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Protein Ontology report - smad3
PR:000000365 - http://purl.obolibrary.org/obo/PR_000000365
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000365   
  PRO namesmad3 
  Synonyms
PRO-Short-label: EXACT:SMAD3
Gene-based: RELATED:MADH3
Other: EXACT:JV15-2 | MAD homolog 3 | MAD-3 | mad3 | mothers against DPP homolog 3 | SMAD 3 | SMAD family member 3
  Definition"A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995
  PRO Categorygene 
  ParentPR:000000066 TGF-beta receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification6                                                  Organism-Modification 18                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

comp. In Complex?
gene



PR:000000365

smad3

SMAD3


"A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995]


organism-gene



PR:P84022

mothers against decapentaplegic homolog 3 (human)

hSMAD3


"A smad3 that is encoded in the genome of human." []


organism-sequence



PR:000062539

mothers against decapentaplegic homolog 3 sequence variant S425F (human)

hSMAD3/var:S425F


"A mothers against decapentaplegic homolog 3 (human) that has a Phe residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-8944158]


organism-sequence



PR:000063486

mothers against decapentaplegic homolog 3 sequence variant S425C (human)

hSMAD3/var:S425C


"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3308499]


organism-sequence



PR:P84022-1

mothers against decapentaplegic homolog 3 isoform 1 (human)

hSMAD3/iso:1


"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026333

smad3 isoform 1 phosphorylated 1 (human)

hSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]

Yes

organism-modification



PR:000036557

smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

organism-sequence



PR:P84022-2

mothers against decapentaplegic homolog 3 isoform h2 (human)

hSMAD3/iso:h2


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-2." [PRO:DNx, UniProtKB:P84022]


organism-sequence



PR:P84022-3

mothers against decapentaplegic homolog 3 isoform h3 (human)

hSMAD3/iso:h3


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-3." [PRO:DNx, UniProtKB:P84022]


organism-sequence



PR:P84022-4

mothers against decapentaplegic homolog 3 isoform h4 (human)

hSMAD3/iso:h4


"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-4." [PRO:DNx, UniProtKB:P84022]


organism-modification



PR:000049285

mothers against decapentaplegic homolog 3 phosphorylated 1 (human)

hSMAD3/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-171184, Reactome:R-HSA-177104]


organism-modification



PR:000049286

mothers against decapentaplegic homolog 3 phosphorylated 2 (human)

hSMAD3/Phos:2


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-179, and phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2176471]


organism-modification



PR:000049287

mothers against decapentaplegic homolog 3 ubiquitinated form (human)

hSMAD3/UbiqLys+


"A mothers against decapentaplegic homolog 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:P84022, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782830]


organism-modification



PR:000064859

mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human)

hSMAD3/PhosUbiq:1


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-179, Ser-423, and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:P84022-1, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773841]


organism-modification



PR:000060563

mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human)

hSMAD3/var:R268H/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has a His residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29979|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315080]


organism-modification



PR:000061858

mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)

hSMAD3/ADPribPhos:1


"A mothers against decapentaplegic homolog 3 (human) that has been ADP-ribosylated on the residues at the positions equivalent to Glu-50 and Glu-52 and phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2187326]


organism-modification



PR:000063368

mothers against decapentaplegic homolog 3 phosphorylated 3 (human)

hSMAD3/Phos:3


"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-208 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-208, MOD:00046." [PRO:DNx, Reactome:R-HSA-9731114]


organism-modification



PR:000063580

mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human)

hSMAD3/var:R268C/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29950|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315075]


organism-modification



PR:000063639

mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human)

hSMAD3/var:D258N/Phos:1


"A mothers against decapentaplegic homolog 3 (human) that has an Asn residue at the position equivalent to Asp-258 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Asp-258, CHEBI:50347|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315470]


organism-modification



PR:000065228

mothers against decapentaplegic homolog 3 deaminated 1 (human)

hSMAD3/Deam:1


"A mothers against decapentaplegic homolog 3 (human) that has been deaminated on the residue at the position equivalent to Asn-24 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Asn-24, MOD:00684." [IEDB_epitope:1979961, PRO:DNx]


organism-modification



PR:000065534

mothers against decapentaplegic homolog 3 methylated 1 (human)

hSMAD3/Me:1


"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00660." [IEDB_epitope:1004379, PRO:DNx]


organism-modification



PR:000073148

mothers against decapentaplegic homolog 3 cysteinylated 1 (human)

hSMAD3/Cyst:1


"A mothers against decapentaplegic homolog 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00765." [IEDB_epitope:925064, PRO:DNx]


organism-modification



PR:000074741

mothers against decapentaplegic homolog 3 methylated 2 (human)

hSMAD3/Me:2


"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-320 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-320, MOD:00660." [IEDB_epitope:1059096, PRO:DNx]


organism-gene



PR:P84023

mothers against decapentaplegic homolog 3 (chicken)

chick-SMAD3


"A smad3 that is encoded in the genome of chicken." [OMA:P84023, PRO:DNx]


organism-gene



PR:P84025

mothers against decapentaplegic homolog 3 (rat)

rSMAD3


"A smad3 that is encoded in the genome of rat." [OMA:P84025, PRO:DNx]


organism-gene



PR:Q8BUN5

mothers against decapentaplegic homolog 3 (mouse)

mSMAD3


"A smad3 that is encoded in the genome of mouse." [OMA:Q8BUN5, PRO:DNx]


organism-sequence



PR:Q8BUN5-1

mothers against decapentaplegic homolog 3 isoform 1 (mouse)

mSMAD3/iso:1


"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036558

smad3 isoform 1 phosphorylated 1 (mouse)

mSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]

Yes

organism-modification



PR:000036560

smad3 isoform 1 phosphorylated 2 (mouse)

mSMAD3/iso:1/Phos:2


"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036561

smad3 isoform 1 phosphorylated 3 (mouse)

mSMAD3/iso:1/Phos:3


"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]

Yes

sequence



PR:000000475

smad3 isoform 1

SMAD3/iso:1


"A smad3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P84022-1

mothers against decapentaplegic homolog 3 isoform 1 (human)

hSMAD3/iso:1


"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026333

smad3 isoform 1 phosphorylated 1 (human)

hSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]

Yes

organism-modification



PR:000036557

smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

organism-sequence



PR:Q8BUN5-1

mothers against decapentaplegic homolog 3 isoform 1 (mouse)

mSMAD3/iso:1


"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036558

smad3 isoform 1 phosphorylated 1 (mouse)

mSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]

Yes

organism-modification



PR:000036560

smad3 isoform 1 phosphorylated 2 (mouse)

mSMAD3/iso:1/Phos:2


"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036561

smad3 isoform 1 phosphorylated 3 (mouse)

mSMAD3/iso:1/Phos:3


"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000577

smad3 isoform 1 acetylated and phosphorylated form

SMAD3/iso:1/AcPhos+


"A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000657

smad3 isoform 1 acetylated and phosphorylated 1

SMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756]


organism-modification



PR:000036557

smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

modification



PR:000000578

smad3 isoform 1 phosphorylated form

SMAD3/iso:1/PhosRes+


"A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000577

smad3 isoform 1 acetylated and phosphorylated form

SMAD3/iso:1/AcPhos+


"A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000657

smad3 isoform 1 acetylated and phosphorylated 1

SMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756]


organism-modification



PR:000036557

smad3 isoform 1 acetylated and phosphorylated 1 (human)

hSMAD3/iso:1/AcPhos:1


"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

modification



PR:000000658

smad3 isoform 1 phosphorylated 1

SMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PMID:8774881]


organism-modification



PR:000026333

smad3 isoform 1 phosphorylated 1 (human)

hSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]

Yes

organism-modification



PR:000036558

smad3 isoform 1 phosphorylated 1 (mouse)

mSMAD3/iso:1/Phos:1


"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]

Yes

modification



PR:000000659

smad3 isoform 1 phosphorylated 2

SMAD3/iso:1/Phos:2


"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]


organism-modification



PR:000036560

smad3 isoform 1 phosphorylated 2 (mouse)

mSMAD3/iso:1/Phos:2


"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000660

smad3 isoform 1 phosphorylated 3

SMAD3/iso:1/Phos:3


"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in oncogenic Ras-activated pathway. Example: UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]


organism-modification



PR:000036561

smad3 isoform 1 phosphorylated 3 (mouse)

mSMAD3/iso:1/Phos:3


"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026333 hSMAD3/iso:1/Phos:1
UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046
acts_upstream_of_or_withinGO:0006366 transcription by RNA polymerase II PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881; PMID:9380693
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15084259
GO:0046332 SMAD binding PMID:15350224; PMID:9311995
located_inGO:0005634 nucleus PMID:10846168; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
PR:000036557 hSMAD3/iso:1/AcPhos:1
UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003700 DNA-binding transcription factor activity PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1
UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046
enablesGO:0003690 double-stranded DNA binding PMID:15282343
GO:0003700 DNA-binding transcription factor activity PMID:10823886; PMID:12943993
GO:0008134 transcription factor binding PMID:15464984; PMID:9702197
located_inGO:0005634 nucleus PMID:12943993; PMID:15282343
GO:0005667 transcription factor complex PMID:9702197
PR:000036560 mSMAD3/iso:1/Phos:2
UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046
enablesdecreased GO:0003700 DNA-binding transcription factor activity relative to PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15241418
PR:000036561 mSMAD3/iso:1/Phos:3
UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046
enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:P84022-1 hSMAD3/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8774881
enablesGO:0005515 protein binding with PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:O95405-1 PMID:12154125
located_inGO:0005737 cytoplasm PMID:17074053
PR:Q8BUN5-1 mSMAD3/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12543979
enablesGO:0005515 protein binding with PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12154125
GO:0005515 protein binding with PR:A2A8R0 mZFYVE9/iso:1 PMID:12154125