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Protein Ontology report - thrombospondin-1 isoform 1
PR:000000376 - http://purl.obolibrary.org/obo/PR_000000376
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000376   
  PRO namethrombospondin-1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:THBS1/iso:1
  Definition"A thrombospondin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P07996-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000129 thrombospondin-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

comp. In Complex?
sequence


PR:000000376 thrombospondin-1 isoform 1
THBS1/iso:1

organism-sequence


PR:P07996-1 thrombospondin-1 isoform 1 (human)
hTHBS1/iso:1

organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-sequence


PR:P35441-1 thrombospondin-1 isoform 1 (mouse)
mTHBS1/iso:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
modification


PR:000000587 thrombospondin-1 isoform 1, signal peptide removed form
THBS1/iso:1/SigPep-

modification


PR:000000485 thrombospondin-1 isoform 1 cleaved and glycosylated form
THBS1/iso:1/ClvGlyco+

modification


PR:000000590 thrombospondin-1 isoform 1 cleaved 2 glycosylated form
THBS1/iso:1/Clv:2/GlycoRes+

organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000589 thrombospondin-1 isoform 1, signal peptide removed glycosylated form
THBS1/iso:1/SigPep-/GlycoRes+

organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000026338 thrombospondin-1 isoform 1, signal peptide removed form (human)
hTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036488 thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)
hTHBS1/iso:1/SigPep-/Glyco:1
Yes
organism-modification


PR:000036489 thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)
hTHBS1/iso:1/Clv:2/Glyco:1

organism-modification


PR:000036485 thrombospondin-1 isoform 1, signal peptide removed form (mouse)
mTHBS1/iso:1/SigPep-
Yes
organism-modification


PR:000036487 thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)
mTHBS1/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036490 thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)
mTHBS1/iso:1/Clv:2/GlycoRes+
Yes
modification


PR:000000588 thrombospondin-1 isoform 1 cleaved 2
THBS1/iso:1/Clv:2

organism-modification


PR:000028966 thrombospondin-1 isoform 1 cleaved 2 (human)
hTHBS1/iso:1/Clv:2

organism-modification


PR:000036486 thrombospondin-1 isoform 1 cleaved 2 (mouse)
mTHBS1/iso:1/Clv:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026338 hTHBS1/iso:1/SigPep-
UniProtKB:P07996-1, 19-1170		 enablesGO:0004866 endopeptidase inhibitor activity PMID:8751720
located_inGO:0005615 extracellular space PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep-
UniProtKB:P35441-1, 19-1170		 located_inGO:0005615 extracellular space PMID:12498716
PR:000036486 mTHBS1/iso:1/Clv:2
UniProtKB:P35441-1, 19-311		 acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774
enablesGO:0042802 identical protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:17082774
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+
UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813		 enablesGO:0005515 protein binding with PR:000036486 mTHBS1/iso:1/Clv:2 PMID:1459996
GO:0050431 transforming growth factor beta binding PMID:9657149
located_inGO:0005615 extracellular space PMID:9657149
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1
UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813		 enablesGO:0005515 protein binding with PR:000028966 hTHBS1/iso:1/Clv:2 PMID:3305519
GO:0050431 transforming growth factor beta binding PMID:15342643
PR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+
UniProtKB:P35441-1, 312-1170, MOD:00693		 acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774