID:9008713
PR:000025929 rTGFB1/iso:1/mature PMID:11907708
PR:000025930 GrMonkey-TGFB1/iso:1/mature PMID:3185545
PR:000026335 hTGFB1/iso:1/inactive PMID:17015622; PMID:8294500
PR:000036529 mTGFB1/iso:1/inactive PMID:9008713
GO:0032991 protein-containing complexPR:000026335 hTGFB1/iso:1/inactive PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP PMID:17015622; PMID:3162913
PR:000036527 GrMonkey-TGFB1/iso:1/inactive PMID:1448117; PMID:2677679
SO:0001558 polypeptide_localization_variantPR:000000399 hTGFB1/var:T81H PMID:11062463; PMID:12493741
PR:000000619 hTGFB1/var:T81H/Clv:1 PMID:12493741
SO:0001561 polypeptide_partial_loss_of_functionPR:000000622 hTGFB1/var:R218C/Clv:2 PMID:11278244
PR:000000624 hTGFB1/var:H222D/Clv:2 PMID:11278244
PR:000000626 hTGFB1/var:C225R/Clv:2 PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244
SO:0001601 conformational_change_variantPR:000000624 hTGFB1/var:H222D/Clv:2 PMID:11278244
PR:000000628 hTGFB1/var:R218H/Clv:2 PMID:11278244