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Protein Ontology report - activin receptor type-1B isoform 1
PR:000000201 - http://purl.obolibrary.org/obo/PR_000000201
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000201   
  PRO nameactivin receptor type-1B isoform 1 
  Synonyms
PRO-Short-label: EXACT:ACVR1B/iso:1
Other: RELATED:Alk4-1 | SKR2-1
  Definition"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000068 activin receptor type-1B
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
sequence



PR:000000201

activin receptor type-1B isoform 1

ACVR1B/iso:1


"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P36896-1

activin receptor type-1B isoform 1 (human)

hACVR1B/iso:1


"An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036437

activin receptor type-1B isoform 1 phosphorylated 1 (human)

hACVR1B/iso:1/Phos:1


"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]

Yes

organism-modification



PR:000036438

activin receptor type-1B isoform 1 phosphorylated 2 (human)

hACVR1B/iso:1/Phos:2


"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]


organism-sequence



PR:Q61271-1

activin receptor type-1B isoform 1 (mouse)

mACVR1B/iso:1


"An activin receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000412

activin receptor type-1B isoform 1 phosphorylated form

ACVR1B/iso:1/PhosRes+


"An activin receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000525

activin receptor type-1B isoform 1 phosphorylated 1

ACVR1B/iso:1/Phos:1


"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated at Ser/Thr residues in the GS-motif region (GSGSGLP and surrounding sequence) by activated activin receptor type-2, and constitutes an active receptor subunit." [PMID:8622651, PMID:8721982, PRO:CNA]


organism-modification



PR:000036437

activin receptor type-1B isoform 1 phosphorylated 1 (human)

hACVR1B/iso:1/Phos:1


"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]

Yes

modification



PR:000000526

activin receptor type-1B isoform 1 phosphorylated 2

ACVR1B/iso:1/Phos:2


"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated on a Tyr residue within the protein kinase domain, as a result of platelet activation. Example: UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA, PRO:DAN]


organism-modification



PR:000036438

activin receptor type-1B isoform 1 phosphorylated 2 (human)

hACVR1B/iso:1/Phos:2


"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036437 hACVR1B/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
enablesGO:0016361 activin receptor activity, type I PMID:8622651
GO:0046332 SMAD binding PMID:12065756
located_inGO:0005886 plasma membrane PMID:8397373
GO:0009986 cell surface PMID:12665502
PR:P36896-1 hACVR1B/iso:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:11069203