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Protein Ontology report - fungal/metazoan cullin-1 isoform 1
PR:000000267 - http://purl.obolibrary.org/obo/PR_000000267
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000267   
  PRO namefungal/metazoan cullin-1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:CUL1/iso:1
  Definition"A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13616-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000000092 fungal/metazoan cullin-1
  TaxonNCBITaxon:33154 Opisthokonta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

comp. In Complex?
sequence


PR:000000267
fungal/metazoan cullin-1 isoform 1
CUL1/iso:1
"A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13616-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q13616-1
cullin-1 isoform 1 (human)
hCUL1/iso:1
"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036454
cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]
Yes
organism-sequence


PR:Q9WTX6-1
cullin-1 isoform 1 (mouse)
mCUL1/iso:1
"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000000427
fungal/metazoan cullin-1 isoform 1 neddylated form
CUL1/iso:1/NeddLys+
"A fungal/metazoan cullin-1 isoform 1 that includes at least one neddylated lysine." [PRO:CNA]

modification


PR:000000542
fungal/metazoan cullin-1 isoform 1 neddylated 1
CUL1/iso:1/Nedd:1
"A fungal/metazoan cullin-1 isoform 1 neddylated form that has been neddylated in the conserved Lys residue within the IVR[ILV]MKxR[RK] motif. Example: UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156]

organism-modification


PR:000036454
cullin-1 isoform 1 neddylated 1 (human)
hCUL1/iso:1/Nedd:1
"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0008285 negative regulation of cell population proliferationPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processPR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cyclePR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathwayPR:000036454 hCUL1/iso:1/Nedd:1 PMID:8681378

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005515 protein bindingPR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541
PR:Q13616-1 hCUL1/iso:1 PMID:12504026; PMID:15537541

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0019005 SCF ubiquitin ligase complexPR:000036454 hCUL1/iso:1/Nedd:1 PMID:10713156; PMID:10921923; PMID:17098746
NOT GO:0019005 SCF ubiquitin ligase complexPR:Q13616-1 hCUL1/iso:1 PMID:10713156; PMID:10921923; PMID:12504026