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Protein Ontology report - tumor necrosis factor ligand superfamily member 6 isoform FasL
PR:000000276 -
http://purl.obolibrary.org/obo/PR_000000276
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000276
PRO name
tumor necrosis factor ligand superfamily member 6 isoform FasL
Synonyms
PRO-Short-label
:
EXACT:
FASLG/iso:FasL
Other
:
EXACT:
tumor necrosis factor ligand superfamily member 6 isoform 1
RELATED:
FasL long
Definition
"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:P48023-1
or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
PRO Category
sequence
Parent
PR:000000095
tumor necrosis factor ligand superfamily member 6
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
2
Organism-Sequence
4
Modification
3
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
comp.
In Complex?
sequence
PR:000000276
tumor necrosis factor ligand superfamily member 6 isoform FasL
FASLG/iso:FasL
sequence
PR:000000278
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L
FASLG/iso:FasL/var:F273L
organism-sequence
PR:000036782
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-sequence
PR:000036783
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence
PR:P41047-1
tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)
mFASLG/iso:FasL
Yes
organism-sequence
PR:000036783
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence
PR:P48023-1
tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence
PR:000036782
tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification
PR:000036458
tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification
PR:000036459
tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
modification
PR:000000432
tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form
FASLG/iso:FasL/GlycoRes+
modification
PR:000000546
tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1
FASLG/iso:FasL/NGlyco:1
organism-modification
PR:000036458
tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
modification
PR:000000547
tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form
FASLG/iso:FasL/Clv:soluble
organism-modification
PR:000036459
tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000036458
hFASLG/iso:FasL/NGlyco:1
UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160
acts_upstream_of_or_within
GO:0097190
apoptotic signaling pathway
PMID:9405425
enables
GO:0005102
signaling receptor binding
PMID:9405425
PR:000036459
hFASLG/iso:FasL/Clv:soluble
UniProtKB:P48023-1, 130-281
acts_upstream_of_or_within
GO:0043066
negative regulation of apoptotic process
PMID:9396774
enables
GO:0005102
signaling receptor binding
PMID:9405425
GO:0042802
identical protein binding
PMID:7536672
;
PMID:9228058
;
PMID:9405425
located_in
GO:0005615
extracellular space
PMID:7536672
PR:000036782
hFASLG/iso:FasL/var:F273L
UniProtKB:P48023-1, Phe-275, CHEBI:30006
enables
altered
GO:0005102
signaling receptor binding
with
PR:P25445
apo-1 antigen (human)
PMID:9405425
GO:0042802
identical protein binding
PMID:9405425
located_in
GO:0009986
cell surface
PMID:9405425
PR:000036783
mFASLG/iso:FasL/var:F273L
UniProtKB:P41047-1, Phe-273, CHEBI:30006
associated_with_disease_progression
DO:6688
autoimmune lymphoproliferative syndrome
PMID:7495745
located_in
GO:0005886
plasma membrane
PMID:7495745
PR:P41047-1
mFASLG/iso:FasL
acts_upstream_of_or_within
GO:0006915
apoptotic process
PMID:16365167
GO:0043066
negative regulation of apoptotic process
MGI_ref:76989;
PMID:7595210
GO:0097190
apoptotic signaling pathway
PMID:15039234
located_in
GO:0005886
plasma membrane
PMID:16973387
GO:0009986
cell surface
PMID:16973387
PR:P48023-1
hFASLG/iso:FasL
acts_upstream_of_or_within
GO:0043123
positive regulation of canonical NF-kappaB signal transduction
PMID:12761501
