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gene
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PR:000000365 |
smad3
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SMAD3
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"A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995]
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organism-gene
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PR:P84022 |
mothers against decapentaplegic homolog 3 (human)
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hSMAD3
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"A smad3 that is encoded in the genome of human." []
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organism-sequence
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PR:000062539 |
mothers against decapentaplegic homolog 3 sequence variant S425F (human)
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hSMAD3/var:S425F
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"A mothers against decapentaplegic homolog 3 (human) that has a Phe residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-8944158]
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organism-sequence
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PR:000063486 |
mothers against decapentaplegic homolog 3 sequence variant S425C (human)
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hSMAD3/var:S425C
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"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-425, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-3308499]
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organism-sequence
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PR:P84022-1 |
mothers against decapentaplegic homolog 3 isoform 1 (human)
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hSMAD3/iso:1
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"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000026333 |
smad3 isoform 1 phosphorylated 1 (human)
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hSMAD3/iso:1/Phos:1
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"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]
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Yes |
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organism-modification
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PR:000036557 |
smad3 isoform 1 acetylated and phosphorylated 1 (human)
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hSMAD3/iso:1/AcPhos:1
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"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
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Yes |
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organism-sequence
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PR:P84022-2 |
mothers against decapentaplegic homolog 3 isoform h2 (human)
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hSMAD3/iso:h2
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"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-2." [PRO:DNx, UniProtKB:P84022]
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organism-sequence
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PR:P84022-3 |
mothers against decapentaplegic homolog 3 isoform h3 (human)
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hSMAD3/iso:h3
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"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-3." [PRO:DNx, UniProtKB:P84022]
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organism-sequence
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PR:P84022-4 |
mothers against decapentaplegic homolog 3 isoform h4 (human)
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hSMAD3/iso:h4
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"A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-4." [PRO:DNx, UniProtKB:P84022]
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organism-modification
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PR:000049285 |
mothers against decapentaplegic homolog 3 phosphorylated 1 (human)
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hSMAD3/Phos:1
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"A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-171184, Reactome:R-HSA-177104]
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organism-modification
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PR:000049286 |
mothers against decapentaplegic homolog 3 phosphorylated 2 (human)
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hSMAD3/Phos:2
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"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-179, and phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2176471]
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organism-modification
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PR:000049287 |
mothers against decapentaplegic homolog 3 ubiquitinated form (human)
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hSMAD3/UbiqLys+
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"A mothers against decapentaplegic homolog 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:P84022, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782830]
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organism-modification
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PR:000064859 |
mothers against decapentaplegic homolog 3 phosphorylated and ubiquitinated 1 (human)
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hSMAD3/PhosUbiq:1
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"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-179, Ser-423, and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1 and that includes at least 1 ubiquitinated lysine. Example: UniProtKB:P84022-1, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046|MOD:01148." [PRO:DNx, Reactome:R-HSA-9773841]
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organism-modification
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PR:000060563 |
mothers against decapentaplegic homolog 3 sequence variant R268H phosphorylated 1 (human)
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hSMAD3/var:R268H/Phos:1
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"A mothers against decapentaplegic homolog 3 (human) that has a His residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29979|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315080]
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organism-modification
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PR:000061858 |
mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)
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hSMAD3/ADPribPhos:1
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"A mothers against decapentaplegic homolog 3 (human) that has been ADP-ribosylated on the residues at the positions equivalent to Glu-50 and Glu-52 and phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2187326]
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organism-modification
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PR:000063368 |
mothers against decapentaplegic homolog 3 phosphorylated 3 (human)
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hSMAD3/Phos:3
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"A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-208 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Ser-208, MOD:00046." [PRO:DNx, Reactome:R-HSA-9731114]
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organism-modification
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PR:000063580 |
mothers against decapentaplegic homolog 3 sequence variant R268C phosphorylated 1 (human)
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hSMAD3/var:R268C/Phos:1
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"A mothers against decapentaplegic homolog 3 (human) that has a Cys residue at the position equivalent to Arg-268 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Arg-268, CHEBI:29950|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315075]
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organism-modification
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PR:000063639 |
mothers against decapentaplegic homolog 3 sequence variant D258N phosphorylated 1 (human)
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hSMAD3/var:D258N/Phos:1
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"A mothers against decapentaplegic homolog 3 (human) that has an Asn residue at the position equivalent to Asp-258 of the amino acid sequence represented by UniProtKB:P84022-1 and that has been phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425. Example: UniProtKB:P84022-1, Asp-258, CHEBI:50347|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-3315470]
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organism-modification
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PR:000065228 |
mothers against decapentaplegic homolog 3 deaminated 1 (human)
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hSMAD3/Deam:1
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"A mothers against decapentaplegic homolog 3 (human) that has been deaminated on the residue at the position equivalent to Asn-24 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Asn-24, MOD:00684." [IEDB_epitope:1979961, PRO:DNx]
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organism-modification
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PR:000065534 |
mothers against decapentaplegic homolog 3 methylated 1 (human)
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hSMAD3/Me:1
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"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00660." [IEDB_epitope:1004379, PRO:DNx]
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organism-modification
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PR:000073148 |
mothers against decapentaplegic homolog 3 cysteinylated 1 (human)
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hSMAD3/Cyst:1
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"A mothers against decapentaplegic homolog 3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-121 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-121, MOD:00765." [IEDB_epitope:925064, PRO:DNx]
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organism-modification
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PR:000074741 |
mothers against decapentaplegic homolog 3 methylated 2 (human)
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hSMAD3/Me:2
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"A mothers against decapentaplegic homolog 3 (human) that has been methylated on the residue at the position equivalent to Cys-320 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Cys-320, MOD:00660." [IEDB_epitope:1059096, PRO:DNx]
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organism-gene
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PR:P84023 |
mothers against decapentaplegic homolog 3 (chicken)
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chick-SMAD3
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"A smad3 that is encoded in the genome of chicken." [OMA:P84023, PRO:DNx]
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organism-gene
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PR:P84025 |
mothers against decapentaplegic homolog 3 (rat)
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rSMAD3
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"A smad3 that is encoded in the genome of rat." [OMA:P84025, PRO:DNx]
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organism-gene
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PR:Q8BUN5 |
mothers against decapentaplegic homolog 3 (mouse)
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mSMAD3
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"A smad3 that is encoded in the genome of mouse." [OMA:Q8BUN5, PRO:DNx]
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organism-sequence
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PR:Q8BUN5-1 |
mothers against decapentaplegic homolog 3 isoform 1 (mouse)
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mSMAD3/iso:1
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"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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organism-modification
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PR:000036558 |
smad3 isoform 1 phosphorylated 1 (mouse)
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mSMAD3/iso:1/Phos:1
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"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]
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Yes |
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organism-modification
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PR:000036560 |
smad3 isoform 1 phosphorylated 2 (mouse)
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mSMAD3/iso:1/Phos:2
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"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
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Yes |
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organism-modification
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PR:000036561 |
smad3 isoform 1 phosphorylated 3 (mouse)
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mSMAD3/iso:1/Phos:3
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"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
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Yes |
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sequence
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PR:000000475 |
smad3 isoform 1
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SMAD3/iso:1
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"A smad3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:P84022-1 |
mothers against decapentaplegic homolog 3 isoform 1 (human)
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hSMAD3/iso:1
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"A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
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PR:000026333 |
smad3 isoform 1 phosphorylated 1 (human)
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hSMAD3/iso:1/Phos:1
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"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]
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Yes |
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organism-modification
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PR:000036557 |
smad3 isoform 1 acetylated and phosphorylated 1 (human)
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hSMAD3/iso:1/AcPhos:1
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"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
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Yes |
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organism-sequence
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PR:Q8BUN5-1 |
mothers against decapentaplegic homolog 3 isoform 1 (mouse)
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mSMAD3/iso:1
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"A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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organism-modification
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PR:000036558 |
smad3 isoform 1 phosphorylated 1 (mouse)
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mSMAD3/iso:1/Phos:1
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"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]
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Yes |
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organism-modification
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PR:000036560 |
smad3 isoform 1 phosphorylated 2 (mouse)
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mSMAD3/iso:1/Phos:2
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"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
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Yes |
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organism-modification
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PR:000036561 |
smad3 isoform 1 phosphorylated 3 (mouse)
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mSMAD3/iso:1/Phos:3
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"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
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Yes |
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modification
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PR:000000577 |
smad3 isoform 1 acetylated and phosphorylated form
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SMAD3/iso:1/AcPhos+
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"A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]
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modification
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PR:000000657 |
smad3 isoform 1 acetylated and phosphorylated 1
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SMAD3/iso:1/AcPhos:1
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"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756]
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organism-modification
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PR:000036557 |
smad3 isoform 1 acetylated and phosphorylated 1 (human)
|
hSMAD3/iso:1/AcPhos:1
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"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
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Yes |
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modification
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PR:000000578 |
smad3 isoform 1 phosphorylated form
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SMAD3/iso:1/PhosRes+
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"A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
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modification
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PR:000000577 |
smad3 isoform 1 acetylated and phosphorylated form
|
SMAD3/iso:1/AcPhos+
|
"A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]
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modification
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PR:000000657 |
smad3 isoform 1 acetylated and phosphorylated 1
|
SMAD3/iso:1/AcPhos:1
|
"A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756]
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organism-modification
|
|
PR:000036557 |
smad3 isoform 1 acetylated and phosphorylated 1 (human)
|
hSMAD3/iso:1/AcPhos:1
|
"A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA]
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Yes |
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modification
|
|
PR:000000658 |
smad3 isoform 1 phosphorylated 1
|
SMAD3/iso:1/Phos:1
|
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PMID:8774881]
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organism-modification
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|
PR:000026333 |
smad3 isoform 1 phosphorylated 1 (human)
|
hSMAD3/iso:1/Phos:1
|
"A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022]
|
Yes |
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organism-modification
|
|
PR:000036558 |
smad3 isoform 1 phosphorylated 1 (mouse)
|
mSMAD3/iso:1/Phos:1
|
"A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA]
|
Yes |
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modification
|
|
PR:000000659 |
smad3 isoform 1 phosphorylated 2
|
SMAD3/iso:1/Phos:2
|
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
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organism-modification
|
|
PR:000036560 |
smad3 isoform 1 phosphorylated 2 (mouse)
|
mSMAD3/iso:1/Phos:2
|
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
|
Yes |
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| | |
modification
|
|
PR:000000660 |
smad3 isoform 1 phosphorylated 3
|
SMAD3/iso:1/Phos:3
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"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in oncogenic Ras-activated pathway. Example: UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
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organism-modification
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PR:000036561 |
smad3 isoform 1 phosphorylated 3 (mouse)
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mSMAD3/iso:1/Phos:3
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"A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN]
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Yes |
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